KEGG   ENZYME: 3.1.3.80Help
Entry
EC 3.1.3.80                 Enzyme                                 
Name
2,3-bisphosphoglycerate 3-phosphatase;
MIPP1;
2,3-BPG 3-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
2,3-bisphospho-D-glycerate 3-phosphohydrolase
Reaction(IUBMB)
2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate [RN:R09532]
Reaction(KEGG)
Substrate
2,3-bisphospho-D-glycerate [CPD:C01159];
H2O [CPD:C00001]
Product
2-phospho-D-glycerate [CPD:C00631];
phosphate [CPD:C00009]
Comment
This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 3.1.3.13/EC 5.4.2.1 (bisphosphoglycerate phosphatase/phosphoglycerate mutase) and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase).
Reference
1  [PMID:18413611]
  Authors
Cho J, King JS, Qian X, Harwood AJ, Shears SB
  Title
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 5998-6003.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system