KEGG   ENZYME: 3.4.14.5Help
Entry
EC 3.4.14.5                 Enzyme                                 
Name
dipeptidyl-peptidase IV;
dipeptidyl aminopeptidase IV;
Xaa-Pro-dipeptidyl-aminopeptidase;
Gly-Pro naphthylamidase;
postproline dipeptidyl aminopeptidase IV;
lymphocyte antigen CD26;
glycoprotein GP110;
dipeptidyl peptidase IV;
glycylproline aminopeptidase;
glycylproline aminopeptidase;
X-prolyl dipeptidyl aminopeptidase;
pep X;
leukocyte antigen CD26;
glycylprolyl dipeptidylaminopeptidase;
dipeptidyl-peptide hydrolase;
glycylprolyl aminopeptidase;
dipeptidyl-aminopeptidase IV;
DPP IV/CD26;
amino acyl-prolyl dipeptidyl aminopeptidase;
T cell triggering molecule Tp103;
X-PDAP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
Comment
A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase of lactococci
Orthology
K01278  
dipeptidyl-peptidase 4
K08655  
dipeptidyl-peptidase 8
K08656  
dipeptidyl-peptidase 9
Genes
HSA: 
1803(DPP4) 54878(DPP8) 91039(DPP9)
PTR: 
100608569(DPP9) 453518(DPP8) 459689(DPP4)
PPS: 
100972720(DPP9) 100982048(DPP8) 100983437(DPP4)
GGO: 
101127346(DPP8) 101140329(DPP4) 101142264(DPP9)
PON: 
100173322(DPP4) 100437219(DPP8) 100453903(DPP9)
MCC: 
654491(DPP4) 695587 709428(DPP8)
MMU: 
13482(Dpp4) 224897(Dpp9) 74388(Dpp8)
RNO: 
25253(Dpp4) 301130(Dpp9) 315758(Dpp8)
CFA: 
478767(DPP4) 485033(DPP9) 487605(DPP8)
AML: 
FCA: 
101084543(DPP8) 101091347(DPP9) 493787(DPP4)
BTA: 
281122(DPP4) 521100(DPP9) 536604(DPP8)
SSC: 
100155833(DPP8) 397492(DPP4)
ECB: 
100053245(DPP8) 100061124(DPP4) 100062517(DPP9)
MDO: 
100022348(DPP4) 100023447(DPP9) 100024489
SHR: 
100914547(DPP4) 100918836(DPP8) 100919219(DPP9)
OAA: 
100075193(DPP8) 100082186
GGA: 
420159(DPP9) 424187(DPP4) 427512(DPP8)
MGP: 
100541733(DPP9) 100545223(DPP8) 100547424
TGU: 
100225275(DPP9) 100225430 100231365(DPP4)
ACS: 
100554124 100554319(dpp8)
XLA: 
100190777(dpp8-a) 397888(dpp4) 443772(dpp9)
XTR: 
100124922(dpp8) 548987(dpp4) 779598(dpp9)
DRE: 
100301982(dpp4) 565888(fap) 768170(dpp9)
TRU: 
101070513 101075706 101077015
OLA: 
101163029 101166610
BFO: 
BRAFLDRAFT_66877 BRAFLDRAFT_92908
CIN: 
100178732 100180483
SPU: 
576891(DPP9)
DME: 
Dmel_CG11034 Dmel_CG3744
DPO: 
Dpse_GA10719 Dpse_GA16711 Dpse_GA17656
DAN: 
Dana_GF15583 Dana_GF18681 Dana_GF24616
DER: 
Dere_GG12305 Dere_GG15695 Dere_GG25098
DPE: 
Dper_GL19035 Dper_GL22341
DSE: 
Dsec_GM18574 Dsec_GM23448 Dsec_GM25479
DSI: 
Dsim_GD14501 Dsim_GD18255 Dsim_GD23364
DWI: 
Dwil_GK14029 Dwil_GK14030 Dwil_GK14699
DYA: 
Dyak_GE10760 Dyak_GE25657
DGR: 
Dgri_GH10923 Dgri_GH14757 Dgri_GH15202
DMO: 
Dmoj_GI13357 Dmoj_GI22496
DVI: 
Dvir_GJ10097 Dvir_GJ11997 Dvir_GJ13694
AGA: 
AgaP_AGAP003138 AgaP_AGAP008176
AAG: 
AaeL_AAEL008373 AaeL_AAEL015110 AaeL_AAEL015386
CQU: 
CpipJ_CPIJ005491 CpipJ_CPIJ011776
AME: 
410337 411229 412681
NVI: 
100114441(NV18472) 100120008(NV13768) 100123733(NV10827)
TCA: 
660643 660714 663932
API: 
100165654 100166342
PHU: 
Phum_PHUM073920 Phum_PHUM451260 Phum_PHUM452830
ISC: 
IscW_ISCW003960
CEL: 
CELE_K02F2.1(dpf-3)
BMY: 
Bm1_48250 Bm1_55365
SMM: 
Smp_127840
NVE: 
NEMVE_v1g161332
TAD: 
TRIADDRAFT_24254 TRIADDRAFT_64278
AQU: 
100632393
ATH: 
AT5G24260
ALY: 
ARALYDRAFT_910452
GMX: 
100777293 100812178
MTR: 
MTR_3g091420
CSV: 
101223131 101228699
RCU: 
RCOM_1243220
POP: 
POPTR_661521 POPTR_824531
VVI: 
100241749
OSA: 
4329059
DOSA: 
Os02t0290600-01(Os02g0290600)
BDI: 
100822560
SBI: 
SORBI_04g011310(SORBIDRAFT_04g011310)
ZMA: 
100381646(pco064771(293))
SMO: 
SELMODRAFT_126802
PPP: 
PHYPADRAFT_104540 PHYPADRAFT_105959
PAN: 
PODANSg562
MTM: 
MYCTH_80274
MGR: 
MGG_05989
FGR: 
FG10982.1
NHE: 
NECHADRAFT_93193
VAL: 
VDBG_07675
ANI: 
AN6438.2
NFI: 
NFIA_106690
AFM: 
AFUA_4G09320
AOR: 
AOR_1_1034144(AO090023000602)
AFV: 
AFLA_110160
ACT: 
ACLA_048680
CIM: 
CIMG_04442
CPW: 
CPC735_073130
PBL: 
PAAG_06844
URE: 
UREG_01669
ABE: 
ARB_06110
TVE: 
TRV_00096
AJE: 
HCAG_04449
PNO: 
SNOG_08864
PTE: 
PTT_16074
ZTR: 
MYCGRDRAFT_43499
TML: 
GSTUM_00000118001
DDI: 
DDB_G0281415
DPP: 
DICPUDRAFT_57365
PTI: 
PHATRDRAFT_24120
TPS: 
THAPSDRAFT_34973
PIF: 
PITG_10932
XCC: 
XCC3961
XCB: 
XC_4051
XCA: 
xccb100_4151
XCV: 
XCV4136
XCP: 
XCR_0311
XAC: 
XAC4046
XAX: 
XACM_3913
XAO: 
XAC29_20380
XOO: 
XOO0398
XOM: 
XOO_0361
XOP: 
PXO_02809
XOR: 
XOC_4115
XAL: 
XALc_3000
XCI: 
XCAW_00256(dAP2)
SML: 
Smlt4503
SMT: 
Smal_3865
BUJ: 
BurJV3_3912
SMZ: 
SMD_4050
PSU: 
Psesu_2827
PSD: 
DSC_01830
FAU: 
Fraau_3221
SON: 
SO_3990(dpp4)
SDN: 
Sden_2985
SFR: 
Sfri_0532
SAZ: 
Sama_0600
SBL: 
Sbal_0785
SBM: 
Shew185_3720
SBN: 
Sbal195_3843
SBP: 
Sbal223_3662
SBT: 
Sbal678_3874
SBS: 
Sbal117_0709
SBB: 
Sbal175_3642
SLO: 
Shew_0774
SPC: 
Sputcn32_0677
SHP: 
Sput200_0609
SSE: 
Ssed_0814
SPL: 
Spea_0732
SHE: 
Shewmr4_0650
SHM: 
Shewmr7_3372
SHN: 
Shewana3_0649
SHW: 
Sputw3181_3494
SHL: 
Shal_0785
SWD: 
Swoo_3769
SWP: 
swp_4348
SVO: 
SVI_3599
ILO: 
IL1027 IL2328
CPS: 
CPS_1104
PHA: 
PSHAa2386 PSHAb0005
PAT: 
Patl_3968
PSM: 
PSM_A0689 PSM_B0009
AMAC: 
MASE_16020
AMB: 
AMBAS45_16600
AMG: 
AMEC673_16315
AMK: 
AMBLS11_15775
AMAA: 
amad1_17185
ALT: 
ambt_00550
GAG: 
Glaag_0323
GNI: 
GNIT_0783(dpp4) GNIT_1405
GPS: 
C427_4831
FBL: 
Fbal_3120
KKO: 
Kkor_0716
SAGA: 
M5M_06420
GUR: 
Gura_1624
ADE: 
Adeh_1335
ACP: 
A2cp1_2619
AFW: 
Anae109_2431
ANK: 
AnaeK_2523
MXA: 
MXAN_0515(dpp4) MXAN_1682 MXAN_6038
MFU: 
LILAB_16100
MSD: 
MYSTI_06665 MYSTI_07866
CCX: 
COCOR_06572(ptpA1) COCOR_06573(ptpA2)
SUR: 
STAUR_5998 STAUR_6715
SCL: 
sce4363
HOH: 
Hoch_4258
CCR: 
CC_2154
CCS: 
CCNA_02237
CAK: 
Caul_3418
CSE: 
Cseg_1267
PZU: 
PHZ_c2627
BSB: 
Bresu_2458
AEX: 
Astex_2740
MMR: 
Mmar10_2106
HNE: 
HNE_1217
HBA: 
Hbal_0359
ZMO: 
ZMO1408
ZMN: 
Za10_1779
ZMM: 
Zmob_1699
ZMB: 
ZZ6_1672
ZMP: 
Zymop_1658
NAR: 
Saro_1409
SPHM: 
G432_00900
SJP: 
SJA_C1-16910(dpp4)
SCH: 
Sphch_0741
ELI: 
ELI_07440
GOX: 
GOX1461
GOH: 
B932_1719
GDI: 
GDI_0823
GDJ: 
Gdia_1194
RCE: 
RC1_1181
PBR: 
PB2503_12059
SAY: 
TPY_3390
SAP: 
Sulac_1524
SCO: 
SCO5122(SC9E12.07c)
SMA: 
SAV_3144
SGR: 
SGR_2407
SCB: 
SCAB_31381
SSX: 
SACTE_4354
SVL: 
Strvi_1442
SCT: 
SCAT_0685 SCAT_3980
SCY: 
SCATT_06940 SCATT_39650
SFA: 
Sfla_2170
SBH: 
SBI_04103
SHY: 
SHJG_6224
SHO: 
SHJGH_5985
SVE: 
SVEN_4771
SDV: 
BN159_3282
SALB: 
XNR_1688
STRP: 
F750_4642
SFI: 
SFUL_4923
KSK: 
KSE_48350 KSE_67150
KFL: 
Kfla_5916
TFU: 
Tfu_0485
NDA: 
Ndas_3909
NAL: 
B005_1087
TCU: 
Tcur_1129
SRO: 
Sros_5287 Sros_8451
SEN: 
SACE_5227
SVI: 
Svir_23950
TBI: 
Tbis_3037
AMD: 
AMED_2687
AMN: 
RAM_13660
AMM: 
AMES_2659
PDX: 
Psed_3850
AMI: 
Amir_5657
SESP: 
BN6_67810
STP: 
Strop_3764
SAQ: 
Sare_4146
MAU: 
Micau_5324
MIL: 
ML5_2968
VMA: 
VAB18032_00310
AMS: 
AMIS_73700
ASE: 
ACPL_7650
CAI: 
Caci_0755
SNA: 
Snas_1253
BLO: 
BL0582
BLJ: 
BLD_1376(dppX1)
BLN: 
Blon_0084
BLON: 
BLIJ_0083
BLF: 
BLIF_0053
BLL: 
BLJ_0058
BLB: 
BBMN68_1311(dppX1)
BLM: 
BLLJ_0065
BLK: 
BLNIAS_02741(dppX1)
BLG: 
BIL_18920
BAD: 
BAD_0045
BLA: 
BLA_0082
BLC: 
Balac_0091
BLT: 
Balat_0091
BBB: 
BIF_01502
BBC: 
BLC1_0084
BNM: 
BALAC2494_01030
BLV: 
BalV_0089
BLW: 
W7Y_0090
BLS: 
W91_0089
BNI: 
BANAN_00470
BDE: 
BDP_0045
BBI: 
BBIF_0142
BBP: 
BBPR_0109(pepX)
BBF: 
BBB_0093
BBV: 
HMPREF9228_0072
BBRU: 
Bbr_0074(pepX)
BAST: 
BAST_0079
BTP: 
D805_0030
AFO: 
Afer_1602
AYM: 
YM304_10500
ABA: 
Acid345_0056
ACA: 
ACP_2647
ACM: 
AciX9_1664
SUS: 
Acid_5302
CTM: 
Cabther_A1882
BTH: 
BT_4193
BFR: 
BF0977
BFS: 
BF0899
BFG: 
BF638R_0084 BF638R_0958
BVU: 
BVU_1094 BVU_1991 BVU_3876
BHL: 
Bache_0782 Bache_1336
BSA: 
Bacsa_1666 Bacsa_2260
BXY: 
BXY_23820 BXY_33000
PGI: 
PG0503(dpp)
PGN: 
PGN_1149 PGN_1469(dpp)
PGT: 
PGTDC60_1620(dpp) PGTDC60_2108
PAH: 
Poras_0243 Poras_1656
PDI: 
BDI_2193 BDI_2246 BDI_3094
PPN: 
Palpr_0177
OSP: 
Odosp_0441 Odosp_0989
TFO: 
BFO_1007 BFO_1659
PRU: 
PRU_0634 PRU_1806
PMZ: 
HMPREF0659_A5571 HMPREF0659_A6751
PDN: 
HMPREF9137_1131 HMPREF9137_1238
PIT: 
PIN17_0478 PIN17_A1740
PDT: 
Prede_1703 Prede_1788
AFD: 
Alfi_0868
SRU: 
SRU_0572
SRM: 
SRM_00664
RMR: 
Rmar_0996
RMG: 
Rhom172_1870
CPI: 
Cpin_0505 Cpin_4028
NKO: 
Niako_4688 Niako_5714
PHE: 
Phep_1241 Phep_2549
PSN: 
Pedsa_3121
SHG: 
Sph21_0993 Sph21_2473
SCN: 
Solca_1379 Solca_1443 Solca_1799
HHY: 
Halhy_2918 Halhy_3444
SGN: 
SGRA_0030 SGRA_3811
CMR: 
Cycma_1643
BBD: 
Belba_1253
EVI: 
Echvi_0691 Echvi_1103
DFE: 
Dfer_3655
SLI: 
Slin_1085 Slin_6185
LBY: 
Lbys_1450 Lbys_2150
RSI: 
Runsl_4225 Runsl_4712
FLI: 
Fleli_0808 Fleli_1141
EOL: 
Emtol_0667 Emtol_0865
FAE: 
FAES_0688 FAES_2606
MTT: 
Ftrac_0819 Ftrac_1503
GFO: 
GFO_2972
FJO: 
Fjoh_1419
FPS: 
FP1112(pepX2) FP2339(pepX1)
FBR: 
FBFL15_0463(pepX1) FBFL15_0780(pepX2)
FCO: 
FCOL_01150 FCOL_04210
FIN: 
KQS_01510(pepX1) KQS_04155(pepX2)
COC: 
Coch_0754 Coch_1057
CCM: 
Ccan_05140 Ccan_17390
RBI: 
RB2501_08865
ZPR: 
ZPR_0647 ZPR_1387
CAT: 
CA2559_04800
RAN: 
Riean_0729 Riean_1719
RAI: 
RA0C_0966 RA0C_2015
RAR: 
RIA_0464 RIA_1516
RAG: 
B739_0143 B739_1146
RAE: 
G148_0889 G148_1867
FBC: 
FB2170_04105 FB2170_08459
CAO: 
Celal_0918
CLY: 
Celly_3275
WVI: 
Weevi_0787 Weevi_1156
KDI: 
Krodi_0611
LAN: 
Lacal_0571
ZGA: 
zobellia_1190(dppA1) zobellia_3547(dppA2)
MRS: 
Murru_0880
ASL: 
Aeqsu_0599 Aeqsu_1939
ORH: 
Ornrh_0745 Ornrh_1342
PTQ: 
P700755_002259 P700755_002871
NDO: 
DDD_2039
POM: 
MED152_06250(dpp)
FBA: 
FIC_01450 FIC_01798
FTE: 
Fluta_2453 Fluta_2739
OHO: 
Oweho_0556 Oweho_3014
RBA: 
RB1225(dpp4)
PLM: 
Plim_2538
IPA: 
Isop_0088 Isop_1654
SACI: 
Sinac_5996
GVI: 
gll3871
IAL: 
IALB_0193
MHU: 
Mhun_0346
 » show all
Taxonomy
Reference
1  [PMID:1352704]
  Authors
Misumi Y, Hayashi Y, Arakawa F, Ikehara Y.
  Title
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface.
  Journal
Biochim. Biophys. Acta. 1131 (1992) 333-6.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:8102366]
  Authors
David F, Bernard AM, Pierres M, Marguet D.
  Title
Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases.
  Journal
J. Biol. Chem. 268 (1993) 17247-52.
  Organism
Mus musculus [GN:mmu]
Reference
3  [PMID:7845210]
  Authors
Ikehara Y, Ogata S, Misumi Y.
  Title
Dipeptidyl-peptidase IV from rat liver.
  Journal
Methods. Enzymol. 244 (1994) 215-27.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
54249-88-6
DBGET integrated database retrieval system