KEGG   ENZYME: 3.2.2.5Help
Entry
EC 3.2.2.5                  Enzyme                                 
Name
NAD+ nucleosidase;
NADase;
DPNase;
DPN hydrolase;
NAD hydrolase;
diphosphopyridine nucleosidase;
nicotinamide adenine dinucleotide nucleosidase;
NAD glycohydrolase;
NAD nucleosidase;
nicotinamide adenine dinucleotide glycohydrolase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
NAD+ glycohydrolase
Reaction(IUBMB)
NAD+ + H2O = ADP-ribose + nicotinamide [RN:R00102]
Reaction(KEGG)
R00102;
(other) R00119
Show
Substrate
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
ADP-ribose [CPD:C00301];
nicotinamide [CPD:C00153]
Comment
This enzyme can also hydrolyse NADP+ to yield phospho-ADP-ribose and nicotinamide, but more slowly.
Pathway
Nicotinate and nicotinamide metabolism
Metabolic pathways
Orthology
K01242  
NAD+ nucleosidase
Genes
HSA: 
683(BST1) 952(CD38)
PTR: 
461126(BST1) 745433(CD38)
PPS: 
100972434(BST1) 100974952(CD38)
GGO: 
PON: 
100174150(BST1) 100457558(CD38)
MCC: 
714399(CD38)
MMU: 
12182(Bst1) 12494(Cd38)
RNO: 
25668(Cd38) 81506(Bst1)
CFA: 
403756(CD38) 488820(BST1)
AML: 
FCA: 
101101052(BST1) 101101308(CD38)
BTA: 
327677(CD38) 616757(BST1)
SSC: 
100511702(CD38) 100625942
ECB: 
100068959
MDO: 
100015733
SHR: 
100915627(BST1)
OAA: 
100074315 100079912
GGA: 
422827(CD38) 422828(BST1)
MGP: 
100546297 100548136
TGU: 
100224783(BST1) 101232999(CD38)
XLA: 
100036901(cd38) 100873156(cd38b)
XTR: 
496666(cd38)
TRU: 
101065178 101074837
OLA: 
101168159 101168676
SPU: 
100126187(arc3) 100859964(arc4) 576085(arc2) 580868(arc1)
NVE: 
NEMVE_v1g217601
HMG: 
100199121 100199929 100211840 100212165
TAD: 
TRIADDRAFT_19184 TRIADDRAFT_36890 TRIADDRAFT_51409
 » show all
Taxonomy
Reference
1  [PMID:13276383]
  Authors
HOFMANN EC, RAPOPORT S.
  Title
[DPN- and TPN-specific nucleosidases in erythrocytes.]
  Journal
Biochim. Biophys. Acta. 18 (1955) 296.
Reference
2  [PMID:5672131]
  Authors
Nakazawa K, Ueda K, Honjo T, Yoshihara K, Nishizuka Y, Hayaishi O.
  Title
Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver.
  Journal
Biochem. Biophys. Res. Commun. 32 (1968) 143-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:240831]
  Authors
Ueda K, Fukushima M, Okayama H, Hayaishi O.
  Title
Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme.
  Journal
J. Biol. Chem. 250 (1975) 7541-6.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:11866528]
  Authors
Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K.
  Title
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
  Journal
J. Mol. Biol. 316 (2002) 711-23.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-65-9
DBGET integrated database retrieval system