KEGG   ENZYME: 3.1.4.56Help
Entry
EC 3.1.4.56                 Enzyme                                 

Name
7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase;
MptB
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
7,8-dihydroneopterin 2',3'-cyclic phosphate 2'/3'-phosphodiesterase
Reaction(IUBMB)
(1) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate [RN:R10344];
(2) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate [RN:R10345]
Reaction(KEGG)
Substrate
7,8-dihydroneopterin 2',3'-cyclic phosphate [CPD:C20567];
H2O [CPD:C00001]
Product
7,8-dihydroneopterin 3'-phosphate [CPD:C05925];
7,8-dihydroneopterin 2'-phosphate [CPD:C20566]
Comment
Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2',3'-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2'-phosphate and 7,8-dihydroneopterin 3'-phosphate at a ratio of 4:1.
History
EC 3.1.4.56 created 2013
Orthology
K17487  
7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MKA: 
IAG: 
THG: 
HBU: 
PFM: 
PDL: 
BARB: 
 » show all
Taxonomy
Reference
1  [PMID:19746965]
  Authors
Mashhadi Z, Xu H, White RH
  Title
An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis.
  Journal
Biochemistry. 48 (2009) 9384-92.
  Sequence
[mja:MJ_0837]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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