KEGG   ENZYME: 3.2.2.19Help
Entry
EC 3.2.2.19                 Enzyme                                 

Name
[protein ADP-ribosylarginine] hydrolase;
ADP-ribose-L-arginine cleavage enzyme;
ADP-ribosylarginine hydrolase;
Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase;
protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
Reaction(IUBMB)
(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine [RN:R07626];
(2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine [RN:R01886]
Reaction(KEGG)
Substrate
protein-Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C16011];
H2O [CPD:C00001];
Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C01201]
Product
ADP-D-ribose [CPD:C00301];
protein-L-arginine [CPD:C00613];
L-arginine [CPD:C00062]
Comment
The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins.
History
EC 3.2.2.19 created 1989, modified 2004
Orthology
K01245  
ADP-ribosylarginine hydrolase
Genes
HSA: 
141(ADPRH)
PTR: 
470893(ADPRH)
PPS: 
100968536(ADPRH)
GGO: 
101150307(ADPRH)
PON: 
100440790(ADPRH)
NLE: 
100602502(ADPRH)
MCC: 
712562(ADPRH)
MCF: 
102138957(ADPRH)
RRO: 
104657619(ADPRH)
CJC: 
100391892(ADPRH)
MMU: 
11544(Adprh)
RNO: 
25371(Adprh)
CGE: 
100761196(Adprh)
NGI: 
103741941(Adprh)
HGL: 
101705433(Adprh)
OCU: 
100354201(ADPRH)
TUP: 
102473277(ADPRH)
CFA: 
100855709(ADPRH)
AML: 
100479971(ADPRH)
UMR: 
103678790(ADPRH)
BTA: 
525738(ADPRH)
BOM: 
102277051(ADPRH)
PHD: 
102338571(ADPRH)
CHX: 
102168665(ADPRH)
OAS: 
101106222(ADPRH)
SSC: 
100153158(ADPRH)
CFR: 
102524560(ADPRH)
BACU: 
103002571(ADPRH)
LVE: 
103086426(ADPRH)
ECB: 
100070997(ADPRH)
MYB: 
102245153(ADPRH)
MYD: 
102755321(ADPRH)
PALE: 
102881506(ADPRH)
MDO: 
100016348(ADPRH)
SHR: 
100927416(ADPRH)
GGA: 
426545(ADPRHL)
MGP: 
APLA: 
101795135(ADPRH)
TGU: 
100226233(ADPRH)
GFR: 
102040950(ADPRH)
FAB: 
PHI: 
CCW: 
FPG: 
101915329(ADPRH)
FCH: 
102058856(ADPRH)
CLV: 
ASN: 
102386159(ADPRH)
AMJ: 
PSS: 
102452391(ADPRH)
CMY: 
102934922(ADPRH)
ACS: 
PBI: 
XLA: 
432184 495095(adprh)
XTR: 
100135190(adprh) 493544(adprh)
DRE: 
445059(adprh)
TRU: 
MZE: 
101482423(adprh)
OLA: 
101172847(adprh)
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
SKO: 
HRO: 
LGI: 
CRG: 
NVE: 
HMG: 
AQU: 
DDI: 
DPP: 
DFA: 
DFA_04483(adprh)
ACAN: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:2994036]
  Authors
Moss J, Jacobson MK, Stanley SJ.
  Title
Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 5603-7.
Reference
2  [PMID:1375222]
  Authors
Moss J, Stanley SJ, Nightingale MS, Murtagh JJ Jr, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC.
  Title
Molecular and immunological characterization of ADP-ribosylarginine hydrolases.
  Journal
J. Biol. Chem. 267 (1992) 10481-8.
  Sequence
[rno:25371]
Reference
3  [PMID:10358013]
  Authors
Konczalik P, Moss J.
  Title
Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases.
  Journal
J. Biol. Chem. 274 (1999) 16736-40.
Reference
4  [PMID:8349667]
  Authors
Takada T, Iida K, Moss J.
  Title
Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.
  Journal
J. Biol. Chem. 268 (1993) 17837-43.
  Sequence
[hsa:141]
Reference
5  [PMID:8678289]
  Authors
Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M.
  Title
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
  Journal
Anal. Biochem. 231 (1995) 115-22.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98668-52-1

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