| Entry |
|
|---|
| Name |
peptidyl-glycinamidase;
carboxyamidase;
peptidyl carboxy-amidase;
peptidyl-aminoacylamidase;
carboxamidopeptidase;
peptidyl amino acid amide hydrolase
|
|---|
| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
 |
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| Reaction(IUBMB) |
Cleavage of C-terminal glycinamide from polypeptides
|
|---|
| Comment |
Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate.
|
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| Reference |
1 |
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| Authors |
Fruhaufova, L., Suska-Brezezinska, E., Barth, T. and Rychlik, I. |
|---|
| Title |
Rat liver enzyme inactivating oxytocin and its deamino-carba analogues. |
|---|
| Journal |
Coll. Czech. Chem. Commun. 38 (1973) 2793-2798. |
|---|
| Reference |
|
|---|
| Authors |
Nardacci NJ, Mukhopadhyay S, Campbell BJ. |
|---|
| Title |
Partial purification and characterization of the antidiuretic hormone-inactivating enzyme from renal plasma membranes. |
|---|
| Journal |
Biochim. Biophys. Acta. 377 (1975) 146-57. |
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| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Simmons WH, Walter R. |
|---|
| Title |
Carboxamidopeptidase: purification and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin. |
|---|
| Journal |
Biochemistry. 19 (1980) 39-48. |
|---|
| Organism |
Bufo marinus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 94047-14-0 |
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