KEGG   ENZYME: 3.1.7.9Help
Entry
EC 3.1.7.9                  Enzyme                                 

Name
isotuberculosinol synthase;
Rv3378c
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
BRITE hierarchy
Sysname
tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming)
Reaction(IUBMB)
tuberculosinyl diphosphate + H2O = (13S)-isotuberculosinol + diphosphate [RN:R09829]
Reaction(KEGG)
Substrate
tuberculosinyl diphosphate [CPD:C19836];
H2O [CPD:C00001]
Product
(13S)-isotuberculosinol [CPD:C19964];
diphosphate [CPD:C00013]
Comment
Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives tuberculosinol in 1:1 mixture, cf. EC 3.1.7.8, tuberculosinol synthase. The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively.
History
EC 3.1.7.9 created 2011
Orthology
K15911  
tuberculosinol/isotuberculosinol synthase
Genes
AGE: 
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MTQ: 
MBO: 
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MCQ: 
MCV: 
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 » show all
Taxonomy
Reference
1  [PMID:21228491]
  Authors
Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T
  Title
Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.
  Journal
Biosci. Biotechnol. Biochem. 75 (2011) 75-81.
  Sequence
[mtu:Rv3378c]
Reference
2  [PMID:21290071]
  Authors
Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T.
  Title
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and  the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis.
  Journal
Org. Biomol. Chem.  (2011) .
  Sequence
[mtu:Rv3378c]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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