KEGG ENZYME: 3.13.1.5

ENZYME: 3.13.1.5

Entry

EC 3.13.1.5                 Enzyme

Name

carbon disulfide hydrolase;
CS2 hydrolase (misleading);
carbon disulfide lyase;
CS2-converting enzyme;
carbon disulphide-lyase (decarboxylating)

Class

Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds

Sysname

carbon-disulfide hydrogen-sulfide-lyase (decarboxylating)

Reaction(IUBMB)

carbon disulfide + 2 H2O = CO2 + 2 hydrogen sulfide (overall reaction) [RN:R10538];
(1a) carbon disulfide + H2O = carbonyl sulfide + hydrogen sulfide [RN:R10534];
(1b) carbonyl sulfide + H2O = CO2 + hydrogen sulfide [RN:R10535]

Reaction(KEGG)

R10534 R10535 R10538

Substrate

carbon disulfide [CPD:C19033];
H2O [CPD:C00001];
carbonyl sulfide [CPD:C07331]

Product

CO2 [CPD:C00011];
hydrogen sulfide [CPD:C00283];
carbonyl sulfide [CPD:C07331]

Comment

The enzyme contains Zn2+. The hyperthermophilic archaeon Acidianus sp. A1-3 obtains energy by the conversion of carbon disulfide to hydrogen sulfide, with carbonyl sulfide as an intermediate.

History

EC 3.13.1.5 created 2013 as EC 4.4.1.27, transferred 2017 to EC 3.13.1.5

Orthology

K20499

carbon disulfide hydrolase

Genes

HYI:	K2M58_03690

SSO:

SSO1214

SCAS:

SACC_25390

SIS:	LS215_0963

SIH:

SiH_0575

SULL:

EWF20_11055

MJN:	MjAS7_0130

ABRI:

DFR85_14675

Reference

1 [PMID:22012399]

Authors

Smeulders MJ, Barends TR, Pol A, Scherer A, Zandvoort MH, Udvarhelyi A, Khadem AF, Menzel A, Hermans J, Shoeman RL, Wessels HJ, van den Heuvel LP, Russ L, Schlichting I, Jetten MS, Op den Camp HJ

Title

Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon.

Journal

Nature 478:412-6 (2011)
DOI:10.1038/nature10464

Sequence

[ag:AEL19654]

Other DBs

ExplorEnz - The Enzyme Database:

3.13.1.5

IUBMB Enzyme Nomenclature:

3.13.1.5

ExPASy - ENZYME nomenclature database:

3.13.1.5

BRENDA, the Enzyme Database:

3.13.1.5

DBGET integrated database retrieval system