KEGG   ENZYME: 3.1.6.8Help
Entry
EC 3.1.6.8                  Enzyme                                 
Name
cerebroside-sulfatase;
arylsulfatase A;
cerebroside sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
cerebroside-3-sulfate 3-sulfohydrolase
Reaction(IUBMB)
a cerebroside 3-sulfate + H2O = a cerebroside + sulfate [RN:R04856 R06280]
Reaction(KEGG)
Substrate
cerebroside 3-sulfate [CPD:C06125];
H2O [CPD:C00001]
Product
cerebroside [CPD:C02686];
sulfate [CPD:C00059]
Comment
Hydrolyses galactose-3-sulfate residues in a number of lipids. Also hydrolyses ascorbate 2-sulfate and many phenol sulfates.
Pathway
Sphingolipid metabolism
Orthology
K01134  
arylsulfatase A
Genes
HSA: 
410(ARSA)
PTR: 
458946(ARSA)
PPS: 
100978823(ARSA)
GGO: 
101143133(ARSA)
PON: 
100446820(ARSA)
MCC: 
716500(ARSA)
MMU: 
11883(Arsa)
RNO: 
315222(Arsa)
CFA: 
474457(ARSA)
AML: 
FCA: 
101083690(ARSA)
BTA: 
505514(ARSA)
SSC: 
396973(AS-A)
ECB: 
100056911
MDO: 
100012344(ARSA)
SHR: 
100930631(ARSA)
OAA: 
100091052
GGA: 
426863(ARSA)
MGP: 
100539178
ACS: 
100558774
XLA: 
447252(arsa.1)
XTR: 
100486429 100487749
DRE: 
541416(arsa)
TRU: 
101072550
OLA: 
101159667
SPU: 
574839 583591 583611 592372 593966
AQU: 
100638774
RBA: 
RB10116(arsA) RB12325 RB12432 RB409 RB4784(aslA) RB4815 RB6873 RB6956 RB7481(arsA) RB7995(arsA) RB8078(arsA) RB9192(arsA) RB9755(arsA)
HMA: 
rrnAC0858
 » show all
Taxonomy
Reference
1  [PMID:5829234]
  Authors
Mehl E, Jatzkewitz H.
  Title
[A cerebrosidesulfatase from swine kidney]
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 339 (1964) 260-76.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:13772]
  Authors
Roy AB.
  Title
Sulphatases, lysosomes and disease.
  Journal
Aust. J. Exp. Biol. Med. Sci. 54 (1976) 111-35.
  Organism
Homo sapiens [GN:hsa], Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-68-2
DBGET integrated database retrieval system