KEGG   ENZYME: 3.1.4.53Help
Entry
EC 3.1.4.53                 Enzyme                                 

Name
3',5'-cyclic-AMP phosphodiesterase;
cAMP-specific phosphodiesterase;
cAMP-specific PDE;
PDE1;
PDE2A;
PDE2B;
PDE4;
PDE7;
PDE8;
PDEB1;
PDEB2
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
3',5'-cyclic-AMP 5'-nucleotidohydrolase
Reaction(IUBMB)
adenosine 3',5'-cyclic phosphate + H2O = AMP [RN:R00191]
Reaction(KEGG)
Substrate
adenosine 3',5'-cyclic phosphate [CPD:C00575];
H2O [CPD:C00001]
Product
AMP [CPD:C00020]
Comment
Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3].
History
EC 3.1.4.53 created 2008, modified 2011
Pathway
Purine metabolism
Orthology
K13293  
cAMP-specific phosphodiesterase
K13294  
cAMP-specific phosphodiesterase
Genes
DDI: 
DPP: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
Taxonomy
Reference
1  [PMID:16225937]
  Authors
Alonso GD, Schoijet AC, Torres HN, Flawia MM.
  Title
TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi.
  Journal
Mol. Biochem. Parasitol. 145 (2006) 40-9.
  Organism
Trypanosoma cruzi [GN:tcr]
  Sequence
[ncbi-gi:62999031]
Reference
2  [PMID:16644729]
  Authors
Bader S, Kortholt A, Snippe H, Van Haastert PJ.
  Title
DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells.
  Journal
J. Biol. Chem. 281 (2006) 20018-26.
  Organism
Dictyostelium discoideum [GN:ddi]
  Sequence
Reference
3  [PMID:11930017]
  Authors
Rascon A, Soderling SH, Schaefer JB, Beavo JA.
  Title
Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 4714-9.
  Organism
Trypanosoma brucei [GN:tbr]
  Sequence
[ncbi-gi:12003122]
Reference
4  [PMID:16522215]
  Authors
Johner A, Kunz S, Linder M, Shakur Y, Seebeck T.
  Title
Cyclic nucleotide specific phosphodiesterases of Leishmania major.
  Journal
BMC. Microbiol. 6 (2006) 25.
  Organism
Leishmania major [GN:lma]
  Sequence
[ncbi-gi:40646534 40646532]
Reference
5  [PMID:10564757]
  Authors
Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E.
  Title
Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei.
  Journal
Biochim. Biophys. Acta. 1472 (1999) 431-46.
Reference
6  [PMID:8810311]
  Authors
Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H
  Title
Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli.
  Journal
J. Biol. Chem. 271 (1996) 25423-9.
  Organism
Escherichia coli [GN:eco]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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