KEGG   ENZYME: 3.1.4.57Help
Entry
EC 3.1.4.57                 Enzyme                                 

Name
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase;
cyclic phosphate dihydrolase;
phnPP (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase
Reaction(IUBMB)
(1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate [RN:R10972];
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate [RN:R10973]
Reaction(KEGG)
Substrate
5-phospho-alpha-D-ribose 1,2-cyclic phosphate [CPD:C20440];
H2O [CPD:C00001];
D-ribofuranose 2,5-bisphosphate
Product
D-ribofuranose 2,5-bisphosphate;
D-ribofuranose 5-phosphate;
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.
History
EC 3.1.4.57 created 2014
Reference
1  [PMID:24147537]
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis  of both ester bonds to phosphorus.
  Journal
J. Am. Chem. Soc. 135 (2013) 16360-3.
  Sequence
[ele:Elen_0235]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system