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Entry
EC 3.2.2.30                 Enzyme                                 

Name
aminodeoxyfutalosine nucleosidase;
AFL nucleosidase;
aminofutalosine nucleosidase;
methylthioadenosine nucleosidase;
MqnB
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
6-amino-6-deoxyfutalosine ribohydrolase
Reaction(IUBMB)
6-amino-6-deoxyfutalosine + H2O = dehypoxanthine futalosine + adenine [RN:R10668]
Reaction(KEGG)
Substrate
6-amino-6-deoxyfutalosine [CPD:C20773];
H2O [CPD:C00001]
Product
dehypoxanthine futalosine [CPD:C17010];
adenine [CPD:C00147]
Comment
The enzyme, found in several bacterial species, catalyses a step in a modified futalosine pathway for menaquinone biosynthesis. While the enzyme from some organisms also has the activity of EC 3.2.2.9, adenosylhomocysteine nucleosidase, the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine [7].
History
EC 3.2.2.30 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K18284  adenosylhomocysteine/aminodeoxyfutalosine nucleosidase
Genes
FTU: FTT_0397(mtn)
FTQ: RO31_0445(mtnN)
FTF: FTF0397(mtn)
FTW: FTW_1677(mtnN)
FTR: NE061598_02215
FTT: FTV_0368(mtn)
FTY: CH70_1569(mtnN)
FTG: FTU_0452(mtn)
FTL: FTL_0463
FTH: FTH_0460
FTA: FTA_0491(mtnN)
FTS: F92_02515
FTI: FTS_0464(mtn)
FTC: DA46_231(mtnN)
FTV: CH67_765(mtnN)
FTZ: CH68_499(mtnN)
FTM: FTM_0552(mtn)
FTN: FTN_0493(mtn)
FTX: AW25_1535(mtnN)
FTD: AS84_190(mtnN)
FPH: Fphi_0356
FPT: BZ13_1707(mtnN)
FPI: BF30_535(mtnN)
FPM: LA56_1828(mtnN)
FPX: KU46_1019(mtnN)
FPZ: LA55_485(mtnN)
FPJ: LA02_1973(mtnN)
FNA: OOM_1055
HPY: HP0089
HPJ: jhp_0082
HPG: HPG27_82
HPL: HPB8_1476(pfs)
HPO: HMPREF4655_20365(mtnN)
HPZ: HPKB_0101
HPV: HPV225_0097(mtnN)
HPX: HMPREF0462_0142(mtnN)
HPYS: HPSA20_0103(mtnN)
HPD: KHP_0093(mtn)
HEY: MWE_0186
HPYR: K747_09260
HPYI: K750_09390
HPYU: K751_07190
HPYM: K749_05085
HEB: U063_0432
HEZ: U064_0433
HHE: HH_1283
HAC: Hac_1516
HMS: HMU14270(pfs)
HFE: HFELIS_05270(pfs)
HCE: HCW_02355
HCM: HCD_03510
HCP: HCN_1837
WSU: WS0528(PFS)
SUA: Saut_0788
SULR: B649_08230
CJE: Cj0117(pfs)
CJB: BN148_0117(pfs)
CJJ: CJJ81176_0152(mtnA)
CJU: C8J_0110(pfs)
CJI: CJSA_0108(mtnA)
CJM: CJM1_0116(mtnN)
CJS: CJS3_0116(mtnA)
CJEJ: N564_00110
CJEU: N565_00109
CJEN: N755_00109
CJEI: N135_00117
CJER: H730_00610
CJV: MTVDSCj20_0114(pfs)
CJY: QZ67_00123(pfs)
CJQ: UC78_0119(pfs)
CJR: CJE0112(mtnA)
CJD: JJD26997_0124(mtnA)
CFF: CFF8240_1515(mtnN)
CFT: CFF04554_1527(pfs)
CFV: CFVI03293_1549(pfs)
CFX: CFV97608_1649(pfs)
CFZ: CSG_16500
CAMP: CFT03427_1475(pfs)
CCV: CCV52592_1748(pfs)
CHA: CHAB381_0698(mtnN)
CCO: CCC13826_0927(pfs)
CCOC: CCON33237_0465(pfs)
CLA: Cla_0205(pfs)
CLR: UPTC16701_0211(pfs)
CLM: UPTC16712_0209(pfs)
CLQ: UPTC4110_0203(pfs)
CLN: UPTC3659_0222(pfs)
CLL: CONCH_0202(pfs)
CCQ: N149_1594
CCF: YSQ_09320
CCY: YSS_09350
CCOI: YSU_08315
CCOF: VC76_08155(pfs)
CCOO: ATE51_04230(pfs)
CAJ: CIG1485E_1465(pfs)
CIS: CINS_0195(pfs)
CVO: CVOL_0198(pfs)
CPEL: CPEL_0207(pfs)
CAMR: CAQ16704_0208(pfs)
CSM: CSUB8521_0212(pfs)
CSF: CSUB8523_0206(pfs)
CGRA: CGRAC_0395(pfs)
CURE: CUREO_0552(pfs)
CHYO: CHH_1553(pfs)
CHV: CHELV3228_0080(pfs)
CSPF: CSF_1509(pfs)
CPIN: CPIN18020_1200(pfs)
CCUN: CCUN_0474(pfs)
CLX: CLAN_1209(pfs)
ABU: Abu_1585(pfs)
ABT: ABED_1470
ABL: A7H1H_1589(pfs)
ARC: ABLL_2061
SDL: Sdel_0526
SMUL: SMUL_0698
SHAL: SHALO_0693
SULJ: SJPD1_0636
NIS: NIS_1209(pfs)
SUN: SUN_1755(pfs)
NAM: NAMH_0333(mtnN)
 » show all
Taxonomy
Reference
1  [PMID:18801996]
  Authors
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T
  Title
An alternative menaquinone biosynthetic pathway operating in microorganisms.
  Journal
Science. 321 (2008) 1670-3.
Reference
2  [PMID:21489995]
  Authors
Li X, Apel D, Gaynor EC, Tanner ME
  Title
5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni.
  Journal
J. Biol. Chem. 286 (2011) 19392-8.
  Sequence
[cje:Cj0117]
Reference
3  [PMID:21098241]
  Authors
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T
  Title
Diversity of the early step of the futalosine pathway.
  Journal
Antimicrob. Agents. Chemother. 55 (2011) 913-6.
  Sequence
[hpy:HP0089]
Reference
4  [PMID:22891633]
  Authors
Wang S, Haapalainen AM, Yan F, Du Q, Tyler PC, Evans GB, Rinaldo-Matthis A, Brown RL, Norris GE, Almo SC, Schramm VL
  Title
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic  for Helicobacter pylori.
  Journal
Biochemistry. 51 (2012) 6892-4.
  Sequence
[hpj:jhp_0082]
Reference
5  [PMID:23148563]
  Authors
Mishra V, Ronning DR
  Title
Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
  Journal
Biochemistry. 51 (2012) 9763-72.
  Sequence
[hpj:jhp_0082]
Reference
6  [PMID:24419390]
  Authors
Kim RQ, Offen WA, Davies GJ, Stubbs KA
  Title
Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in  the futalosine pathway.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 70 (2014) 177-85.
  Sequence
[hpy:HP0089]
Reference
7  [PMID:25253688]
  Authors
Barta ML, Thomas K, Yuan H, Lovell S, Battaile KP, Schramm VL, Hefty PS
  Title
Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.
  Journal
J. Biol. Chem. 289 (2014) 32214-29.
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.30
IUBMB Enzyme Nomenclature: 3.2.2.30
ExPASy - ENZYME nomenclature database: 3.2.2.30
BRENDA, the Enzyme Database: 3.2.2.30

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