KEGG   ENZYME: 3.1.3.75Help
Entry
EC 3.1.3.75                 Enzyme                                 

Name
phosphoethanolamine/phosphocholine phosphatase;
PHOSPHO1;
3X11A
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
phosphoethanolamine phosphohydrolase
Reaction(IUBMB)
(1) O-phosphoethanolamine + H2O = ethanolamine + phosphate [RN:R06870];
(2) phosphocholine + H2O = choline + phosphate [RN:R06871]
Reaction(KEGG)
Substrate
O-phosphoethanolamine [CPD:C00346];
H2O [CPD:C00001];
phosphocholine [CPD:C00588]
Product
ethanolamine [CPD:C00189];
phosphate [CPD:C00009];
choline [CPD:C00114]
Comment
Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine.
History
EC 3.1.3.75 created 2004
Pathway
Glycerophospholipid metabolism
Metabolic pathways
Orthology
K06124  
phosphoethanolamine/phosphocholine phosphatase
Genes
HSA: 
162466(PHOSPHO1)
PTR: 
455200(PHOSPHO1)
PPS: 
100995130(PHOSPHO1)
GGO: 
101135403(PHOSPHO1)
PON: 
100453832(PHOSPHO1)
NLE: 
100595367(PHOSPHO1)
MCC: 
698959(PHOSPHO1)
MCF: 
102142920(PHOSPHO1)
CSAB: 
103243637(PHOSPHO1)
RRO: 
104659770(PHOSPHO1)
CJC: 
100393769(PHOSPHO1)
SBQ: 
101044528(PHOSPHO1)
MMU: 
237928(Phospho1)
RNO: 
287644(Phospho1)
CGE: 
100760987(Phospho1)
NGI: 
103738361(Phospho1)
HGL: 
101721548(Phospho1)
OCU: 
100344433(PHOSPHO1)
TUP: 
102493382(PHOSPHO1)
CFA: 
491069(PHOSPHO1)
AML: 
100484341(PHOSPHO1)
FCA: 
101095209(PHOSPHO1)
BTA: 
524639(PHOSPHO1)
BOM: 
102281872(PHOSPHO1)
PHD: 
102334987(PHOSPHO1)
CHX: 
102190731(PHOSPHO1)
OAS: 
101112333(PHOSPHO1)
SSC: 
100621753(PHOSPHO1)
CFR: 
102520575(PHOSPHO1)
BACU: 
103013714(PHOSPHO1)
LVE: 
103077302(PHOSPHO1)
ECB: 
100055957(PHOSPHO1)
MYB: 
MYD: 
102775093(PHOSPHO1)
PALE: 
102882188(PHOSPHO1)
LAV: 
100674633(PHOSPHO1)
MDO: 
100021539(PHOSPHO1)
OAA: 
100087239(PHOSPHO1)
GGA: 
395650(PHOSPHO1)
MGP: 
100547041(PHOSPHO1)
CJO: 
107325092(PHOSPHO1)
APLA: 
101795093(PHOSPHO1)
FAB: 
101808298(PHOSPHO1)
PHI: 
102101486(PHOSPHO1)
FPG: 
101914984(PHOSPHO1)
FCH: 
102056152(PHOSPHO1)
CLV: 
102086540(PHOSPHO1)
AAM: 
106495963(PHOSPHO1)
ASN: 
102371816(PHOSPHO1)
AMJ: 
102576418(PHOSPHO1)
PSS: 
102447415(PHOSPHO1)
CMY: 
102936439(PHOSPHO1)
ACS: 
100563935(phospho1)
PBI: 
103055208(PHOSPHO1)
GJA: 
107108721(PHOSPHO1)
XTR: 
100492656(phospho1)
DRE: 
100002812(phospho1)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102365260(PHOSPHO1)
CMK: 
103183818(phospho1)
OSA: 
4324704(P0690B02.6)
DOSA: 
Os01t0720400-01(Os01g0720400)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_03g033100(SORBIDRAFT_03g033100)
ZMA: 
100191227(GRMZM5G836174) 100281893(TIDP3606) 100284789(pco107612)
SITA: 
 » show all
Taxonomy
Reference
1  [PMID:9990301]
  Authors
Houston B, Seawright E, Jefferies D, Hoogland E, Lester D, Whitehead C, Farquharson C.
  Title
Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes.
  Journal
Biochim. Biophys. Acta. 1448 (1999) 500-6.
  Sequence
[gga:395650]
Reference
2  [PMID:14983068]
  Authors
Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C.
  Title
Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.
  Journal
Protein. Eng. 16 (2003) 889-95.
  Sequence
[hsa:162466]
Reference
3  [PMID:15175005]
  Authors
Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C.
  Title
Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.
  Journal
Biochem. J. 382 (2004) 59-65.
  Sequence
[hsa:162466]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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