KEGG   ENZYME: 3.1.3.86Help
Entry
EC 3.1.3.86                 Enzyme                                 

Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase;
SHIP1;
SHIP2;
SHIP;
p150Ship
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate [RN:R09827]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [CPD:C05981];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [CPD:C11554];
phosphate [CPD:C00009]
Comment
This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
History
EC 3.1.3.86 created 2011
Pathway
Inositol phosphate metabolism
Orthology
K03084  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
K15909  
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Genes
HSA: 
3635(INPP5D) 3636(INPPL1)
PTR: 
451403(INPPL1) 470683(INPP5D)
PPS: 
100988546(INPP5D) 100992766(INPPL1)
GGO: 
PON: 
MCC: 
717832 718421(INPPL1)
MCF: 
102115401(INPPL1) 102134197(INPP5D)
MMU: 
16331(Inpp5d) 16332(Inppl1)
RNO: 
54259(Inpp5d) 65038(Inppl1)
CGE: 
100764735(Inpp5d) 100772102(Inppl1)
HGL: 
101698814(Inppl1) 101711777(Inpp5d)
TUP: 
102485077(INPPL1) 102487042(INPP5D)
CFA: 
100688270(INPP5D) 485209(INPPL1)
AML: 
100464150(INPP5D) 100482460(INPPL1)
FCA: 
101095611(INPPL1) 101100500(INPP5D)
PTG: 
102956183(INPPL1) 102971986(INPP5D)
BTA: 
507329(INPP5D) 783833(INPPL1)
BOM: 
102266365(INPP5D) 102278222(INPPL1)
PHD: 
102315017(INPP5D) 102326290(INPPL1)
CHX: 
102170935(INPP5D) 102178924(INPPL1)
OAS: 
101112941(INPP5D) 101121707(INPPL1)
SSC: 
100462718(INPPL1) 100526019(INPP5D)
CFR: 
102506956(INPP5D) 102509164(INPPL1)
BACU: 
102999607(INPPL1) 103008465(INPP5D)
LVE: 
103078405(INPPL1) 103091136(INPP5D)
ECB: 
100064896(INPP5D) 100066037(INPPL1)
MYB: 
102240810(INPP5D) 102248134(INPPL1)
MYD: 
102755641(INPPL1) 102769498(INPP5D)
PALE: 
102882532(INPP5D) 102890098(INPPL1)
MDO: 
100015500(INPPL1) 100021361(INPP5D)
SHR: 
100916136(INPP5D) 100930081(INPPL1)
OAA: 
GGA: 
424745(INPP5D) 428692(INPPL1)
MGP: 
APLA: 
101797866(INPP5D)
TGU: 
FAB: 
101807549(INPPL1) 101809542(INPP5D) 101820739
PHI: 
102101537 102102439(INPPL1) 102105757(INPP5D)
FPG: 
FCH: 
CLV: 
ASN: 
102375443 102380530(INPP5D) 102388319(INPPL1)
AMJ: 
102563685(INPPL1) 102572303(INPP5D) 102576763
PSS: 
102448035(INPPL1) 102448772 102462454(INPP5D)
CMY: 
102929300 102929354(INPPL1) 102935566(INPP5D)
ACS: 
100556812(inppl1) 100561031(inpp5d)
PBI: 
103050036(INPP5D) 103051579(INPPL1) 103055569
XLA: 
399051(inpp5d)
XTR: 
100485745(inppl1) 100497417(inpp5d)
DRE: 
325179(inppl1a) 559103(inpp5d)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351582 102361839(INPPL1) 102365596(INPP5D)
CMK: 
SPU: 
HMG: 
AQU: 
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:8654924]
  Authors
Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR
  Title
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
  Journal
Genes. Dev. 10 (1996) 1084-95.
  Sequence
[mmu:16331]
Reference
2  [PMID:8643691]
  Authors
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G
  Title
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 1689-93.
  Sequence
[mmu:16331]
Reference
3  [PMID:9341117]
  Authors
Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H
  Title
Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
  Journal
J. Biol. Chem. 272 (1997) 26857-63.
Reference
4  [PMID:8769125]
  Authors
Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C
  Title
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem. Biophys. Res. Commun. 225 (1996) 243-9.
  Sequence
[hsa:3635]
Reference
5  [PMID:9824312]
  Authors
Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C
  Title
The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.
  Journal
FEBS. Lett. 437 (1998) 301-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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