KEGG   ENZYME: 3.1.3.88Help
Entry
EC 3.1.3.88                 Enzyme                                 

Name
5''-phosphoribostamycin phosphatase;
btrP (gene name);
neoI (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
5''-phosphoribostamycin phosphohydrolase
Reaction(IUBMB)
5''-phosphoribostamycin + H2O = ribostamycin + phosphate [RN:R08899]
Reaction(KEGG)
Substrate
5''-phosphoribostamycin [CPD:C18004];
H2O [CPD:C00001]
Product
ribostamycin [CPD:C01759];
phosphate [CPD:C00009]
Comment
Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity.
History
EC 3.1.3.88 created 2012
Pathway
Neomycin, kanamycin and gentamicin biosynthesis
Biosynthesis of antibiotics
Orthology
K13555  
5''-phosphoribostamycin phosphatase
Reference
1  [PMID:17482823]
  Authors
Kudo F, Fujii T, Kinoshita S, Eguchi T.
  Title
Unique O-ribosylation in the biosynthesis of butirosin.
  Journal
Bioorg. Med. Chem. 15 (2007) 4360-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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