KEGG   ENZYME: 3.1.3.78Help
Entry
EC 3.1.3.78                 Enzyme                                 

Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
IpgD;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Comment
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
History
EC 3.1.3.78 created 2008
Orthology
K13084  
phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  
phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
HSA: 
55529(TMEM55A) 90809(TMEM55B)
PTR: 
464281(TMEM55A) 465201(TMEM55B)
PPS: 
100968374(TMEM55A) 100988983(TMEM55B)
GGO: 
101129459(TMEM55A) 101132752(TMEM55B)
PON: 
100451858(TMEM55A) 100454477(TMEM55B)
NLE: 
100587627(TMEM55A) 100593745(TMEM55B)
MCC: 
100428001(TMEM55B) 696779(TMEM55A)
MCF: 
101866619(TMEM55B) 102115056(TMEM55A)
CSAB: 
RRO: 
104654642(TMEM55A) 104673120(TMEM55B)
CJC: 
100402264(TMEM55B) 100407390(TMEM55A)
SBQ: 
101027468(TMEM55B) 101033445(TMEM55A)
MMU: 
219024(Tmem55b) 72519(Tmem55a)
RNO: 
362490(Tmem55a) 364298(Tmem55b)
CGE: 
100757444(Tmem55b) 100767770(Tmem55a)
NGI: 
103729539(Tmem55a) 103733665(Tmem55b)
HGL: 
101709122(Tmem55b) 101718072(Tmem55a)
OCU: 
100349176(TMEM55B) 100353159(TMEM55A)
TUP: 
102475472(TMEM55B) 102487160 102499548(TMEM55A)
CFA: 
477939(TMEM55A) 482559(TMEM55B)
AML: 
100479476(TMEM55A) 100484149(TMEM55B)
UMR: 
103656314(TMEM55B) 103661475(TMEM55A)
FCA: 
101080798(TMEM55B) 101088301(TMEM55A)
PTG: 
102952164(TMEM55A) 102956222(TMEM55B)
BTA: 
615077(TMEM55B) 616641(TMEM55A)
BOM: 
102268358(TMEM55B) 102277826(TMEM55A)
PHD: 
102333254(TMEM55A) 102337300(TMEM55B)
CHX: 
102172557(TMEM55A) 102177240(TMEM55B)
OAS: 
101111559(TMEM55A) 101117510(TMEM55B)
SSC: 
100155939(TMEM55B) 100156639(TMEM55A)
CFR: 
102505095(TMEM55A) 102507379(TMEM55B)
BACU: 
103007264(TMEM55A) 103012880(TMEM55B)
LVE: 
103084248(TMEM55B) 103085248(TMEM55A)
ECB: 
100050790(TMEM55A) 100058648(TMEM55B)
MYB: 
102241548(TMEM55A) 102252193(TMEM55B)
MYD: 
102754867(TMEM55B) 102773968(TMEM55A)
PALE: 
102898229(TMEM55A) 102898278(TMEM55B)
LAV: 
100660816(TMEM55B) 100664641(TMEM55A)
MDO: 
100022045(TMEM55A) 100022893(TMEM55B)
SHR: 
100916303(TMEM55A) 100924788(TMEM55B)
OAA: 
100086066(TMEM55B) 100092908(TMEM55A)
GGA: 
420221(TMEM55A)
MGP: 
100542892(TMEM55A)
CJO: 
107307004(TMEM55B) 107310378(TMEM55A)
APLA: 
101802244(TMEM55A)
TGU: 
100226950(TMEM55A)
GFR: 
102040381(TMEM55A)
FAB: 
101810791(TMEM55A)
PHI: 
102099741(TMEM55A) 102101128(TMEM55B)
CCW: 
104692756(TMEM55A)
FPG: 
101922579(TMEM55A)
FCH: 
102055459(TMEM55A)
CLV: 
102090519(TMEM55A)
AAM: 
106496195(TMEM55A)
ASN: 
102373932(TMEM55A) 102374449(TMEM55B)
AMJ: 
102562249(TMEM55B) 102570595(TMEM55A)
PSS: 
CMY: 
ACS: 
100556773(tmem55a) 100567084(tmem55b)
PBI: 
103047975(TMEM55B) 103054248(TMEM55A)
GJA: 
107105993(TMEM55A) 107116165(TMEM55B)
XLA: 
494834(tmem55b) 734343(tmem55a)
XTR: 
100170610(tmem55b) 448483(tmem55a)
DRE: 
556136(tmem55ba) 566642(tmem55a)
TRU: 
101062738 101068075(tmem55a) 101075194(tmem55b)
TNG: 
MZE: 
101466447 101468284(tmem55a) 101479252(tmem55b)
OLA: 
XMA: 
102224770 102227240(tmem55a) 102234414(tmem55b)
SASA: 
LCM: 
102348811(TMEM55A) 102357306(TMEM55B)
CMK: 
103191060(tmem55a)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD12881(Dsim_GD12881)
DWI: 
DYA: 
Dyak_GE20289(dyak_GLEANR_4131)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_Y71H2AM.2(Y71H2AM.2)
CBR: 
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
AQU: 
STY: 
STY1121(sigD)
STT: 
t1828(sigD)
SEX: 
SENT: 
STM: 
STM1091(sopB)
SEO: 
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
SENR: 
SEND: 
SENI: 
SEEN: 
SPT: 
SPA1759(sigD)
SEK: 
SPQ: 
SEI: 
SPC_2659(sigD)
SEC: 
SCH_1043(sopB)
SEH: 
SHB: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SEG: 
SG0980(sopB)
SEL: 
SPUL_1966(sopB)
SEGA: 
SET: 
SEN0955(sopB)
SENA: 
SENO: 
SENV: 
SENQ: 
SENL: 
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
SENE: 
IA1_05370(sopB)
SENC: 
SES: 
SBG: 
SBG_0939(sopB)
SBZ: 
SBV: 
YAL: 
AT01_2850(sopB)
SFL: 
CP0133(ipgD)
SFE: 
SFxv_4976(ipgD)
SSN: 
SSON_P095(ipgD)
SBC: 
SDY: 
SDY_P171(ipgD)
SDZ: 
PAY: 
SGL: 
SOD: 
Sant_3206(sigD) Sant_3209(sigD2)
PSI: 
PSX: 
DR96_586(sopB)
VAN: 
LAG: 
VAU: 
PPK: 
PPNO: 
PPNM: 
CDN: 
HMC: 
PSF: 
PSE_2750(ipgD)
PNL: 
PNK_0614(ipgD)
 » show all
Taxonomy
Reference
1  [PMID:12356723]
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO. J. 21 (2002) 5069-78.
  Sequence
[sfl:CP0133]
Reference
2  [PMID:16365287]
  Authors
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
  Title
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 18854-9.
  Sequence
[hsa:55529 90809]
Reference
3  [PMID:17940011]
  Authors
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
  Title
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 16834-9.
Reference
4  [PMID:17389247]
  Authors
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
  Title
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
  Journal
J. Gen. Physiol. 129 (2007) 267-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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