| Entry |
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| Name |
peptidyl-dipeptidase B;
dipeptidyl carboxyhydrolase;
atriopeptin convertase;
atrial di-(tri)peptidyl carboxyhydrolase;
peptidyldipeptidase B;
atrial dipeptidyl carboxyhydrolase;
atrial peptide convertase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Peptidyl-dipeptidases
 |
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| Reaction(IUBMB) |
Release of a C-terminal dipeptide or exceptionally a tripeptide
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| Comment |
A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl- dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II
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| Reference |
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| Authors |
Harris RB, Wilson IB. |
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| Title |
Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization. |
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| Journal |
Arch. Biochem. Biophys. 233 (1984) 667-75. |
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| Organism |
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| Reference |
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| Authors |
Harris RB, Wilson IB. |
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| Title |
Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase. |
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| Journal |
Peptides. 6 (1985) 393-6. |
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| Organism |
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| Reference |
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| Authors |
Soler DF, Harris RB. |
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| Title |
Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position. |
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| Journal |
Int. J. Pept. Protein. Res. 32 (1988) 35-40. |
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| Organism |
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| Reference |
|
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| Authors |
Soler DF, Harris RB. |
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| Title |
Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity. |
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| Journal |
Peptides. 10 (1989) 63-8. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 147014-93-5 |
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