KEGG   ENZYME: 3.4.11.22Help
Entry
EC 3.4.11.22                Enzyme                                 

Name
aminopeptidase I;
aminopeptidase III;
aminopeptidase yscI;
leucine aminopeptidase IV;
yeast aminopeptidase I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Comment
A 640-kDa, dodecameric enzyme best known as the major vacuolar aminopeptidase of yeast, Saccharomyces cervisiae, in which species it was first given the name aminopeptidase I (one), amongst others. Activity is stimulated by both Zn2+ and Cl- ions. Type example of peptidase family M18
History
EC 3.4.11.22 created 1997
Orthology
K01268  
aminopeptidase I
Genes
SCE: 
YKL103C(APE1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A05740(NCAS0A05740)
NDI: 
NDAI_0K02710(NDAI0K02710)
TPF: 
TPHA_0G03190(TPHA0G03190)
TBL: 
TBLA_0I01160(TBLA0I01160)
TDL: 
TDEL_0A02540(TDEL0A02540)
KAF: 
KAFR_0D03190(KAFR0D03190)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT75349(NEUTE1DRAFT_75349)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1000134(AO090102000599)
ANG: 
ANI_1_802084(An09g06250)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
SHS: 
 » show all
Taxonomy
Reference
1
  Authors
Johnson, M.J.
  Title
Isolation and properties of a pure yeast polypeptidase.
  Journal
J. Biol. Chem. 137 (1941) 575-586.
Reference
2  [PMID:5147]
  Authors
Metz G, Rohm KH.
  Title
Yeast aminopeptidase I. Chemical composition and catalytic properties.
  Journal
Biochim. Biophys. Acta. 429 (1976) 933-49.
Reference
3  [PMID:2651436]
  Authors
Chang YH, Smith JA.
  Title
Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.
  Journal
J. Biol. Chem. 264 (1989) 6979-83.
  Sequence
[sce:YKL103C]
Reference
4  [PMID:8601598]
  Authors
Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ.
  Title
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
  Journal
J. Cell. Biol. 132 (1996) 999-1010.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-94-1

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