KEGG   ENZYME: 3.4.19.14Help
Entry
EC 3.4.19.14                Enzyme                                 

Name
leukotriene-C4 hydrolase;
gamma-glutamyl leukotrienase;
GGT5
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
leukotriene C4 + H2O = leukotriene D4 + L-glutamate [RN:R09875]
Reaction(KEGG)
Substrate
leukotriene C4 [CPD:C02166];
H2O [CPD:C00001]
Product
leukotriene D4 [CPD:C05951];
L-glutamate [CPD:C00025]
Comment
The mouse enzyme is specific for leukotriene C4, while the human enzyme also has considerable activity towards glutathione and oxidized glutathione (cf. EC 3.4.19.13, glutathione hydrolase) [3-4].
History
EC 3.4.19.14 created 2012
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K18592  
gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase
Genes
HSA: 
2678(GGT1) 2687(GGT5)
PTR: 
458711(GGT5) 470168(GGT1)
PPS: 
100967282(GGT5)
GGO: 
PON: 
NLE: 
MCC: 
MCF: 
CJC: 
100386116(GGT1) 100386469(GGT5)
MMU: 
14598(Ggt1) 23887(Ggt5)
RNO: 
116568(Ggt1) 29566(Ggt5)
CGE: 
100763802(Ggt1) 100764088(Ggt5)
HGL: 
TUP: 
102484803(GGT5) 102485218(GGT1)
CFA: 
486400(GGT1) 486401(GGT5)
AML: 
UMR: 
103669205(GGT1) 103669206(GGT5)
FCA: 
101081761(GGT1) 101082015(GGT5)
PTG: 
102958863(GGT1) 102959431(GGT5)
BTA: 
615582(GGT1) 787326(GGT5)
BOM: 
102274785(GGT5) 102275636(GGT1)
PHD: 
102334457(GGT5)
CHX: 
102182719(GGT5) 102182996(GGT1)
OAS: 
101112423(GGT5)
SSC: 
100157523(GGT5) 397095(GGT1)
CFR: 
102519279(GGT5) 102519525(GGT1)
BACU: 
102998230(GGT5) 103005716(GGT1)
LVE: 
103074197(GGT5) 103074850(GGT1)
ECB: 
100050188(GGT1) 100050259(GGT5)
MYB: 
102249132(GGT5) 102249421(GGT1)
MYD: 
PALE: 
102884483(GGT5) 102885072(GGT1)
MDO: 
SHR: 
100926551(GGT1) 100929990(GGT5)
OAA: 
GGA: 
416943(GGT5) 416945(GGT1)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
100554005(ggt1) 100555377(ggt5)
PBI: 
XLA: 
444291(ggt1-b) 734898(ggt1)
XTR: 
DRE: 
100333757 566746(ggt1l2.2) 569014(ggt1b)
TRU: 
MZE: 
OLA: 
100820714(ggt1a) 100820715(ggt1b) 100820716(ggtl1a) 100820728(ggtl1b) 101161114
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
410096(GB18219) 726158(GB20121)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_C53D5.5(C53D5.5) CELE_T03D8.6(T03D8.6)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G69820(GGT3) AT4G29210(GGT4) AT4G39640(GGT1) AT4G39650(GGT2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0001s34100g(POPTRDRAFT_174370) POPTR_0005s08450g(POPTRDRAFT_760175) POPTR_0018s06710g
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0151500-00(Os01g0151500) Os04t0457500-01(Os04g0457500)
OBR: 
BDI: 
SBI: 
SORBI_03g006000(SORBIDRAFT_03g006000) SORBI_06g018740(SORBIDRAFT_06g018740)
ZMA: 
SITA: 
ATR: 
s00002p00123000(AMTR_s00002p00123000) s00002p00123410(AMTR_s00002p00123410) s00002p00124320(AMTR_s00002p00124320) s00002p00125660(AMTR_s00002p00125660) s00002p00125730(AMTR_s00002p00125730) s00002p00126520(AMTR_s00002p00126520) s00010p00064690(AMTR_s00010p00064690) s00010p00066490(AMTR_s00010p00066490) s00036p00231190(AMTR_s00036p00231190) s00056p00019050(AMTR_s00056p00019050) s00056p00019670(AMTR_s00056p00019670) s00056p00020280(AMTR_s00056p00020280) s00109p00152050(AMTR_s00109p00152050) s00802p00001450(AMTR_s00802p00001450) s00814p00012490(AMTR_s00814p00012490) s05215p00000460(AMTR_s05215p00000460)
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT71574(AGABI1DRAFT_71574)
ABV: 
CPUT: 
SLA: 
UMA: 
PFP: 
PGR: 
MLR: 
WSE: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
ACAN: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:9139674]
  Authors
Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW
  Title
Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice.
  Journal
J. Biol. Chem. 272 (1997) 12305-10.
Reference
2  [PMID:11463821]
  Authors
Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW
  Title
Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.
  Journal
Mol. Cell. Biol. 21 (2001) 5389-95.
Reference
3  [PMID:12163373]
  Authors
Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW
  Title
Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
  Journal
Am. J. Pathol. 161 (2002) 481-90.
Reference
4  [PMID:21447318]
  Authors
Wickham S, West MB, Cook PF, Hanigan MH
  Title
Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase  enzymes.
  Journal
Anal. Biochem. 414 (2011) 208-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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