KEGG   ENZYME: 3.1.6.15Help
Entry
EC 3.1.6.15                 Enzyme                                 

Name
N-sulfoglucosamine-3-sulfatase;
chondroitinsulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-sulfo-3-sulfoglucosamine 3-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin
Comment
The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue.
History
EC 3.1.6.15 created 1984, modified 1989
Reference
1  [PMID:3987694]
  Authors
Bruce JS, McLean MW, Long WF, Williamson FB.
  Title
Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate.
  Journal
Eur. J. Biochem. 148 (1985) 359-65.
Reference
2  [PMID:7396957]
  Authors
Leder IG.
  Title
A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate.
  Journal
Biochem. Biophys. Res. Commun. 94 (1980) 1183-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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