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Entry
EC 3.4.11.26                Enzyme                                 

Name
intermediate cleaving peptidase 55;
Icp55;
mitochondrial intermediate cleaving peptidase 55 kDa
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Comment
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.
History
EC 3.4.11.26 created 2011
Orthology
K18573  
intermediate cleaving peptidase 55
Genes
CRE: 
BPG: 
SCE: 
YER078C(ICP55)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E03450(NCAS0E03450)
NDI: 
NDAI_0A03130(NDAI0A03130)
TPF: 
TPHA_0P00720(TPHA0P00720)
TBL: 
TBLA_0F01960(TBLA0F01960)
TDL: 
TDEL_0H01760(TDEL0H01760)
KAF: 
KAFR_0L01090(KAFR0L01090)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT124894(NEUTE1DRAFT_124894)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1070164(AO090001000597)
ANG: 
ANI_1_928094(An11g06960)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT64099(AGABI1DRAFT_64099)
ABV: 
AGABI2DRAFT219147(AGABI2DRAFT_219147)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
PGR: 
MLR: 
 » show all
Taxonomy
Reference
1  [PMID:19720832]
  Authors
Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O
  Title
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.
  Journal
J. Biol. Chem. 284 (2009) 30200-8.
  Sequence
[sce:YER078C]
Reference
2  [PMID:19837041]
  Authors
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
  Title
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
  Journal
Cell. 139 (2009) 428-39.
  Sequence
[sce:YER078C]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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