KEGG   ENZYME: 3.1.6.12Help
Entry
EC 3.1.6.12                 Enzyme                                 
Name
N-acetylgalactosamine-4-sulfatase;
chondroitinsulfatase;
chondroitinase;
arylsulfatase B;
acetylgalactosamine 4-sulfatase;
N-acetylgalactosamine 4-sulfate sulfohydrolase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate [RN:R07823]
Reaction(KEGG)
R07823(G)
Show
Comment
Acts also on N-acetylglucosamine 4-sulfate.
History
EC 3.1.6.12 created 1984
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01135  
arylsulfatase B
Genes
HSA: 
411(ARSB)
PTR: 
737316(ARSB)
PPS: 
100987929(ARSB)
GGO: 
PON: 
100457196(ARSB)
MCC: 
709136(ARSB)
MCF: 
102116401(ARSB)
MMU: 
11881(Arsb)
RNO: 
25227(Arsb)
CGE: 
100759794(Arsb)
HGL: 
101719731(Arsb)
TUP: 
102469500(ARSB)
CFA: 
610364(ARSB)
AML: 
100467836
FCA: 
100216331(ARSB)
PTG: 
102963642(ARSB)
BTA: 
538401(ARSB)
BOM: 
102279001(ARSB)
PHD: 
102335024(ARSB)
CHX: 
102189402(ARSB)
SSC: 
102158016(ARSB)
CFR: 
102507706(ARSB)
ECB: 
100073268(ARSB)
MYB: 
102252145(ARSB)
MYD: 
102758054(ARSB)
PALE: 
102887255(ARSB)
MDO: 
100032622(ARSB)
SHR: 
100931900(ARSB)
OAA: 
100088121(ARSB)
GGA: 
771459(ARSB)
TGU: 
100228383(ARSB)
FAB: 
101813661(ARSB)
PHI: 
102102961(ARSB)
FPG: 
101910790(ARSB)
FCH: 
102049359(ARSB)
CLV: 
102091560(ARSB)
ASN: 
102377963(ARSB)
PSS: 
102445150(ARSB)
ACS: 
100564703(arsb)
XTR: 
100493013(arsb)
DRE: 
100538007
TRU: 
101061832
MZE: 
101485324
OLA: 
101169377
XMA: 
102227522
LCM: 
102353782(ARSB)
BFO: 
BRAFLDRAFT_206928
CIN: 
100187202
SPU: 
574733 583464
DME: 
Dmel_CG7402 Dmel_CG8646
PTI: 
PHATRDRAFT_42934
EHX: 
EMIHUDRAFT_73553
RBA: 
RB1475(arsB) RB198 RB348 RB5417
 » show all
Taxonomy
Reference
1  [PMID:976430]
  Authors
Farooqui AA.
  Title
The desulphation of hexosamine sulphates by arylsulphatase B.
  Journal
Experientia. 32 (1976) 1242-4.
  Organism
Bos taurus
Reference
2  [PMID:738706]
  Authors
Gorham SD, Cantz M.
  Title
Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 359 (1978) 1811-4.
  Organism
Homo sapiens
Reference
3  [PMID:7370276]
  Authors
Tsuji M, Nakanishi Y, Habuchi H, Ishihara K, Suzuki S.
  Title
The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase.
  Journal
Biochim. Biophys. Acta. 612 (1980) 373-83.
  Organism
Bos taurus, Gallus gallus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55354-43-3
DBGET integrated database retrieval system