KEGG   ENZYME: 3.4.11.24Help
Entry
EC 3.4.11.24                Enzyme                                 

Name
aminopeptidase S;
Mername-AA022 peptidase;
SGAP;
aminopeptidase (Streptomyces griseus);
Streptomyces griseus aminopeptidase;
S. griseus AP;
double-zinc aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues
Comment
Aminopeptidases are associated with many biological functions, including protein maturation, protein degradation, cell-cycle control and hormone-level regulation [3,4]. This enzyme contains two zinc molecules in its active site and is activated by Ca2+ [4]. In the presence of Ca2+, the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe [3]. Peptides with proline in the P1' position are not substrates [3]. Belongs in peptidase family M28.
History
EC 3.4.11.24 created 2008
Orthology
K19702  
aminopeptidase S
Genes
LAB: 
AEI: 
SCO: 
SCO4589(SCD20.07c)
SMA: 
SAV_4872(lap1)
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SALB: 
SALS: 
STRP: 
SFI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SLD: 
SXI: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
STRF: 
LMOI: 
KFL: 
SRO: 
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
ALU: 
PSEA: 
PSEE: 
PSEQ: 
PECQ: 
AMI: 
SESP: 
BN6_58410(lieA)
KPHY: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
AMS: 
AFS: 
SNA: 
ELB: 
 » show all
Taxonomy
Reference
1  [PMID:2503378]
  Authors
Spungin A, Blumberg S.
  Title
Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme.
  Journal
Eur. J. Biochem. 183 (1989) 471-7.
  Sequence
[sgr:SGR_5809]
Reference
2  [PMID:8444149]
  Authors
Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S.
  Title
Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution.
  Journal
Eur. J. Biochem. 212 (1993) 107-12.
  Sequence
[sgr:SGR_5809]
Reference
3  [PMID:16080009]
  Authors
Arima J, Uesugi Y, Iwabuchi M, Hatanaka T.
  Title
Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica.
  Journal
Appl. Microbiol. Biotechnol. 70 (2006) 541-7.
Reference
4  [PMID:15280041]
  Authors
Fundoiano-Hershcovitz Y, Rabinovitch L, Langut Y, Reiland V, Shoham G, Shoham Y.
  Title
Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus.
  Journal
FEBS. Lett. 571 (2004) 192-6.
Reference
5  [PMID:10771423]
  Authors
Gilboa R, Greenblatt HM, Perach M, Spungin-Bialik A, Lessel U, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G.
  Title
Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 56 (2000) 551-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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