KEGG   ENZYME: 3.4.11.15Help
Entry
EC 3.4.11.15                Enzyme                                 

Name
aminopeptidase Y;
aminopeptidase Co;
aminopeptidase (cobalt-activated);
lysyl aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferentially, release of N-terminal lysine
Comment
Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28
History
EC 3.4.11.15 created 1989, modified 1997
Orthology
K01264  
aminopeptidase Y
Genes
SCE: 
YBR286W(APE3)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B07580(NCAS0B07580)
NDI: 
NDAI_0B04920(NDAI0B04920)
TPF: 
TPHA_0I01120(TPHA0I01120)
TBL: 
TBLA_0C02710(TBLA0C02710)
TDL: 
TDEL_0D01650(TDEL0D01650)
KAF: 
KAFR_0A03620(KAFR0A03620)
PPA: 
DHA: 
PIC: 
PICST_89245(APE3.1)
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
PAN: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_188194(AO090012000110)
ANG: 
ANI_1_196034(An03g01660)
AFV: 
ACT: 
NFI: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
PSQ: 
SRO: 
 » show all
Taxonomy
Reference
1  [PMID:6758786]
  Authors
Achstetter T, Ehmann C, Wolf DH.
  Title
Aminopeptidase Co, a new yeast peptidase.
  Journal
Biochem. Biophys. Res. Commun. 109 (1982) 341-7.
Reference
2  [PMID:8175799]
  Authors
Yasuhara T, Nakai T, Ohashi A.
  Title
Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B.
  Journal
J. Biol. Chem. 269 (1994) 13644-50.
  Sequence
[sce:YBR286W]
Reference
3  [PMID:8175800]
  Authors
Nishizawa M, Yasuhara T, Nakai T, Fujiki Y, Ohashi A.
  Title
Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase.
  Journal
J. Biol. Chem. 269 (1994) 13651-5.
  Sequence
[sce:YBR286W]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
114796-97-3

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