KEGG   ENZYME: 3.1.3.80Help
Entry
EC 3.1.3.80                 Enzyme                                 

Name
2,3-bisphosphoglycerate 3-phosphatase;
MIPP1;
2,3-BPG 3-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
2,3-bisphospho-D-glycerate 3-phosphohydrolase
Reaction(IUBMB)
2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate [RN:R09532]
Reaction(KEGG)
Substrate
2,3-bisphospho-D-glycerate [CPD:C01159];
H2O [CPD:C00001]
Product
2-phospho-D-glycerate [CPD:C00631];
phosphate [CPD:C00009]
Comment
This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 3.1.3.13/EC 5.4.2.12 [bisphosphoglycerate phosphatase/phosphoglycerate mutase (2,3-diphosphoglycerate-independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase).
History
EC 3.1.3.80 created 2010
Pathway
Glycolysis / Gluconeogenesis
Metabolic pathways
Orthology
K03103  
multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
Genes
HSA: 
9562(MINPP1)
PTR: 
450579(MINPP1)
PPS: 
100980933(MINPP1)
GGO: 
101144263(MINPP1)
PON: 
100173135(MINPP1)
NLE: 
100602225(MINPP1)
MCC: 
704362(MINPP1)
MCF: 
CJC: 
100391750(MINPP1)
MMU: 
17330(Minpp1)
RNO: 
29688(Minpp1)
CGE: 
100766430(Minpp1)
NGI: 
103738050(Minpp1)
HGL: 
101711589(Minpp1)
OCU: 
100358192(MINPP1)
TUP: 
102484201(MINPP1)
CFA: 
486462(MINPP1)
AML: 
UMR: 
103661917(MINPP1)
FCA: 
101091150(MINPP1)
PTG: 
102971475(MINPP1)
BTA: 
541067(MINPP1)
BOM: 
102266889(MINPP1)
PHD: 
102338873(MINPP1)
CHX: 
102187288(MINPP1)
OAS: 
101118833(MINPP1)
SSC: 
100152243(MINPP1)
CFR: 
BACU: 
103015775(MINPP1)
LVE: 
103073572(MINPP1)
ECB: 
100062448(MINPP1)
MYB: 
102256717(MINPP1)
MYD: 
102754386(MINPP1)
PALE: 
102882782(MINPP1)
MDO: 
100022488(MINPP1)
SHR: 
OAA: 
GGA: 
395356(MINPP1)
MGP: 
APLA: 
101798501(MINPP1)
TGU: 
100225117(MINPP1)
FAB: 
101807959(MINPP1)
PHI: 
102106327(MINPP1)
FPG: 
101912524(MINPP1)
FCH: 
102050541(MINPP1)
CLV: 
102099022(MINPP1)
ASN: 
AMJ: 
102561123(MINPP1)
PSS: 
102458605(MINPP1)
CMY: 
102941827(MINPP1)
ACS: 
100555619(minpp1)
PBI: 
103064022(MINPP1)
XTR: 
100493648(minpp1)
DRE: 
394075(minpp1b) 561891(minpp1a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103180855(minpp1)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
100577002 725931(GB17098)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0008s07260g(POPTRDRAFT_765615) POPTR_0010s19200g(POPTRDRAFT_833751)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0818100-01(Os03g0818100)
OBR: 
BDI: 
SBI: 
SORBI_01g003490(SORBIDRAFT_01g003490)
ZMA: 
100282868(pco091084)
SITA: 
PDA: 
ATR: 
s00007p00031450(AMTR_s00007p00031450) s00119p00138850(AMTR_s00119p00138850)
SMO: 
PPP: 
CRE: 
VCN: 
CCP: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_059910(101.t00003)
EDI: 
ACAN: 
PIF: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:18413611]
  Authors
Cho J, King JS, Qian X, Harwood AJ, Shears SB
  Title
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 5998-6003.
  Sequence
[ddi:DDB_G0285339] [hsa:9562]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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