KEGG   ENZYME: 3.1.4.37Help
Entry
EC 3.1.4.37                 Enzyme                                 

Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase;
cyclic-CMP phosphodiesterase;
2',3'-cyclic AMP phosphodiesterase;
cyclic 2',3'-nucleotide 3'-phosphodiesterase;
cyclic 2',3'-nucleotide phosphodiesterase;
2',3'-cyclic nucleoside monophosphate phosphodiesterase;
2',3'-cyclic nucleotide 3'-phosphohydrolase;
CNPase;
2',3'-cyclic nucleotide phosphohydrolase;
2':3'-cyclic nucleotide 3'-phosphodiesterase;
2':3'-CNMP-3'-ase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
Reaction(IUBMB)
nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN:R03422]
Reaction(KEGG)
Substrate
nucleoside 2',3'-cyclic phosphate [CPD:C01240];
H2O [CPD:C00001]
Product
nucleoside 2'-phosphate [CPD:C03418]
Comment
The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
History
EC 3.1.4.37 created 1976
Orthology
K01121  
2',3'-cyclic-nucleotide 3'-phosphodiesterase
K15435  
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Genes
HSA: 
1267(CNP)
PTR: 
454673(CNP)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
641337(CNP)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
12799(Cnp)
RNO: 
25275(Cnp)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
607694(CNP)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
280752(CNP)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
CDK: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
GGA: 
395921(CNP)
MGP: 
CJO: 
APLA: 
ACYG: 
TGU: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
325896(cnp)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
SPU: 
SKO: 
DPX: 
ISC: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
OVI: 
ADF: 
SCE: 
YGR247W(CPD1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E03850(NCAS0E03850)
NDI: 
NDAI_0B00960(NDAI0B00960)
TPF: 
TPHA_0A05230(TPHA0A05230)
TBL: 
TBLA_0B08020(TBLA0B08020)
TDL: 
TDEL_0G01030(TDEL0G01030)
KAF: 
KAFR_0B04390(KAFR0B04390)
DHA: 
PIC: 
PGU: 
SPAA: 
CAL: 
CAALFM_CR06690CA(CaO19.703)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NTE: 
NEUTE1DRAFT124587(NEUTE1DRAFT_124587)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
ELA: 
PFY: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
ADL: 
FME: 
GTR: 
MRR: 
CCI: 
ABP: 
AGABI1DRAFT68346(AGABI1DRAFT_68346)
ABV: 
AGABI2DRAFT199219(AGABI2DRAFT_199219)
SLA: 
PGR: 
FNU: 
 » show all
Taxonomy
Reference
1
  Authors
Drummond, G.I., Iyer, N.T. and Keith, J.
  Title
Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain.
  Journal
J. Biol. Chem. 237 (1962) 3535-3539.
Reference
2  [PMID:6274851]
  Authors
Helfman DM, Kuo JF.
  Title
A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
  Journal
J. Biol. Chem. 257 (1982) 1044-7.
Reference
3  [PMID:6263914]
  Authors
Helfman DM, Shoji M, Kuo JF.
  Title
Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
  Journal
J. Biol. Chem. 256 (1981) 6327-34.
Reference
4  [PMID:6272743]
  Authors
Kurihara T, Nishizawa Y, Takahashi Y, Odani S.
  Title
Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.
  Journal
Biochem. J. 195 (1981) 153-7.
Reference
5  [PMID:6258586]
  Authors
Nishizawa Y, Kurihara T, Takahashi Y.
  Title
Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase.
  Journal
Biochem. J. 191 (1980) 71-82.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
60098-35-3

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