KEGG   ENZYME: 3.2.2.30Help
Entry
EC 3.2.2.30                 Enzyme                                 

Name
aminodeoxyfutalosine nucleosidase;
AFL nucleosidase;
aminofutalosine nucleosidase;
methylthioadenosine nucleosidase;
MqnB
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
6-amino-6-deoxyfutalosine ribohydrolase
Reaction(IUBMB)
6-amino-6-deoxyfutalosine + H2O = dehypoxanthine futalosine + adenine [RN:R10668]
Reaction(KEGG)
Substrate
6-amino-6-deoxyfutalosine [CPD:C20773];
H2O [CPD:C00001]
Product
dehypoxanthine futalosine [CPD:C17010];
adenine [CPD:C00147]
Comment
The enzyme, found in several bacterial species, catalyses a step in a modified futalosine pathway for menaquinone biosynthesis. While the enzyme from some organisms also has the activity of EC 3.2.2.9, adenosylhomocysteine nucleosidase, the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine [7].
History
EC 3.2.2.30 created 2014
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K18284  
adenosylhomocysteine/aminodeoxyfutalosine nucleosidase
Genes
FTU: 
FTQ: 
RO31_0445(mtnN)
FTF: 
FTF0397(mtn)
FTW: 
FTW_1677(mtnN)
FTR: 
FTT: 
FTY: 
CH70_1569(mtnN)
FTG: 
FTL: 
FTH: 
FTA: 
FTA_0491(mtnN)
FTS: 
FTI: 
FTO: 
FTC: 
DA46_231(mtnN)
FTV: 
CH67_765(mtnN)
FTZ: 
CH68_499(mtnN)
FTM: 
FTN: 
FTX: 
AW25_1535(mtnN)
FTD: 
AS84_190(mtnN)
FCF: 
FCN: 
FPH: 
FPT: 
BZ13_1707(mtnN)
FPI: 
BF30_535(mtnN)
FPM: 
LA56_1828(mtnN)
FPX: 
KU46_1019(mtnN)
FPZ: 
LA55_485(mtnN)
FPJ: 
LA02_1973(mtnN)
FRT: 
FNA: 
FNL: 
FRF: 
FPER: 
HPY: 
HEO: 
HPJ: 
HPA: 
HPS: 
HHP: 
HHQ: 
HHR: 
HPG: 
HPP: 
HPB: 
HPL: 
HPC: 
HCA: 
HPM: 
HPE: 
HPO: 
HPI: 
HPQ: 
HPW: 
HPU: 
HEF: 
HPF: 
HEQ: 
HEX: 
HPT: 
HPZ: 
HPV: 
HPX: 
HEN: 
HPH: 
HEG: 
HPN: 
HEP: 
HEU: 
HES: 
HPYS: 
HCN: 
HPD: 
HEY: 
HER: 
HEI: 
HPYA: 
HPYK: 
HPYO: 
HPYL: 
HPYB: 
HPYC: 
HPYD: 
HPYE: 
HPYF: 
HPYG: 
HPYH: 
HPYJ: 
HPYR: 
HPYI: 
HPYU: 
HPYM: 
HEM: 
HEB: 
HEZ: 
HHE: 
HAC: 
HMS: 
HFE: 
HBI: 
HCE: 
HCM: 
HCP: 
HCB: 
HHM: 
HTY: 
WSU: 
WS0528(PFS)
TDN: 
SUA: 
SKU: 
SULR: 
CJE: 
Cj0117(pfs)
CJB: 
CJJ: 
CJU: 
CJN: 
CJI: 
CJSA_0108(mtnA)
CJM: 
CJM1_0116(mtnN)
CJS: 
CJS3_0116(mtnA)
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJV: 
CJY: 
CJQ: 
CJL: 
CJW: 
CJR: 
CJE0112(mtnA)
CJD: 
CJZ: 
CJX: 
CFF: 
CFT: 
CFV: 
CFX: 
CFZ: 
CAMP: 
CFP: 
CCV: 
CHA: 
CCO: 
CLA: 
CLR: 
CLM: 
CLQ: 
CLN: 
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
CCOO: 
CAJ: 
CIS: 
CVO: 
CPEL: 
CAMR: 
CSM: 
CSF: 
CGRA: 
CURE: 
ABU: 
ABT: 
ABL: 
ANT: 
ARC: 
SDL: 
SBA: 
SMUL: 
SHAL: 
NSA: 
NIS: 
SUN: 
SLH: 
NAM: 
NAMH_0333(mtnN)
VIR: 
STA: 
 » show all
Taxonomy
Reference
1  [PMID:18801996]
  Authors
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T
  Title
An alternative menaquinone biosynthetic pathway operating in microorganisms.
  Journal
Science. 321 (2008) 1670-3.
Reference
2  [PMID:21489995]
  Authors
Li X, Apel D, Gaynor EC, Tanner ME
  Title
5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni.
  Journal
J. Biol. Chem. 286 (2011) 19392-8.
  Sequence
[cje:Cj0117]
Reference
3  [PMID:21098241]
  Authors
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T
  Title
Diversity of the early step of the futalosine pathway.
  Journal
Antimicrob. Agents. Chemother. 55 (2011) 913-6.
  Sequence
[hpy:HP0089]
Reference
4  [PMID:22891633]
  Authors
Wang S, Haapalainen AM, Yan F, Du Q, Tyler PC, Evans GB, Rinaldo-Matthis A, Brown RL, Norris GE, Almo SC, Schramm VL
  Title
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic  for Helicobacter pylori.
  Journal
Biochemistry. 51 (2012) 6892-4.
  Sequence
[hpj:jhp_0082]
Reference
5  [PMID:23148563]
  Authors
Mishra V, Ronning DR
  Title
Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
  Journal
Biochemistry. 51 (2012) 9763-72.
  Sequence
[hpj:jhp_0082]
Reference
6  [PMID:24419390]
  Authors
Kim RQ, Offen WA, Davies GJ, Stubbs KA
  Title
Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in  the futalosine pathway.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 70 (2014) 177-85.
  Sequence
[hpy:HP0089]
Reference
7  [PMID:25253688]
  Authors
Barta ML, Thomas K, Yuan H, Lovell S, Battaile KP, Schramm VL, Hefty PS
  Title
Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.
  Journal
J. Biol. Chem. 289 (2014) 32214-29.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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