KEGG   ENZYME: 3.4.14.11Help
Entry
EC 3.4.14.11                Enzyme                                 

Name
Xaa-Pro dipeptidyl-peptidase;
X-prolyl dipeptidyl aminopeptidase;
PepX;
X-prolyl dipeptidyl peptidase;
X-Pro dipeptidyl-peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolyses Xaa-Pro! bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro!p-nitroanilide and (sequentially) Tyr-Pro!Phe-Pro!Gly-Pro!Ile
Comment
The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15. The reaction is similar to that catalysed by dipeptidyl-peptidase IV of animals
History
EC 3.4.14.11 created 1996
Orthology
K01281  X-Pro dipeptidyl-peptidase
Genes
BML: BMA10229_0065
BMN: BMA10247_A1555
BMAL: DM55_4379
BMAQ: DM76_3329
BMAZ: BM44_4592
BMAB: BM45_3715
BPS: BPSS0654 BPSS1992
BPM: BURPS1710b_A1100(pepX) BURPS1710b_A2222(pepX)
BPL: BURPS1106A_A0882 BURPS1106A_A2707
BPD: BURPS668_A0974 BURPS668_A2859
BTQ: BTQ_3672
BTJ: BTJ_4705
BTZ: BTL_5492
BTD: BTI_5001
BTV: BTHA_4711
BTHE: BTN_5162
BTHM: BTRA_5431
BTHA: DR62_5292
BTHL: BG87_5504
BOK: DM82_6286
BOC: BG90_4382
BVE: AK36_3312
BCN: Bcen_3229
BCJ: BCAM2378(pepX)
BCEW: DM40_3043
BCEO: I35_6274(pepX)
BAM: Bamb_4532
BCT: GEM_3317
BCED: DM42_5610
BDL: AK34_3439
BCON: NL30_00570
BUB: BW23_4844
BLAT: WK25_27790
BTEI: WS51_08865
BSEM: WJ12_31825
BMEC: WJ16_30270
BSTG: WT74_18225
BUK: MYA_3073
BUL: BW21_4530
BAN: BA_2860
BAR: GBAA_2860
BAT: BAS2667
BAI: BAA_2920
BANT: A16_28910
BANR: A16R_29340
BANS: BAPAT_2748
BANV: DJ46_1632
BCE: BC2861
BCA: BCE_2891
BCZ: BCE33L2588(pepX)
BCQ: BCQ_2696(pepX)
BCX: BCA_2940
BAL: BACI_c28250(pepX)
BNC: BCN_2719
BCF: bcf_13990
BCER: BCK_20570
BTK: BT9727_2618(pepX)
BTL: BALH_2564
BTT: HD73_3118
BTHI: BTK_15470
BTM: MC28_2048
BTI: BTG_05045
BTW: BF38_4025
BWW: bwei_2167(pepX)
BMYC: DJ92_5327
BMYO: BG05_3161
LLA: L118079(pepXP)
LLK: LLKF_2295(pepX)
LLT: CVCAS_2036(pepXP)
LLS: lilo_2038(pepXP)
LLX: NCDO2118_2157(pepX)
LLC: LACR_2342
LLM: llmg_2328(pepXP)
LLR: llh_11915
LLI: uc509_2025(pepXP)
LLW: kw2_2106
LLJ: LG36_2000(pepX)
LGR: LCGT_0197
LGV: LCGL_0197
SPY: SPy_1858(pepXP)
SPZ: M5005_Spy1577(pepXP)
SPYM: M1GAS476_1657(pepXP)
SPG: SpyM3_1603(pepXP)
SPS: SPs0264
SPH: MGAS10270_Spy1644(pepXP)
SPI: MGAS10750_Spy1635(pepXP)
SPJ: MGAS2096_Spy1602(pepXP)
SPK: MGAS9429_Spy1582(pepXP)
SPF: SpyM50273(pepXP)
SPB: M28_Spy1565(pepXP)
STG: MGAS15252_1420(pepXP)
SOZ: Spy49_1451(pepXP)
STZ: SPYALAB49_001567(pepX)
STX: MGAS1882_1481(pepXP)
SPYA: A20_1624(pepX)
SPYH: L897_07900
SPN: SP_0894(pepX)
SPD: SPD_0787(pepX)
SPR: spr0794(pepXP)
SPW: SPCG_0870
SPX: SPG_0820
SNE: SPN23F08160(pepXP)
SPV: SPH_1001
SJJ: SPJ_0835
SPP: SPP_0902
SNT: SPT_1305
SNC: HMPREF0837_11596(pepX)
SNP: SPAP_0923
SNI: INV104_07620(pepXP)
SNV: SPNINV200_08180(pepXP)
SNX: SPNOXC08020(pepXP)
SND: MYY_1303
SNU: SPNA45_01197(pepXP)
SPNE: SPN034156_18500(pepXP)
SPNU: SPN034183_08020(pepXP)
SPNM: SPN994038_07910(pepXP)
SPNO: SPN994039_07920(pepXP)
SPNN: T308_06130
SAG: SAG1736(pepX)
SAN: gbs1781
SAK: SAK_1744(pepX)
SGC: A964_1641(pepXP)
SAGL: GBS222_1457(pepX)
SAGM: BSA_17910
SAGI: MSA_18590
SAGR: SAIL_17950
SAGP: V193_07770
SAGC: DN94_07770
SAGE: EN72_09340
SAGG: EN73_08515
SAGN: W903_1725(pepX)
SMU: SMU_395(pepX)
SMC: SmuNN2025_1563(pepX)
SMJ: SMULJ23_1582(pepX)
SMUA: SMUFR_0338(pepXP)
STC: str1672(pepXP)
STL: stu1672(pepXP)
STE: STER_1633
STN: STND_1607
STU: STH8232_1920(pepX)
STW: Y1U_C1564
STHE: T303_09180
SSA: SSA_0328(pepXP)
SSB: SSUBM407_0181(pepXP)
SSI: SSU0187(pepXP)
SSS: SSUSC84_0179(pepXP)
SST: SSUST3_0201(pepXP)
SSK: SSUD12_0182(pepXP)
SUP: YYK_00850
SSUT: TL13_0237
SSUI: T15_0179(pepXP)
SSUY: YB51_0950
SGO: SGO_0234(pepX) SGO_1415
SEZ: Sez_0319(pepX)
SEQ: SZO_16580
SEZO: SeseC_00368(pepXP)
SEQU: Q426_07705
SEU: SEQ_0383
SUB: SUB1574(pepXP)
SDS: SDEG_1909(pepX)
SDA: GGS_1726(pepX)
SDC: SDSE_1994(pepX)
SDQ: SDSE167_1968(pepX)
SGG: SGGBAA2069_c19090(pepX)
SGT: SGGB_1942(pepXP)
SMB: smi_1001(pepX)
SOR: SOR_1151(pepX)
STK: STP_0130
STB: SGPB_1791(pepXP)
SSR: SALIVB_1785(pepX)
STF: Ssal_00364(pepXP)
STJ: SALIVA_1735(pepX)
SSAH: HSISS4_01580(pepXP)
SMN: SMA_1862(pepX)
SIF: Sinf_1676(pepX)
SIE: SCIM_0175(pepXP)
SIB: SIR_0234(pepX)
SIU: SII_0220(pepX)
SANG: SAIN_0159(pepX)
SANC: SANR_0181(pepX)
SANS: DK43_09325
SCG: SCI_0237(pepX)
SCON: SCRE_0217(pepX)
SCOS: SCR2_0217(pepX)
SIK: K710_1842
SLU: KE3_1794
LPL: lp_0857(pepX)
LPJ: JDM1_0714(pepX)
LPT: zj316_0905(pepX)
LPS: LPST_C0671(pepX)
LPZ: Lp16_0681
LJO: LJ_1585
LJF: FI9785_681(pepX)
LJH: LJP_0636c
LAC: LBA1373(pepX)
LAD: LA14_1371
LAF: SD55_1357(pepX)
LSA: LCA_0643(pepX)
LSL: LSL_1534
LSI: HN6_01285(pepX)
LSJ: LSJ_1584
LDB: Ldb1455(pepX)
LBU: LBUL_1351
LDL: LBU_1250
LBR: LVIS_1782
LCA: LSEI_1651
LPAP: LBPC_1573
LCB: LCABL_18670(pepX)
LCS: LCBD_1852
LCE: LC2W_1825
LCW: BN194_18330(pepX)
LGA: LGAS_0712
LRE: Lreu_1647
LRF: LAR_1538
LRT: LRI_0341
LHE: lhv_1436
LHL: LBHH_0732
LHV: lhe_1355(pepX)
LHH: LBH_1191
LHD: HUO_04900
LFE: LAF_1668
LFR: LC40_1057
LFF: LBFF_1848
LRH: LGG_01695(pepX)
LRG: LRHM_1631
LRL: LC705_01679(pepX)
LRA: LRHK_1667(pepX)
LCR: LCRIS_01364(pepXP)
LAM: LA2_07925
LBN: LBUCD034_0447(pepx1) LBUCD034_1936(pepx3)
LKE: WANG_0360
LRM: LRC_01770(pepX)
LSN: LSA_11480(pepX)
LAE: LBAT_0602
PPE: PEPE_0380
PPEN: T256_01990
PCE: PECL_1458(pepX)
OOE: OEOE_1411
LME: LEUM_0506
LMM: MI1_02245
LMK: LMES_0438
LKI: LKI_02815
LGS: LEGAS_1361(pepX)
SCT: SCAT_5096
SBH: SBI_02636
SHY: SHJG_7632
SVE: SVEN_6420
SALU: DC74_6757
SALL: SAZ_35090
STRE: GZL_02009
SLD: T261_1231
SRW: TUE45_07280(pepX)
SLE: sle_10830(sle_10830)
SALJ: SMD11_1124
SRO: Sros_3908
SEN: SACE_1771(pepX) SACE_6505
AMD: AMED_2407(pepX) AMED_6004(pepX) AMED_6355(pepX)
AMM: AMES_2380(pepX) AMES_5919(pepX) AMES_6264(pepX)
AMZ: B737_2381(pepX) B737_5919(pepX) B737_6264(pepX)
AOI: AORI_2204(pepX) AORI_2376(pepX) AORI_5025(pepX)
AMI: Amir_1460
AHG: AHOG_05850(pepX1) AHOG_08170(pepX2) AHOG_24805(pepX3)
RBA: RB9674(pepX)
PIR: VN12_20175(pepX)
FMR: Fuma_06216(pepX)
GAU: GAU_1045
DORI: FH5T_07095
ZPR: ZPR_2073
WIN: WPG_3486
AALG: AREALGSMS7_03937(pepX)
NMG: Nmag_1938
 » show all
Taxonomy
Reference
1
  Authors
Zevaco, C., Monnet, V. and Gripon, J.-C.
  Title
Intracellular X-prolyl dipeptidyl peptidase from Lactococcus lactis spp. lactis: purification and properties.
  Journal
J. Appl. Bacteriol. 68 (1990) 357-366.
Reference
2  [PMID:7765315]
  Authors
Meyer-Barton EC, Klein JR, Imam M, Plapp R.
  Title
Cloning and sequence analysis of the X-prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbruckii ssp. lactis DSM7290.
  Journal
Appl. Microbiol. Biotechnol. 40 (1993) 82-9.
  Sequence
Reference
3  [PMID:7765768]
  Authors
Habibi-Najafi MB, Lee BH.
  Title
Purification and characterization of X-prolyl dipeptidyl peptidase from Lactobacillus casei subsp. casei LLG.
  Journal
Appl. Microbiol. Biotechnol. 42 (1994) 280-6.
Reference
4  [PMID:7710078]
  Authors
Chich JF, Gripon JC, Ribadeau-Dumas B.
  Title
Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents.
  Journal
Anal. Biochem. 224 (1995) 245-9.
Reference
5
  Authors
Chich, J.-F., Chapot-Chartier, M.P., Ribadeau-Dumas, B. and Gripon, J.-C.
  Title
Identification of the active site serine of the X-prolyl aminopeptidase from Lactococcus lactis.
  Journal
FEBS Lett. 314 (1995) 139-142.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.11
IUBMB Enzyme Nomenclature: 3.4.14.11
ExPASy - ENZYME nomenclature database: 3.4.14.11
BRENDA, the Enzyme Database: 3.4.14.11
CAS: 54249-88-6

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