KEGG   ENZYME: 3.1.3.74Help
Entry
EC 3.1.3.74                 Enzyme                                 

Name
pyridoxal phosphatase;
vitamine B6 (pyridoxine) phosphatase;
PLP phosphatase;
vitamin B6-phosphate phosphatase;
PNP phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
pyridoxal-5'-phosphate phosphohydrolase
Reaction(IUBMB)
pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate [RN:R00173]
Reaction(KEGG)
R00173;
(other) R01911 R02494
Show
Substrate
pyridoxal 5'-phosphate [CPD:C00018];
H2O [CPD:C00001]
Product
pyridoxal [CPD:C00250];
phosphate [CPD:C00009]
Comment
Requires Mg2+. This enzyme is specific for phosphorylated vitamin B6 compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. This reaction can also be carried out by EC 3.1.3.1 (alkaline phosphatase) and EC 3.1.3.2 (acid phosphatase), but these enzymes have very broad substrate specificities.
History
EC 3.1.3.74 created 2004
Pathway
Vitamin B6 metabolism
Metabolic pathways
Orthology
K07758  
pyridoxal phosphatase
K13248  
pyridoxal phosphate phosphatase PHOSPHO2
Genes
HSA: 
493911(PHOSPHO2) 57026(PDXP)
PTR: 
100615101(PDXP) 459719(PHOSPHO2)
PPS: 
103786618(PDXP) 103787064(PHOSPHO2)
GGO: 
101131418(PHOSPHO2)
PON: 
103888967(PDXP) 103889977(PHOSPHO2)
NLE: 
100582371(PDXP) 100582638(PHOSPHO2)
MCC: 
100429653(PHOSPHO2) 107000658(PDXP)
MCF: 
101865359(PDXP) 102140894(PHOSPHO2)
CSAB: 
103217273(PHOSPHO2) 103223282(PDXP)
RRO: 
104655044(PHOSPHO2) 104682575(PDXP)
CJC: 
100399798(PHOSPHO2) 100399981(PDXP)
SBQ: 
101028765(PHOSPHO2) 101054290(PDXP)
MMU: 
57028(Pdxp) 73373(Phospho2)
RNO: 
295663(Phospho2) 727679(Pdxp)
CGE: 
100755599(Pdxp) 100764721(Phospho2)
NGI: 
103737980(Phospho2) 103741821 103748608(Pdxp)
HGL: 
101719475(Pdxp) 101722484(Phospho2)
TUP: 
102469858(PDXP) 102479589(PHOSPHO2)
CFA: 
100684043(PHOSPHO2) 100688635(PDXP)
AML: 
100472338(PHOSPHO2) 105235510(PDXP)
UMR: 
103659545(PHOSPHO2) 103676541(PDXP)
FCA: 
101087253(PHOSPHO2) 101093872(PDXP) 101093877(PHOSPHO2)
PTG: 
102959923(PDXP) 102967832(PHOSPHO2)
BTA: 
506308(PDXP) 507308(PHOSPHO2)
BOM: 
102272704(PHOSPHO2) 102286951(PDXP)
PHD: 
102315311 102321640(PDXP) 102330660(PHOSPHO2)
CHX: 
102170186(PHOSPHO2) 102180199(PDXP)
OAS: 
101119113(PHOSPHO2) 101123544(PDXP)
SSC: 
100152929(PHOSPHO2) 100623846(PDXP)
CFR: 
102504844(PHOSPHO2)
BACU: 
103003329(PDXP) 103007775(PHOSPHO2)
LVE: 
103073497(PDXP) 103080288(PHOSPHO2)
ECB: 
100052701(PHOSPHO2) 100630816(PDXP)
MYB: 
102251338 102251449(PHOSPHO2) 102252377(PDXP)
MYD: 
102752571(PHOSPHO2) 102773967(PDXP)
PALE: 
102877859(PHOSPHO2) 102883992(PDXP)
LAV: 
100668141(PHOSPHO2)
MDO: 
100024396(PHOSPHO2) 100025700(PDXP)
SHR: 
100922295(PHOSPHO2) 100924589(PDXP)
OAA: 
GGA: 
424160(PHOSPHO2) 771207(PDXP)
MGP: 
100539695(PDXP) 100542382(PHOSPHO2)
CJO: 
107313943(PDXP) 107316687(PHOSPHO2)
APLA: 
101794607(PHOSPHO2) 101799043(PDXP)
TGU: 
100219816(PHOSPHO2) 101234251(PDXP)
GFR: 
102033327(PDXP) 102044333(PHOSPHO2)
FAB: 
101809714(PDXP) 101815279(PHOSPHO2)
PHI: 
102108764(PDXP) 102113616(PHOSPHO2)
CCW: 
104693891(PHOSPHO2) 104696513(PDXP)
FPG: 
106112195(PDXP)
FCH: 
106631635(PDXP)
CLV: 
102095123(PHOSPHO2) 102098989(PDXP)
AAM: 
106488247(PDXP) 106499198(PHOSPHO2)
ASN: 
102376120(PDXP) 102382568(PHOSPHO2)
AMJ: 
102566322(PDXP) 102570726(PHOSPHO2)
PSS: 
102450474(PDXP) 102450695(PHOSPHO2)
CMY: 
102933406(PHOSPHO2)
ACS: 
100559885(phospho2) 100562224(pdxp)
PBI: 
103059635(PHOSPHO2)
GJA: 
107105933(PDXP) 107119693(PHOSPHO2)
XLA: 
779316(phospho2)
XTR: 
493318(phospho2)
DRE: 
561030(pdxp) 799638(phospho2)
TRU: 
101069249(phospho2) 101079776(pdxp)
TNG: 
MZE: 
101464860(pdxp) 101485115(phospho2)
OLA: 
101158449(pdxp) 101174256(phospho2)
XMA: 
SASA: 
LCM: 
102350970(PHOSPHO2) 102351909(PDXP)
CMK: 
103176439(phospho2)
BFO: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD17453(Dsim_GD17453) Dsimw501_GD24455(Dsim_GD24455)
DWI: 
DYA: 
Dyak_GE15859(dyak_GLEANR_17334) Dyak_GE17368(dyak_GLEANR_18704)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
725365(GB15231)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
TCA: 
BMOR: 
DPX: 
ISC: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0125959.1(Lj0g3v0125959.1) Lj0g3v0193989.1(Lj0g3v0193989.1) Lj0g3v0319719.1(Lj0g3v0319719.1) Lj0g3v0319729.1(Lj0g3v0319729.1) Lj0g3v0319769.1(Lj0g3v0319769.1) Lj0g3v0319789.1(Lj0g3v0319789.1) Lj0g3v0319799.1(Lj0g3v0319799.1) Lj3g3v0301740.1(Lj3g3v0301740.1) Lj3g3v0302750.1(Lj3g3v0302750.1) Lj3g3v2693540.1(Lj3g3v2693540.1) Lj3g3v2693540.2(Lj3g3v2693540.2)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0003s02940g POPTR_0008s20130g(POPTRDRAFT_657611) POPTR_0018s05070g(POPTRDRAFT_736883)
VVI: 
SLY: 
101246036 101259946(psi14C) 543790(psi14B) 544179(psi14A)
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
DOSA: 
Os02t0226200-01(Os02g0226200)
OBR: 
BDI: 
SBI: 
SORBI_03g027020(SORBIDRAFT_03g027020) SORBI_04g008010(SORBIDRAFT_04g008010)
ZMA: 
100502503(GRMZM2G021106) 103636051(GRMZM2G142776)
SITA: 
PDA: 
EGU: 
MUS: 
SMO: 
PPP: 
CRE: 
VCN: 
CCP: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112429(AGABI1DRAFT_112429)
ABV: 
AGABI2DRAFT192397(AGABI2DRAFT_192397)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MLR: 
ACAN: 
TET: 
PTM: 
SMIN: 
v1.2.000195.t1(symbB.v1.2.000195.t1)
TPS: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:1322411]
  Authors
Fonda ML.
  Title
Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes.
  Journal
J. Biol. Chem. 267 (1992) 15978-83.
Reference
2  [PMID:7625842]
  Authors
Fonda ML, Zhang YN.
  Title
Kinetic mechanism and divalent metal activation of human erythrocyte pyridoxal phosphatase.
  Journal
Arch. Biochem. Biophys. 320 (1995) 345-52.
Reference
3  [PMID:14522954]
  Authors
Jang YM, Kim DW, Kang TC, Won MH, Baek NI, Moon BJ, Choi SY, Kwon OS.
  Title
Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution.
  Journal
J. Biol. Chem. 278 (2003) 50040-6.
  Sequence
[hsa:57026] [mmu:57028]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9076-92-0

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