Entry
Name
amylo-alpha-1,6-glucosidase;
amylo-1,6-glucosidase;
dextrin 6-alpha-D-glucosidase;
amylopectin 1,6-glucosidase;
dextrin-1,6-glucosidase;
glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase
Reaction(IUBMB)
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin
Reaction(KEGG)
Comment
This enzyme hydrolyses an unsubstituted glucose unit linked by an alpha(1->6) bond to an alpha(1->4) glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC
2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.
History
EC 3.2.1.33 created 1965, modified 2000
Orthology
K01196 glycogen debranching enzyme
Genes
XLA : 108715682(agl.S) 779381(agl.L)
SRX : 107712821 107718145 107722579 107739006
SANH : 107693749(agl) 107697901
SGH : 107548909 107589898 107590314 107590315 107594650(agl)
CCAR : 109053523 109110256
CAUA : 113045793 113093821 113115849
CGIB : 127946579 127950883 128027313
PTET : 122329716 122360388(agla)
LROH : 127153412(agla) 127155957
OMC : 131531982(agla) 131533240
PPRM : 120478505 120481972(agla)
MAMB : 125251584(agla) 125257930
CIDE : 127495486 127497175 127505832
MASI : 127431457 127434456 127440386 127442395
TROS : 130546868 130554663(agla)
TDW : 130413673 130417401(agla)
MANU : 129426605 129442383(agla)
IPU : 108272764 108277899(agla)
IFU : 128605345 128621281(agla)
PHYP : 113533703 113539206(agl)
SMEO : 124384950 124394637(agla)
TFD : 113643453(agla) 113663728
TVC : 132846448 132857843(agla)
AMEX : 103029371 103032775
CMAO : 118804701(agla) 118822010
EEE : 113586563 113588063(agl)
NCC : 104947281 104957520(agl)
CGOB : 115022457 115025484
GACU : 117540022 117559810
SLUC : 116043967(agla) 116055780
ECRA : 117937719 117953970
PFLV : 114549238 114565141(agl)
CVG : 107099264 107103298(agl)
ALIM : 106510843 106523907
SSEN : 122759958 122772849 122781471
SDU : 111233892(agl) 111237619
SLAL : 111648380(agl) 111665497
SJO : 128368814(agla) 128382386
SASA : 106568905 106578509 106599117
STRU : 115153237 115156796 115169902
OTW : 112215549 112227058(agla) 112260354
OMY : 110508855(agla) 110530174 110535501
ONE : 115103201 115105065 115114284
OKI : 109871886 109875299 109909980
OKE : 118361609 118394547 118402238
SALP : 111956742 111973033 111978993
SNH : 120020446 120028117 120055831
CCLU : 121535098 121549916 121580813(agla)
AANG : 118226618 118230160(agla)
PSPA : 121326705 121330871
ARUT : 117412199 117417034
LPIC : 129270722 129270726
DSI : Dsimw501_GD11587(Dsim_GD11587)
AALB : 109427995 115268733
CQU : CpipJ_CPIJ013040 CpipJ_CPIJ020026
APLN : 108734200 112905727
PPOI : 119107223 119107310
CBR : CBG_11104(Cbr-agl-1)
BMY : BM_BM5241(Bma-agl-1)
LOA : LOAG_07652 LOAG_11769
NCS : NCAS_0A15250(NCAS0A15250)
NDI : NDAI_0J00180(NDAI0J00180)
TPF : TPHA_0I03290(TPHA0I03290)
TBL : TBLA_0J00110(TBLA0J00110)
TDL : TDEL_0H00300(TDEL0H00300)
KAF : KAFR_0B00300(KAFR0B00300)
KNG : KNAG_0F03960(KNAG0F03960)
CAL : CAALFM_C405140CA(GDB1)
NTE : NEUTE1DRAFT149613(NEUTE1DRAFT_149613)
VAL : VDBG_05054 VDBG_05055
BFU : BCIN_01g10310(Bcgdb1)
PBL : PAAG_12154(PAAG_06098)
CCAC : CcaHIS019_0304080(GDB1)
ABP : AGABI1DRAFT118950(AGABI1DRAFT_118950)
ABV : AGABI2DRAFT206172(AGABI2DRAFT_206172)
MPR : MPER_03030 MPER_11198
SCM : SCHCO_02598145(SCHCODRAFT_02598145)
EHI : EHI_098360(77.t00009)
EIV : EIN_064680 EIN_175730
TET : TTHERM_000128319 TTHERM_00128330
PTM : GSPATT00025969001 GSPATT00028373001 GSPATT00032669001
SMIN : v1.2.030503.t1(symbB.v1.2.030503.t1)
TVA : TVAG_2v0353620 TVAG_2v0583500 TVAG_2v0978730
» show all
Taxonomy
Reference
1
Authors
Brown, D.H. and Brown, B.I.
Title
Enzymes of glycogen debranching: Amylo-1,6-glucosidase (I) and oligo-1,4->1,4-glucanotransferase (II).
Journal
Methods Enzymol 8:515-524 (1966)
Reference
Authors
Lee EY, Carter JH, Nielsen LD, Fischer EH.
Title
Purification and properties of yeast amylo-1,6-glucosidase--oligo-1,4 leads to 1,4-glucantransferase.
Journal
Reference
Authors
Nelson TE, Kolb E, Larner J.
Title
Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.33
ExPASy - ENZYME nomenclature database: 3.2.1.33