| Entry |
|
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| Name |
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
|
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
 |
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| Reaction(IUBMB) |
Release of a C-terminal amino acid with broad specificity
|
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| Comment |
A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
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| Orthology |
| cathepsin A (carboxypeptidase C) |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | CEL: | | CBR: | | BMY: | | SMM: | | TAD: | | OTA: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | PPL: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | MGL: | | PGR: | | MBR: | | DDI: | | TET: | | PTM: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | PTI: | | TPS: | | PIF: | | LLO: | |
» show all
 |
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| Reference |
1 |
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| Authors |
Breddam, K. |
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| Title |
Serine carboxypeptidases. A review. |
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| Journal |
Carlsberg Res. Commun. 51 (1986) 83-128. |
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| Reference |
|
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| Authors |
Valls LA, Hunter CP, Rothman JH, Stevens TH. |
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| Title |
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide. |
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| Journal |
Cell. 48 (1987) 887-97. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Reference |
|
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| Authors |
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG. |
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| Title |
Inactivation of endothelin I by deamidase (lysosomal protective protein). |
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| Journal |
J. Biol. Chem. 267 (1992) 2872-5. |
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| Organism |
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| Reference |
|
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| Authors |
Miller JJ, Changaris DG, Levy RS. |
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| Title |
Purification, subunit structure and inhibitor profile of cathepsin A. |
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| Journal |
J. Chromatogr. 627 (1992) 153-62. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9046-67-7 |
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