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Entry
EC 3.4.17.23                Enzyme                                 

Name
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]
Reaction(KEGG)
Substrate
angiotensin II [CPD:C02135];
H2O [CPD:C00001]
Product
angiotensin-(1--7);
L-phenylalanine [CPD:C00079]
Comment
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
History
EC 3.4.17.23 created 2009
Orthology
K09708  
angiotensin-converting enzyme 2
Genes
HSA: 
59272(ACE2)
PTR: 
465511(ACE2)
PPS: 
100970340(ACE2)
GGO: 
101142534(ACE2)
PON: 
100171441(ACE2)
MCC: 
712790(ACE2)
MCF: 
102130864(ACE2)
MMU: 
70008(Ace2)
RNO: 
302668(Ace2)
CGE: 
100772552(Ace2)
HGL: 
101697829(Ace2)
TUP: 
102484728(ACE2)
CFA: 
480847(ACE2)
AML: 
FCA: 
554349(ACE2)
PTG: 
102965716(ACE2)
BTA: 
509235(ACE2)
BOM: 
102274886(ACE2)
PHD: 
102323187(ACE2)
CHX: 
102184608(ACE2)
OAS: 
101103622(ACE2)
SSC: 
100144303(ACE2)
CFR: 
102523304(ACE2)
BACU: 
103009000(ACE2)
LVE: 
103086585(ACE2)
ECB: 
100055952(ACE2)
MYB: 
102259026(ACE2)
MYD: 
102763166(ACE2)
PALE: 
102888407(ACE2)
MDO: 
100031783(ACE2)
SHR: 
100917420(ACE2)
OAA: 
100085223(ACE2)
GGA: 
418623(ACE2)
TGU: 
100232752(ACE2)
FAB: 
101814772(ACE2)
PHI: 
102108306(ACE2)
APLA: 
101792697(ACE2)
FPG: 
101911905(ACE2)
FCH: 
102045810(ACE2)
CLV: 
102095592(ACE2)
ASN: 
102388701(ACE2)
AMJ: 
102570994(ACE2)
PSS: 
102452742(ACE2)
CMY: 
102938941(ACE2)
ACS: 
PBI: 
103068164(ACE2)
XTR: 
100486137(ace2)
DRE: 
492331(ace2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362771(ACE2)
CMK: 
103177482(ace2)
SPU: 
 » show all
Taxonomy
Reference
1  [PMID:11815627]
  Authors
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P
  Title
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related  carboxypeptidase.
  Journal
J. Biol. Chem. 277 (2002) 14838-43.
  Organism
Homo sapiens
  Sequence
[hsa:59272]
Reference
2  [PMID:17897633]
  Authors
Lambert DW, Hooper NM, Turner AJ
  Title
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
  Journal
Biochem. Pharmacol. 75 (2008) 781-6.
Reference
3  [PMID:14754895]
  Authors
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW
  Title
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
  Journal
J. Biol. Chem. 279 (2004) 17996-8007.
  Organism
Homo sapiens
  Sequence
[hsa:59272]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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