KEGG   ENZYME: 3.1.7.5Help
Entry
EC 3.1.7.5                  Enzyme                                 

Name
geranylgeranyl diphosphate diphosphatase;
geranylgeranyl diphosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = geranylgeraniol + diphosphate [RN:R08993]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
geranylgeraniol [CPD:C09094];
diphosphate [CPD:C00013]
Comment
Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis.
History
EC 3.1.7.5 created 2009
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Reference
1  [PMID:16445953]
  Authors
Nualkaew N, De-Eknamkul W, Kutchan TM, Zenk MH
  Title
Membrane-bound geranylgeranyl diphosphate phosphatases: purification and characterization from Croton stellatopilosus leaves.
  Journal
Phytochemistry. 67 (2006) 1613-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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