KEGG   ENZYME: 3.2.1.47Help
Entry
EC 3.2.1.47                 Enzyme                                 

Name
galactosylgalactosylglucosylceramidase;
trihexosyl ceramide galactosidase;
ceramide trihexosidase;
ceramidetrihexoside alpha-galactosidase;
trihexosylceramide alpha-galactosidase;
ceramidetrihexosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide galactohydrolase
Reaction(IUBMB)
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = D-galactose + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03618 R05961]
Reaction(KEGG)
R03618 R05961(G);
(other) R06136(G)
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Substrate
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
History
EC 3.2.1.47 created 1972, modified 2011
Pathway
Glycosphingolipid biosynthesis - globo series
Reference
1  [PMID:6020428]
  Authors
Brady RO, Gal AE, Bradley RM, Martensson E.
  Title
The metabolism of ceramide trihexosides. I. Purification and properties of an enzyme that cleaves the terminal galactose molecule of galactosylgalactosylglucosylceramide.
  Journal
J. Biol. Chem. 242 (1967) 1021-6.
  Organism
Rattus norvegicus
Reference
2  [PMID:11946769]
  Authors
Mapes CA, Sweeley CC
  Title
Substrate specificity of ceramide trihexosidase.
  Journal
FEBS. Lett. 25 (1972) 279-281.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9023-01-2

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