| Entry |
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| Name |
pyroglutamyl-peptidase I;
5-oxoprolyl-peptidase;
pyrase;
pyroglutamate aminopeptidase;
pyroglutamyl aminopeptidase;
L-pyroglutamyl peptide hydrolase;
pyrrolidone-carboxyl peptidase;
pyrrolidone-carboxylate peptidase;
pyrrolidonyl peptidase;
L-pyrrolidonecarboxylate peptidase;
pyroglutamidase;
pyrrolidonecarboxylyl peptidase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
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| Reaction(IUBMB) |
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
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| Comment |
A cysteine peptidase, known from bacteria, plants and animals. The enzyme from bacterial sources is used in protein sequencing, and is the type example of peptidase family C15.
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| History |
EC 3.4.19.3 created 1972 as EC 3.4.11.8, transferred 1981 to EC 3.4.19.3, modified 1997
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| Orthology |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Tsuru, D., Nakamura, K., Yoshimoto, T. and Fujiwara, K. |
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| Title |
Pyroglutamyl-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme. |
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| Journal |
Biochim. Biophys. Acta 791 (1984) 117-122. |
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| Reference |
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| Authors |
Awade AC, Cleuziat P, Gonzales T, Robert-Baudouy J. |
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| Title |
Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins. |
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| Journal |
Proteins. 20 (1994) 34-51. |
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| Reference |
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| Authors |
Patti JM, Schneider A, Garza N, Boles JO. |
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| Title |
Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus. |
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| Journal |
Gene. 166 (1995) 95-9. |
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| Sequence |
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| Reference |
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| Authors |
Le Saux O, Gonzales T, Robert-Baudouy J. |
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| Title |
Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase. |
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| Journal |
J. Bacteriol. 178 (1996) 3308-13. |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.19.3 |
| ExPASy - ENZYME nomenclature database: | 3.4.19.3 |
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