KEGG   ENZYME: 3.1.6.18Help
Entry
EC 3.1.6.18                 Enzyme                                 

Name
glucuronate-2-sulfatase;
glucurono-2-sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate [RN:R07817]
Reaction(KEGG)
R07817(G)
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Comment
Does not act on iduronate 2-sulfate residues (cf. EC 3.1.6.13 iduronate-2-sulfatase)
History
EC 3.1.6.18 created 1989
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Reference
1  [PMID:4019466]
  Authors
Shaklee PN, Glaser JH, Conrad HE.
  Title
A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans.
  Journal
J. Biol. Chem. 260 (1985) 9146-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98597-45-6

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