KEGG   ENZYME: 3.4.19.2Help
Entry
EC 3.4.19.2                 Enzyme                                 

Name
peptidyl-glycinamidase;
carboxyamidase;
peptidyl carboxy-amidase;
peptidyl-aminoacylamidase;
carboxamidopeptidase;
peptidyl amino acid amide hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of C-terminal glycinamide from polypeptides
Comment
Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate.
History
EC 3.4.19.2 created 1978 as EC 3.4.15.2, transferred 1981 to EC 3.4.19.2
Reference
1
  Authors
Fruhaufova, L., Suska-Brezezinska, E., Barth, T. and Rychlik, I.
  Title
Rat liver enzyme inactivating oxytocin and its deamino-carba analogues.
  Journal
Coll. Czech. Chem. Commun. 38 (1973) 2793-2798.
Reference
2  [PMID:1122284]
  Authors
Nardacci NJ, Mukhopadhyay S, Campbell BJ.
  Title
Partial purification and characterization of the antidiuretic hormone-inactivating enzyme from renal plasma membranes.
  Journal
Biochim. Biophys. Acta. 377 (1975) 146-57.
Reference
3  [PMID:6766314]
  Authors
Simmons WH, Walter R.
  Title
Carboxamidopeptidase: purification and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin.
  Journal
Biochemistry. 19 (1980) 39-48.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
94047-14-0

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