KEGG   ENZYME: 3.1.6.9Help
Entry
EC 3.1.6.9                  Enzyme                                 

Name
chondro-4-sulfatase;
chondroitin-4-sulfatase;
4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Reaction(IUBMB)
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate [RN:R03517]
Reaction(KEGG)
Substrate
4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate [CPD:C04864];
H2O [CPD:C00001]
Product
4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine [CPD:C01310];
sulfate [CPD:C00059]
Comment
Also acts on the saturated analogue but not on higher oligosaccharides, nor any 6-sulfates.
History
EC 3.1.6.9 created 1972
Reference
1  [PMID:5595107]
  Authors
Held E, Buddecke E.
  Title
[Studies on the chemistry of the arterial wall, XI. Demonstration, purification and properties of a chondroitin-4-sulfatase from bovine aorta]
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 348 (1967) 1047-60.
Reference
2  [PMID:13772]
  Authors
Roy AB.
  Title
Sulphatases, lysosomes and disease.
  Journal
Aust. J. Exp. Biol. Med. Sci. 54 (1976) 111-35.
Reference
3  [PMID:5647268]
  Authors
Yamagata T, Saito H, Habuchi O, Suzuki S.
  Title
Purification and properties of bacterial chondroitinases and chondrosulfatases.
  Journal
J. Biol. Chem. 243 (1968) 1523-35.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9045-75-4

DBGET integrated database retrieval system