hepoxilin-epoxide hydrolase;
hepoxilin epoxide hydrolase;
hepoxylin hydrolase;
hepoxilin A3 hydrolase

Hydrolases;
Acting on ether bonds;
Ether hydrolases

(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase

hepoxilin A3 + H2O = trioxilin A3 [RN:R04609]

R04609;
(other) R07036

hepoxilin A3 [CPD:C04849];
H2O [CPD:C00001]

Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].

1  [PMID:3348791]

Pace-Asciak CR.

Formation and metabolism of hepoxilin A3 by the rat brain.

Biochem. Biophys. Res. Commun. 151 (1988) 493-8.

Rattus norvegicus [GN:rno]

2  [PMID:2722835]

Pace-Asciak CR, Lee WS.

Purification of hepoxilin epoxide hydrolase from rat liver.

J. Biol. Chem. 264 (1989) 9310-3.

Rattus norvegicus [GN:rno]

3  [PMID:11154734]

Fretland AJ, Omiecinski CJ.

Epoxide hydrolases: biochemistry and molecular biology.

Chem. Biol. Interact. 129 (2000) 41-59.

Rattus norvegicus [GN:rno]

4  [PMID:15748653]

Newman JW, Morisseau C, Hammock BD.

Epoxide hydrolases: their roles and interactions with lipid metabolism.

Prog. Lipid. Res. 44 (2005) 1-51.

Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno], Balanus amphitrite, Elminius modestus