KEGG   ENZYME: 3.4.14.9Help
Entry
EC 3.4.14.9                 Enzyme                                 
Name
tripeptidyl-peptidase I;
tripeptidyl aminopeptidase;
tripeptidyl peptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.
Comment
A lysosomal enzyme that is active at acidic pH. Deficient in classical late-infantile neuronal ceroid lipofuscinosis brain tissue. Belongs in peptidase family S53. Formerly included in EC 3.4.14.8.
Orthology
K01279  
tripeptidyl-peptidase I
Genes
HSA: 
1200(TPP1)
PTR: 
450999(TPP1)
PPS: 
100969179(TPP1)
GGO: 
101149790(TPP1)
PON: 
100440001(TPP1)
MCC: 
MMU: 
12751(Tpp1)
RNO: 
83534(Tpp1)
CFA: 
485337(TPP1)
AML: 
FCA: 
101093296(TPP1)
BTA: 
515575(TPP1)
SSC: 
100623352
ECB: 
100070095
MDO: 
100030970
SHR: 
100918462(TPP1)
OAA: 
100682200
GGA: 
425576(TPP1)
TGU: 
100232321(TPP1)
ACS: 
100556940
XLA: 
414505(tpp1)
XTR: 
100124868(tpp1)
DRE: 
798347(tpp1)
TRU: 
101071259
OLA: 
101174237
BFO: 
BRAFLDRAFT_118677
NVE: 
NEMVE_v1g242624
HMG: 
100213935
AQU: 
100634818
NCR: 
NCU08418 NCU10306
SMP: 
SMAC_08129
PAN: 
PODANSg587
TTT: 
THITE_159718 THITE_2107766
MTM: 
MYCTH_79026
MGR: 
MGG_00940 MGG_07404 MGG_07559
FGR: 
FG03072.1 FG10343.1
NHE: 
NECHADRAFT_40968 NECHADRAFT_56813
VAL: 
VDBG_08725
SSL: 
SS1G_04958 SS1G_07655 SS1G_09225 SS1G_09268 SS1G_13922
BFU: 
BC1G_00978 BC1G_01026 BC1G_02944 BC1G_12776
ANI: 
AN3020.2 AN7159.2
NFI: 
NFIA_029950 NFIA_068200 NFIA_102320
AFM: 
AFUA_3G08930 AFUA_4G03490 AFUA_4G14000
AOR: 
AOR_1_122124(AO090166000084) AOR_1_386054(AO090011000235)
ANG: 
ANI_1_368124(An14g02470) ANI_1_676074(An08g04640)
AFV: 
AFLA_000860 AFLA_040430 AFLA_086160
ACT: 
ACLA_036900 ACLA_052980 ACLA_055020
PCS: 
Pc12g14680 Pc20g03930
CIM: 
CIMG_00167 CIMG_02188 CIMG_03887
CPW: 
CPC735_004570 CPC735_038590 CPC735_059790
PBL: 
PAAG_00680 PAAG_03787
URE: 
UREG_00260 UREG_01816 UREG_02074
ABE: 
ARB_04101 ARB_05765
TVE: 
TRV_03885 TRV_04476
AJE: 
HCAG_04281 HCAG_04348
PNO: 
SNOG_01085 SNOG_09464 SNOG_12941 SNOG_14758
PTE: 
PTT_08432 PTT_12932 PTT_15673 PTT_18090
ZTR: 
MYCGRDRAFT_50687 MYCGRDRAFT_67015 MYCGRDRAFT_75846
PPL: 
POSPLDRAFT_56190 POSPLDRAFT_88376 POSPLDRAFT_89125 POSPLDRAFT_89318 POSPLDRAFT_89706
LBC: 
LACBIDRAFT_185466 LACBIDRAFT_191088
MPR: 
MPER_00656 MPER_02627 MPER_10525
CCI: 
CC1G_01435
SCM: 
SCHCODRAFT_67336 SCHCODRAFT_72109 SCHCODRAFT_76427 SCHCODRAFT_80323
UMA: 
UM06118.1
PGR: 
PGTG_15038 PGTG_16628 PGTG_16629
MBR: 
MONBRDRAFT_37973
NGR: 
NAEGRDRAFT_57131 NAEGRDRAFT_58872(AM24) NAEGRDRAFT_78259
DDI: 
DDB_G0269914(tpp1)
DPP: 
DICPUDRAFT_148281
PIF: 
PITG_03813 PITG_13421
 » show all
Taxonomy
Reference
1  [PMID:10349869]
  Authors
Ezaki J, Tanida I, Kanehagi N, Kominami E.
  Title
A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase.
  Journal
J. Neurochem. 72 (1999) 2573-82.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:9989235]
  Authors
Rawlings ND, Barrett AJ.
  Title
Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis.
  Journal
Biochim. Biophys. Acta. 1429 (1999) 496-500.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
Reference
3  [PMID:10679303]
  Authors
Ezaki J, Takeda-Ezaki M, Oda K, Kominami E.
  Title
Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis.
  Journal
Biochem. Biophys. Res. Commun. 268 (2000) 904-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:10617131]
  Authors
Junaid MA, Wu G, Pullarkat RK.
  Title
Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis.
  Journal
J. Neurochem. 74 (2000) 287-94.
  Organism
Bos taurus [GN:bta]
Reference
5  [PMID:11054422]
  Authors
Lin L, Sohar I, Lackland H, Lobel P.
  Title
The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH.
  Journal
J. Biol. Chem. 276 (2001) 2249-55.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
151662-36-1
DBGET integrated database retrieval system