KEGG   ENZYME: 3.2.1.123Help
Entry
EC 3.2.1.123                Enzyme                                 

Name
endoglycosylceramidase;
endoglycoceramidase;
EGCase;
glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase, oligoglycosylglucosylceramide glycohydrolase;
oligoglycosylglucosyl(1<->1)ceramide glycohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
oligoglycosylglucosyl-(1<->1)-ceramide glycohydrolase
Reaction(IUBMB)
oligoglycosylglucosyl-(1<->1)-ceramide + H2O = ceramide + oligoglycosylglucose [RN:R04118 R06157]
Reaction(KEGG)
R04118 R06157(G);
(other) R06283(G)
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Substrate
oligoglycosylglucosyl-(1<->1)-ceramide;
H2O [CPD:C00001]
Product
ceramide [CPD:C00195];
oligoglycosylglucose [CPD:C03018]
Comment
An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase.
History
EC 3.2.1.123 created 1989
Orthology
K05991  
endoglycosylceramidase
Genes
BFO: 
HRO: 
SMM: 
NVE: 
HMG: 
100192295(egcase)
AQU: 
PPP: 
CSL: 
MAW: 
MAJ: 
CMT: 
AFM: 
AOR: 
AOR_1_10194(AO090012000006)
AFV: 
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ARM: 
PAC: 
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PAV: 
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PACC: 
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 » show all
Taxonomy
Reference
1  [PMID:3771534]
  Authors
Ito M, Yamagata T.
  Title
A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids.
  Journal
J. Biol. Chem. 261 (1986) 14278-82.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
105503-61-5

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