KEGG   ENZYME: 3.4.11.3Help
Entry
EC 3.4.11.3                 Enzyme                                 
Name
cystinyl aminopeptidase;
cystyl-aminopeptidase;
oxytocinase;
cystine aminopeptidase;
L-cystine aminopeptidase;
oxytocin peptidase;
vasopresssinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4]
Comment
A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family)
Orthology
K01257  
cystinyl aminopeptidase
Genes
HSA: 
4012(LNPEP)
PTR: 
461960(LNPEP)
PPS: 
100975663(LNPEP)
GGO: 
PON: 
100439455(LNPEP)
MCC: 
703949(LNPEP)
MMU: 
240028(Lnpep)
RNO: 
CFA: 
488896(LNPEP)
AML: 
100473699(LNPEP)
FCA: 
101083321(LNPEP)
BTA: 
521633(LNPEP)
SSC: 
100125826(LNPEP)
ECB: 
100073222(LNPEP)
MDO: 
100015080(LNPEP)
SHR: 
100925233(LNPEP)
OAA: 
100081694(LNPEP)
GGA: 
427279(LNPEP)
TGU: 
100218959
ACS: 
100565555(lnpep)
XLA: 
495293(lnpep)
XTR: 
100216271(lnpep)
DRE: 
322814(lnpep)
TRU: 
101075332
OLA: 
101154957
 » show all
Taxonomy
Reference
1  [PMID:6041057]
  Authors
Sjoholm I.
  Title
Biochemical studies on oxytocin and oxytocinase.
  Journal
Acta. Pharm. Suec. 4 (1967) 81-96.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:4292447]
  Authors
Sjoholm I, Yman L.
  Title
Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin-II-amide by oxytocinase (cystine aminopeptidase).
  Journal
Acta. Pharm. Suec. 4 (1967) 65-76.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:5421622]
  Authors
Yman L.
  Title
Studies on human serum aminopeptidases. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum.
  Journal
Acta. Pharm. Suec. 7 (1970) 75-86.
  Organism
Homo sapiens [GN:hsa]
Reference
4
  Authors
Sakura, H., Lin, T.Y., Doi, M., Mizutani, S. and Kawashima, Y.
  Title
Purification and properties of oxytocinase, a metalloenzyme.
  Journal
Biochem. Int. 2 (1981) 173-179.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-41-8
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