KEGG   ENZYME: 3.2.2.24Help
Entry
EC 3.2.2.24                 Enzyme                                 

Name
ADP-ribosyl-[dinitrogen reductase] hydrolase;
azoferredoxin glycosidase;
azoferredoxin-activating enzymes;
dinitrogenase reductase-activating glycohydrolase;
ADP-ribosyl glycohydrolase;
draG (gene name)
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
ADP-D-ribosyl-[dinitrogen reductase] ADP-ribosylhydrolase
Reaction(IUBMB)
[dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + [dinitrogen reductase]-L-arginine [RN:R03446]
Reaction(KEGG)
Substrate
[dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine [CPD:C01253]
Product
ADP-D-ribose [CPD:C00301];
[dinitrogen reductase]-L-arginine [CPD:C03315]
Comment
The enzyme restores the activity of EC 1.18.6.1, nitrogenase, by catalysing the removal of ADP-ribose from an arginine residue of the dinitrogenase reductase component of nitrogenase. This activity occurs only when the nitrogenase product, ammonium, is not available. The combined activity of this enzyme and EC 2.4.2.37, NAD+-dinitrogen-reductase ADP-D-ribosyltransferase, controls the level of activity of nitrogenase.
History
EC 3.2.2.24 created 1992
Orthology
K05521  
ADP-ribosyl-[dinitrogen reductase] hydrolase
Genes
SPE: 
BTO: 
BTRE: 
BTRH: 
BTRA: 
XCC: 
XCC2928(draG)
XCB: 
XCA: 
SMZ: 
PPF: 
PPW: 
PPT: 
PPI: 
PPX: 
PPUH: 
PPUN: 
PMON: 
PMOT: 
PFL: 
PPRC: 
PFO: 
PBA: 
SSE: 
TTU: 
MMT: 
ALV: 
TVI: 
TMB: 
HHC: 
TAU: 
PNA: 
RGE: 
RGE_42850(draG)
AZO: 
azo0530(draG1)
AZA: 
AZKH_0794(draG)
DAR: 
DSU: 
APP: 
SLT: 
GSU: 
GSU2800(draG)
GSK: 
GME: 
Gmet_0680(draG)
GUR: 
GLO: 
GBM: 
Gbem_2082(draG)
GEO: 
Geob_2589(draG)
GEM: 
GEB: 
PCA: 
Pcar_2093(draG)
PPD: 
DAT: 
HRM2_09820(draG1)
AFW: 
RPA: 
RPA2406(draG)
RPB: 
RPC: 
RPD: 
RPE: 
RPT: 
RPX: 
MEX: 
MDI: 
RSQ: 
RCP: 
NAR: 
RRU: 
RRF: 
RPM: 
MAG: 
MGY: 
AZL: 
ALI: 
ABS: 
MGM: 
AFE: 
AFR: 
AFE_1525(draG)
AFI: 
GJF: 
PJD: 
GYM: 
PPY: 
PPO: 
PPM_3580(draG)
PMS: 
PMQ: 
PMW: 
PTA: 
PSAB: 
CLJ: 
CAH: 
CCL: 
RUM: 
STH: 
DAE: 
DKU: 
TJR: 
DED: 
DEC: 
DRS: 
ADG: 
TTM: 
TTO: 
TSH: 
FMA: 
MMAR: 
RRD: 
AMR: 
ATM: 
ANT_00250(draG)
TOS: 
CCZ: 
TTR: 
CAA: 
DIN: 
DAP: 
CNI: 
TID: 
MZH: 
MPL: 
NPH: 
HUT: 
HTI: 
HLA: 
HBO: 
NGE: 
SALI: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:2506427]
  Authors
Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP.
  Title
Genes coding for the reversible ADP-ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum.
  Journal
Mol. Gen. Genet. 218 (1989) 340-7.
  Sequence
[rru:Rru_A1008]
Reference
2  [PMID:19477184]
  Authors
Li XD, Huergo LF, Gasperina A, Pedrosa FO, Merrick M, Winkler FK
  Title
Crystal structure of dinitrogenase reductase-activating glycohydrolase (DraG) reveals conservation in the ADP-ribosylhydrolase fold and specific features in the ADP-ribose-binding pocket.
  Journal
J. Mol. Biol. 390 (2009) 737-46.
Reference
3  [PMID:19706507]
  Authors
Berthold CL, Wang H, Nordlund S, Hogbom M
  Title
Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 14247-52.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
125626-63-3

DBGET integrated database retrieval system