KEGG   ENZYME: 3.4.17.12Help
Entry
EC 3.4.17.12                Enzyme                                 

Name
carboxypeptidase M;
CPM
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of C-terminal arginine or lysine residues from polypeptides
Comment
A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family)
History
EC 3.4.17.12 created 1992
Orthology
K01296  
carboxypeptidase M
Genes
HSA: 
1368(CPM)
PTR: 
452067(CPM)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
718315(CPM)
MCF: 
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
70574(Cpm)
RNO: 
314855(Cpm)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
513281(CPM)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
417843(CPM)
MGP: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XTR: 
496721(cpm)
DRE: 
550253(cpm)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
SKO: 
TCA: 
DPX: 
ISC: 
 » show all
Taxonomy
Reference
1  [PMID:3074547]
  Authors
Skidgel RA.
  Title
Basic carboxypeptidases: regulators of peptide hormone activity.
  Journal
Trends. Pharmacol. Sci. 9 (1988) 299-304.
Reference
2  [PMID:2775217]
  Authors
Deddish PA, Skidgel RA, Erdos EG.
  Title
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).
  Journal
Biochem. J. 261 (1989) 289-91.
Reference
3  [PMID:2914904]
  Authors
Skidgel RA, Davis RM, Tan F.
  Title
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones.
  Journal
J. Biol. Chem. 264 (1989) 2236-41.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
120038-28-0

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