KEGG   ENZYME: 3.1.3.85Help
Entry
EC 3.1.3.85                 Enzyme                                 

Name
glucosyl-3-phosphoglycerate phosphatase;
GpgP protein
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
alpha-D-glucosyl-3-phospho-D-glycerate phosphohydrolase
Reaction(IUBMB)
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate [RN:R09664]
Reaction(KEGG)
Substrate
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate [CPD:C19791];
H2O [CPD:C00001]
Product
2-O-(alpha-D-glucopyranosyl)-D-glycerate [CPD:C19792];
phosphate [CPD:C00009]
Comment
The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg2+, Mn2+ or Co2+) stimulate activity [1,2].
History
EC 3.1.3.85 created 2011
Orthology
K22306  glucosyl-3-phosphoglycerate phosphatase
Genes
SRR: SerAS9_4157
SRY: M621_20990
SRS: SerAS12_4158
SRA: SerAS13_4158
HSO: HS_1664(gpm)
HSM: HSM_1826
AAT: D11S_0705
AAN: D7S_00967
AAH: CF65_00942
AACN: AANUM_0700
BCEO: I35_0744
SMER: DU99_19350
EAD: OV14_a1248(gpmB)
RSU: NHU_01105
MTU: Rv2419c(gpgP)
MTC: MT2492
MRA: MRA_2445
MTUR: CFBS_2563
MTD: UDA_2419c
MTUE: J114_12960
MTUH: I917_17075
MTUL: TBHG_02358
MTUT: HKBT1_2554
MTUU: HKBT2_2557
MBO: BQ2027_MB2442C(gpgp)
MBB: BCG_2435c
MBT: JTY_2429
MBX: BCGT_2249
MAF: MAF_24340
MMIC: RN08_2682
MLE: ML1452
MLB: MLBr01452
MPA: MAP_2242c
MAO: MAP4_1582
MAVI: RC58_07880
MAVU: RE97_07880
MAV: MAV_1752
MAVD: NF84_07830
MAVR: LA63_07965
MAVA: LA64_07985
MIT: OCO_18090
MIA: OCU_18270
MID: MIP_02552
MIR: OCQ_15700
MUL: MUL_3691(gpm_1)
MMC: Mmcs_3528
MKM: Mkms_3601
MJL: Mjls_3533
MMI: MMAR_3747(gpm_1)
MMAE: MMARE11_36540(gpm_1)
MMM: W7S_07700
MLI: MULP_03999(gpm_1)
MHAD: B586_09010
MVA: Mvan_3924
MGI: Mflv_2655
MPHL: MPHLCCUG_03565(gpgP)
MVQ: MYVA_3755
MAB: MAB_1623
MABB: MASS_1717
MABO: NF82_08215
MCHE: BB28_08840
MSTE: MSTE_01623
MJD: JDM601_1489(gpm_1)
ASD: AS9A_1140
CGL: NCgl2268(Cgl2350)
CGB: cg2581
CGU: WA5_2268
CGT: cgR_2233
CGM: cgp_2581
CGJ: AR0_11255
CEF: CE2254
CDI: DIP1773
CDP: CD241_1705(gpmB)
CDH: CDB402_1661(gpmB)
CDT: CDHC01_1707(gpmB)
CDE: CDHC02_1691(gpmB)
CDR: CDHC03_1672(gpmB)
CDA: CDHC04_1666(gpmB)
CDZ: CD31A_1776(gpmB)
CDB: CDBH8_1745(gpmB)
CDS: CDC7B_1755(gpmB)
CDD: CDCE8392_1669(gpmB)
CDW: CDPW8_1766(gpmB)
CDV: CDVA01_1632(gpmB)
CDIP: ERS451417_01789(gpmB)
CJK: jk0569(gpmB)
CUR: cu1361
CUA: CU7111_1341(gpmB)
CKP: ckrop_1352(gpmB)
CPU: cpfrc_01582(gpmB)
CPL: Cp3995_1616(gpmB)
CPG: Cp316_1614(gpmB)
CPP: CpP54B96_1603(gpmB)
CPK: Cp1002_1575(gpmB)
CPQ: CpC231_1577(gpmB)
CPX: CpI19_1582(gpmB2)
COR: Cp267_1639(gpmB)
COP: Cp31_1573(gpmB2)
COD: Cp106_1537(gpmB)
COS: Cp4202_1566(gpmB)
COI: CpCIP5297_1587(gpmB2)
COE: Cp258_1579(gpmB)
COU: Cp162_1553(gpmB2)
CPSE: CPTA_02170
CPSU: CPTB_01586
CPSF: CPTC_02170
CRD: CRES_0649(gpmB)
CUL: CULC22_01734(gpmB)
CUC: CULC809_01657(gpmB)
CUE: CULC0102_1792(gpmB)
CUN: Cul210932_1752(gpmB2)
CUS: CulFRC11_1652(gpmB2)
CUQ: Cul210931_1650(gpmB2)
CUZ: Cul05146_1736(gpmB2)
CUJ: CUL131002_1674c(gpmB2)
CVA: CVAR_0931(gpmB)
CTER: A606_03640
CGY: CGLY_11385(gpmB)
COA: DR71_1727
CSX: CSING_10300(gpgP)
CKU: UL82_03520(gpgP)
CCJ: UL81_08740(gpmB)
CMV: CMUST_12040(gpmB)
CEI: CEPID_09620(gpmB)
CTED: CTEST_09850(gpgP)
CUT: CUTER_08180(gpmB)
CSP: WM42_2089
CPHO: CPHO_03335
CGV: CGLAU_09640(gpgP)
CAQU: CAQU_09300
CAMG: CAMM_03955
NFA: NFA_13780
NCY: NOCYR_1448(gpmB)
RER: RER_37740
REY: O5Y_17415
ROP: ROP_10170
REQ: REQ_29650
RHB: NY08_439
RFA: A3L23_03762(gpgP)
RHS: A3Q41_04478(gpgP)
RHU: A3Q40_01033(gpgP_2)
GBR: Gbro_3192
GPO: GPOL_c29680(gmpB)
GOR: KTR9_3226
TPR: Tpau_2806
SRT: Srot_1008
SCO: SCO2576(pgm2)
SMA: SAVERM_5481(gpmA2)
SGR: SGR_4971
SGB: WQO_10655
SCT: SCAT_1620
SFA: Sfla_4310
SBH: SBI_07140(gpm3)
SHY: SHJG_4071
SVE: SVEN_2358
SALB: XNR_4361
SALS: SLNWT_5301
STRP: F750_2399
SFI: SFUL_2138
SALU: DC74_3105
SALL: SAZ_16575
STRE: GZL_05826
SLD: T261_5488
STRM: M444_12595
SAMB: SAM23877_2626(gpgP)
SPRI: SPRI_4947
SRW: TUE45_03181(gpgP)
SLE: sle_46590(sle_46590)
STRD: NI25_26160
SMAL: SMALA_2586
SLAU: SLA_2247
SALF: SMD44_02866(gpmB)
SALJ: SMD11_4558(gpmB)
SLX: SLAV_24675(gpgP)
KSK: KSE_25920
ARM: ART_1031
BCV: Bcav_1638
JDE: Jden_1640
LMOI: VV02_12580
XCE: Xcel_2249
IDO: I598_0164(gpgP)
CFL: Cfla_2273
CFI: Celf_2408
SERJ: SGUI_0045
BLIN: BLSMQ_1817
PAC: PPA0838
PACC: PAC1_04480
PACH: PAGK_1297
CACN: RN83_04730
PFR: PFREUD_08550(gmpB) PFREUD_11950(pgm2) PFREUD_12180(pgm)
MPH: MLP_35980
NCA: Noca_1822
NDK: I601_3863(gpgP)
KFL: Kfla_2335
TFU: Tfu_2169
NDA: Ndas_3358
NAL: B005_0454
TCU: Tcur_1556
SRO: Sros_7259
FAL: FRAAL1939(gpm)
NML: Namu_1510
GOB: Gobs_1608
BSD: BLASA_1566(gpm)
MMAR: MODMU_1736(gpm)
KRA: Krad_3448
SEN: SACE_1433
AMD: AMED_6693(gpm)
AMN: RAM_34335
AMM: AMES_6594(gpm)
AMZ: B737_6594(gpm)
AOI: AORI_2014(gpm)
AJA: AJAP_29460(gpgP)
AMQ: AMETH_1785(gpm)
PDX: Psed_2006
PSEA: WY02_25465
PSEE: FRP1_05965
PSEH: XF36_16890
AMI: Amir_1199
SESP: BN6_14350
KAL: KALB_1627
ACTI: UA75_08240
ACAD: UA74_08260
AHG: AHOG_07745(gpgP)
ALL: CRK55493
SAQ: Sare_3852
MIL: ML5_3427
ASE: ACPL_1385
ACTN: L083_1532
AFS: AFR_07730
ACTS: ACWT_1264
CAI: Caci_7256
SNA: Snas_5474
AHE: Arch_1063
TPYO: X956_04545
BLO: BL0966
BLJ: BLD_0720
BLN: Blon_1729
BLON: BLIJ_1790
BLF: BLIF_0666
BLL: BLJ_0759
BLM: BLLJ_0645
BLG: BIL_11970
BAD: BAD_0869
BADL: BADO_0924
BLA: BLA_1271
BBB: BIF_01798
BBC: BLC1_0715
BLV: BalV_0722
BLW: W7Y_0749
BLS: W91_0771
BANI: Bl12_0699
BANL: BLAC_03820
BANM: EN10_03785
BDE: BDP_1229
BDN: BBDE_1174
BBI: BBIF_1062(gpm4)
BBP: BBPR_1123
BBF: BBB_1050(gpmB)
BBRU: Bbr_0779
BBRE: B12L_0718
BBRV: B689b_0811
BBRJ: B7017_0752
BBRC: B7019_0762
BBRN: B2258_0750
BBRS: BS27_0789
BBRD: BBBR_0747
BAST: BAST_0694
BTP: D805_1732
BCOR: BCOR_0594
BKS: BBKW_0919
BPSP: AH67_04065
BANG: BBAG_0970
BCAT: BBCT_0891
BPSC: BBPC_0890
BSCA: BBSC_1109
GVG: HMPREF0421_20973(gpm)
SIJ: SCIP_0947
PDO: PSDT_0529
TBI: Tbis_2451
DGO: DGo_CA2066(gpmB)
 » show all
Taxonomy
Reference
1  [PMID:17189358]
  Authors
Costa J, Empadinhas N, da Costa MS
  Title
Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina.
  Journal
J. Bacteriol. 189 (2007) 1648-54.
  Sequence
Reference
2  [PMID:16428406]
  Authors
Costa J, Empadinhas N, Goncalves L, Lamosa P, Santos H, da Costa MS
  Title
Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.
  Journal
J. Bacteriol. 188 (2006) 1022-30.
  Sequence
[mbu:Mbur_0736]
Reference
3  [PMID:22355692]
  Authors
Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N
  Title
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis.
  Journal
Sci. Rep. 1 (2011) 177.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.85
IUBMB Enzyme Nomenclature: 3.1.3.85
ExPASy - ENZYME nomenclature database: 3.1.3.85
BRENDA, the Enzyme Database: 3.1.3.85

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