KEGG   ENZYME: 3.1.6.13Help
Entry
EC 3.1.6.13                 Enzyme                                 
Name
iduronate-2-sulfatase;
chondroitinsulfatase;
idurono-2-sulfatase;
iduronide-2-sulfate sulfatase;
L-iduronosulfatase;
L-idurono sulfate sulfatase;
iduronate sulfatase;
sulfo-L-iduronate sulfatase;
L-iduronate 2-sulfate sulfatase;
sulfoiduronate sulfohydrolase;
2-sulfo-L-iduronate 2-sulfatase;
iduronate-2-sulfate sulfatase;
iduronate sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
L-iduronate-2-sulfate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821]
Reaction(KEGG)
R07812(G) R07821(G)
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Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01136  
iduronate 2-sulfatase
Genes
HSA: 
3423(IDS)
PTR: 
465896(IDS)
PPS: 
GGO: 
PON: 
MCC: 
700892(IDS)
MMU: 
15931(Ids)
RNO: 
363513(Ids)
CFA: 
492194(IDS)
AML: 
FCA: 
101081450(IDS)
BTA: 
541272(IDS)
SSC: 
100512880(IDS)
MDO: 
100025173(IDS)
SHR: 
100932918(IDS)
OAA: 
100081812
GGA: 
422392(IDS)
MGP: 
100548552(IDS)
TGU: 
100231299(IDS)
ACS: 
100565846
XTR: 
100135738(ids)
DRE: 
559959(ids)
TRU: 
101066362
OLA: 
101158287
BFO: 
BRAFLDRAFT_117073
CIN: 
100185385
SPU: 
579992(ids) 584730 587680 588631
DME: 
Dmel_CG12014
DPO: 
Dpse_GA11337
DAN: 
Dana_GF24210
DER: 
Dere_GG15139
DPE: 
Dper_GL13249
DSE: 
Dsec_GM14572
DSI: 
Dsim_GD13763
DWI: 
Dwil_GK20513
DYA: 
Dyak_GE21364
DGR: 
Dgri_GH16111 Dgri_GH23326
DMO: 
Dmoj_GI12380
DVI: 
Dvir_GJ12270
AGA: 
AgaP_AGAP005778
AAG: 
AaeL_AAEL001757
CQU: 
CpipJ_CPIJ004938
AME: 
724550
NVI: 
100119376(NV15054)
TCA: 
655669
PHU: 
Phum_PHUM557360
NVE: 
NEMVE_v1g214238
AQU: 
100638175
MBR: 
MONBRDRAFT_22994
RBA: 
RB10612 RB110 RB11127(ids) RB2085(betC) RB2254 RB2707 RB3755 RB5424 RB763
 » show all
Taxonomy
Reference
1  [PMID:6816283]
  Authors
Archer IM, Harper PS, Wusteman FS.
  Title
Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids.
  Journal
Biochim. Biophys. Acta. 708 (1982) 134-40.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:4269173]
  Authors
Bach G, Eisenberg F Jr, Cantz M, Neufeld EF.
  Title
The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 2134-8.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:6945876]
  Authors
Di Natale P, Ronsisvalle L.
  Title
Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta.
  Journal
Biochim. Biophys. Acta. 661 (1981) 106-11.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:6950934]
  Authors
Yutaka T, Fluharty AL, Stevens RL, Kihara H.
  Title
Purification and some properties of human liver iduronate sulfatase.
  Journal
J. Biochem. (Tokyo). 91 (1982) 433-41.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50936-59-9
DBGET integrated database retrieval system