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Entry
EC 3.4.17.23                Enzyme                                 

Name
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]
Reaction(KEGG)
Substrate
angiotensin II [CPD:C02135];
H2O [CPD:C00001]
Product
angiotensin-(1--7);
L-phenylalanine [CPD:C00079]
Comment
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
History
EC 3.4.17.23 created 2009
Orthology
K09708  angiotensin-converting enzyme 2
Genes
HSA: 59272(ACE2)
PTR: 465511(ACE2)
PPS: 100970340(ACE2)
GGO: 101142534(ACE2)
PON: 100171441(ACE2)
NLE: 100602708(ACE2)
MCC: 712790(ACE2)
MCF: 102130864(ACE2)
CSAB: 103231639(ACE2)
RRO: 104664530(ACE2)
RBB: 108539696(ACE2)
CJC: 100408882(ACE2)
SBQ: 101045190(ACE2)
MMU: 70008(Ace2)
RNO: 302668(Ace2)
CGE: 100772552(Ace2)
NGI: 103740288(Ace2)
HGL: 101697829(Ace2)
CCAN: 109702751
OCU: 100327258(ACE2)
TUP: 102484728(ACE2)
CFA: 480847(ACE2)
AML: 100465802(ACE2)
UMR: 103668146(ACE2)
ORO: 101373514(ACE2)
FCA: 554349(ACE2)
PTG: 102965716(ACE2)
AJU: 106974224(ACE2)
BTA: 509235(ACE2)
BOM: 102274886(ACE2)
BIU: 109555348(ACE2)
PHD: 102323187(ACE2)
CHX: 102184608(ACE2)
OAS: 101103622(ACE2)
SSC: 100144303(ACE2)
CFR: 102523304(ACE2)
CDK: 105100402(ACE2)
BACU: 103009000(ACE2)
LVE: 103086585(ACE2)
OOR: 101283738(ACE2)
ECB: 100055952(ACE2)
EPZ: 103568003(ACE2)
EAI: 106841569(ACE2)
MYB: 102259026(ACE2)
MYD: 102763166(ACE2)
HAI: 109395939(ACE2)
RSS: 109455043(ACE2)
PALE: 102888407(ACE2)
LAV: 100663153(ACE2)
TMU: 101343545
MDO: 100031783(ACE2)
SHR: 100917420(ACE2)
OAA: 100085223(ACE2)
GGA: 418623(ACE2)
MGP: 100541186(ACE2)
CJO: 107325566(ACE2)
APLA: 101792697(ACE2)
ACYG: 106037784(ACE2)
TGU: 100232752(ACE2)
GFR: 102037445(ACE2)
FAB: 101814772(ACE2)
PHI: 102108306(ACE2)
PMAJ: 107206020(ACE2)
CCW: 104686166(ACE2)
FPG: 101911905(ACE2)
FCH: 102045810(ACE2)
CLV: 102095592(ACE2)
EGZ: 104127303(ACE2)
AAM: 106490772(ACE2)
ASN: 102388701(ACE2)
AMJ: 102570994(ACE2)
PSS: 102452742(ACE2)
CMY: 102938941(ACE2)
CPIC: 101950848(ACE2)
ACS: 100565298(ace2)
PVT: 110075460(ACE2)
PBI: 103068164(ACE2)
GJA: 107115822(ACE2)
XLA: 100037182(ace2.S) 108707435
XTR: 100486137(ace2)
NPR: 108792313(ACE2)
DRE: 492331(ace2)
SANH: 107691301(ace2) 107695051
IPU: 108259124(ace2)
AMEX: 103030208(ace2)
TRU: 101066589(ace2)
LCO: 104919764(ace2)
NCC: 104963551(ace2)
MZE: 101480744(ace2)
XMA: 102218691(ace2)
PRET: 103462028(ace2)
NFU: 107381688(ace2)
CSEM: 103378664(ace2)
LCF: 108887946(ace2)
HCQ: 109526010(ace2)
BPEC: 110161222(ace2)
ELS: 105019921(ace2)
SFM: 108920456(ace2)
LCM: 102362771(ACE2)
CMK: 103177482(ace2)
SPU: 577312
 » show all
Taxonomy
Reference
1  [PMID:11815627]
  Authors
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P
  Title
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related  carboxypeptidase.
  Journal
J. Biol. Chem. 277 (2002) 14838-43.
  Sequence
[hsa:59272]
Reference
2  [PMID:17897633]
  Authors
Lambert DW, Hooper NM, Turner AJ
  Title
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
  Journal
Biochem. Pharmacol. 75 (2008) 781-6.
Reference
3  [PMID:14754895]
  Authors
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW
  Title
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
  Journal
J. Biol. Chem. 279 (2004) 17996-8007.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.23
IUBMB Enzyme Nomenclature: 3.4.17.23
ExPASy - ENZYME nomenclature database: 3.4.17.23
BRENDA, the Enzyme Database: 3.4.17.23

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