KEGG   ENZYME: 3.4.19.14Help
Entry
EC 3.4.19.14                Enzyme                                 
Name
leukotriene-C4 hydrolase;
gamma-glutamyl leukotrienase;
GGT5
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
leukotriene C4 + H2O = leukotriene D4 + L-glutamate [RN:R09875]
Reaction(KEGG)
Substrate
leukotriene C4 [CPD:C02166];
H2O [CPD:C00001]
Product
leukotriene D4 [CPD:C05951];
L-glutamate [CPD:C00025]
Comment
The mouse enzyme is specific for leukotriene C4, while the human enzyme also has considerable activity towards glutathione and oxidized glutathione (cf. EC 3.4.19.13, glutathione hydrolase) [3-4].
Reference
1  [PMID:9139674]
  Authors
Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW
  Title
Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice.
  Journal
J. Biol. Chem. 272 (1997) 12305-10.
Reference
2  [PMID:11463821]
  Authors
Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW
  Title
Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.
  Journal
Mol. Cell. Biol. 21 (2001) 5389-95.
Reference
3  [PMID:12163373]
  Authors
Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW
  Title
Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
  Journal
Am. J. Pathol. 161 (2002) 481-90.
Reference
4  [PMID:21447318]
  Authors
Wickham S, West MB, Cook PF, Hanigan MH
  Title
Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase  enzymes.
  Journal
Anal. Biochem. 414 (2011) 208-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system