KEGG   ENZYME: 3.3.2.2Help
Entry
EC 3.3.2.2                  Enzyme                                 

Name
lysoplasmalogenase;
alkenylglycerophosphocholine hydrolase;
alkenylglycerophosphoethanolamine hydrolase;
1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
BRITE hierarchy
Sysname
lysoplasmalogen aldehydohydrolase
Reaction(IUBMB)
(1) 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine [RN:R02745];
(2) 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine [RN:R03415]
Reaction(KEGG)
Substrate
1-(1-alkenyl)-sn-glycero-3-phosphocholine [CPD:C04517];
H2O [CPD:C00001];
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine [CPD:C04635]
Product
aldehyde [CPD:C00071];
sn-glycero-3-phosphocholine [CPD:C00670];
sn-glycero-3-phosphoethanolamine [CPD:C01233]
Comment
Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine.
History
EC 3.3.2.2 created 1972, modified 1976, (EC 3.3.2.5 created 1984, incorporated 2016), modified 2016
Pathway
Ether lipid metabolism
Orthology
K18575  
alkenylglycerophosphocholine hydrolase
Genes
HSA: 
255043(TMEM86B)
PTR: 
456297(TMEM86B)
PPS: 
100985350(TMEM86B)
GGO: 
101134478(TMEM86B)
PON: 
100448045(TMEM86B)
NLE: 
100597527(TMEM86B)
MCC: 
699222(TMEM86B)
MCF: 
102126102(TMEM86B)
CSAB: 
103235296(TMEM86B)
RRO: 
104674761(TMEM86B)
RBB: 
108542528(TMEM86B)
CJC: 
100388681(TMEM86B)
SBQ: 
101047356(TMEM86B)
MMU: 
68255(Tmem86b)
RNO: 
690610(Tmem86b)
CGE: 
100771800(Tmem86b)
NGI: 
103744859(Tmem86b)
HGL: 
101720540(Tmem86b)
CCAN: 
109696265(Tmem86b)
OCU: 
100354255(TMEM86B)
TUP: 
102498612(TMEM86B)
CFA: 
611345(TMEM86B)
AML: 
100477670(TMEM86B)
UMR: 
103680265(TMEM86B)
FCA: 
101092067(TMEM86B)
PTG: 
102961296(TMEM86B)
AJU: 
106980918(TMEM86B)
BTA: 
518466(TMEM86B)
BOM: 
102265175(TMEM86B)
BIU: 
109571855(TMEM86B)
PHD: 
102333259(TMEM86B)
CHX: 
102186626(TMEM86B)
OAS: 
101121701(TMEM86B)
SSC: 
100514582(TMEM86B)
CFR: 
102512804(TMEM86B)
CDK: 
105098739(TMEM86B)
BACU: 
103006787(TMEM86B)
LVE: 
103082812(TMEM86B)
ECB: 
100055488(TMEM86B)
EPZ: 
103562865(TMEM86B)
EAI: 
106840930(TMEM86B)
MYB: 
MYD: 
102757075(TMEM86B)
HAI: 
109373772(TMEM86B)
RSS: 
109434207(TMEM86B)
PALE: 
102878082(TMEM86B)
LAV: 
100671261(TMEM86B)
MDO: 
103100945(TMEM86B)
OAA: 
100076472(TMEM86B)
ASN: 
102387730(TMEM86B)
AMJ: 
102558009(TMEM86B)
CPIC: 
ACS: 
DRE: 
751651(tmem86b)
IPU: 
108256452(TMEM86B)
TNG: 
NCC: 
MZE: 
101486306(tmem86b)
OLA: 
XMA: 
CSEM: 
SASA: 
ELS: 
SFM: 
DPL: 
 » show all
Taxonomy
Reference
1  [PMID:13783189]
  Authors
WARNER HR, LANDS WE.
  Title
The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether.
  Journal
J. Biol. Chem. 236 (1961) 2404-9.
Reference
2  [PMID:17805898]
  Authors
Ellingson JS, Lands WE
  Title
Phospholipid reactivation of plasmalogen metabolism.
  Journal
Lipids. 3 (1968) 111-20.
Reference
3  [PMID:7239443]
  Authors
Gunawan J, Debuch H.
  Title
Liberation of free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) by rat liver microsomes.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 362 (1981) 445-52.
Reference
4  [PMID:3753461]
  Authors
Arthur G, Page L, Mock T, Choy PC.
  Title
The catabolism of plasmenylcholine in the guinea pig heart.
  Journal
Biochem. J. 236 (1986) 475-80.
Reference
5  [PMID:21515882]
  Authors
Wu LC, Pfeiffer DR, Calhoon EA, Madiai F, Marcucci G, Liu S, Jurkowitz MS
  Title
Purification, identification, and cloning of lysoplasmalogenase, the enzyme that  catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.
  Journal
J. Biol. Chem. 286 (2011) 24916-30.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37288-65-6

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