| Entry |
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| Name |
[acyl-carrier-protein] phosphodiesterase;
ACP hydrolyase;
ACP phosphodiesterase;
AcpH;
[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase;
holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
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| Sysname |
holo-[acyl-carrier protein] 4'-pantetheine-phosphohydrolase
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| Reaction(IUBMB) |
holo-[acyl-carrier protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier protein] [RN: R01623]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
4'-phosphopantetheine [CPD: C01134];
apo-[acyl-carrier protein]
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| Comment |
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase.
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| Pathway |
| Pantothenate and CoA biosynthesis |
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| Orthology |
| acyl carrier protein phosphodiesterase |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | PAY: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | EBF: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | PPR: | | GAG: | | PIN: | | MMW: | | SFC: | | LEP: | |
» show all
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| Reference |
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| Authors |
Sobhy C. |
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| Title |
Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver. |
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| Journal |
J. Biol. Chem. 254 (1979) 8561-6. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Vagelos PR, Larrabes AR. |
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| Title |
Acyl carrier protein. IX. Acyl carrier protein hydrolase. |
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| Journal |
J. Biol. Chem. 242 (1967) 1776-81. |
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| Organism |
Escherichia coli [GN: eco], Clostridium bufyricum |
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| Reference |
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| Authors |
Thomas J, Cronan JE. |
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| Title |
The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. |
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| Journal |
J. Biol. Chem. 280 (2005) 34675-83. |
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| Organism |
Escherichia coli [GN: eco] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37288-21-4 |
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