KEGG ENZYME: 3.4.19.5

ENZYME: 3.4.19.5

Entry

EC 3.4.19.5 Enzyme

Name

beta-aspartyl-peptidase;
beta-aspartyl dipeptidase;
beta-aspartyl peptidase;
beta-aspartyldipeptidase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases

Reaction(IUBMB)

Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide

Comment

Other isopeptide bonds, e.g. gamma-glutamyl and beta-alanyl, are not hydrolysed. A mammalian, cytosolic enzyme.

Orthology

K13051

beta-aspartyl-peptidase (threonine type)

Genes

HSA:	80150(ASRGL1)
PTR:	739620(ASRGL1)
PPS:	100987751(ASRGL1)
PON:	100459800
MCC:	718871(ASRGL1)
MMU:	66514(Asrgl1)
RNO:	246307(Asrgl1)
CFA:	483789(ASRGL1)
AML:	100468618
FCA:	101087268(ASRGL1)
BTA:	767970(ASRGL1)
SSC:	100517023
ECB:	100146576
MDO:	100011584
SHR:	100928751
OAA:	100089300
GGA:	421868(ASRGL1)
MGP:	100550485
TGU:	100230667
ACS:	100568030
XLA:	444536(asrgl1)
XTR:	100145284(asrgl1) 100486129
DRE:	541402(asrgl1) 570552 795494
TRU:	101067765 101073439 101074033 101076185
OLA:	101156114 101165397 101169840
BFO:	BRAFLDRAFT_59281
CIN:	100182906
SPU:	100890184 582857
DME:	Dmel_CG7860
DPO:	Dpse_GA20639
DAN:	Dana_GF21911
DER:	Dere_GG17888
DPE:	Dper_GL16551
DSI:	Dsim_GD24689
DWI:	Dwil_GK18410 Dwil_GK18649 Dwil_GK20035
DYA:	Dyak_GE17195
DGR:	Dgri_GH11081 Dgri_GH12871
DMO:	Dmoj_GI14971 Dmoj_GI17598
DVI:	Dvir_GJ17943 Dvir_GJ18932
AGA:	AgaP_AGAP011098
AAG:	AaeL_AAEL010930 AaeL_AAEL010938
CQU:	CpipJ_CPIJ003183 CpipJ_CPIJ003184
TCA:	662650 663088
API:	100158730
PHU:	Phum_PHUM334220
ISC:	IscW_ISCW000866
NVE:	NEMVE_v1g103627 NEMVE_v1g160405
HMG:	100201936(hychat-1) 100212729
AQU:	100636866
ATH:	AT3G16150 AT5G08100
ALY:	ARALYDRAFT_479069 ARALYDRAFT_908758
GMX:	100799400 100803038 100812187
MTR:	MTR_1g018760 MTR_3g102370
CSV:	101208927 101218064 101224359
RCU:	RCOM_1467530 RCOM_1589270
POP:	POPTR_740496 POPTR_746733 POPTR_754944
VVI:	100248834 100250923
OSA:	4333381
DOSA:	Os03t0597600-01(Os03g0597600) Os04t0650700-02(Os04g0650700)
BDI:	100838056 100840890 100845946
SBI:	SORBI_01g015190(SORBIDRAFT_01g015190) SORBI_06g030910(SORBIDRAFT_06g030910)
ZMA:	100283503
SMO:	SELMODRAFT_160700 SELMODRAFT_236523
PPP:	PHYPADRAFT_194001 PHYPADRAFT_55375
CME:	CMI015C
LBC:	LACBIDRAFT_299240
MPR:	MPER_03390
CCI:	CC1G_13569
SCM:	SCHCODRAFT_47760
NGR:	NAEGRDRAFT_81332
DDI:	DDB_G0279357
DPP:	DICPUDRAFT_86450
ECO:	b0828(iaaA)
ECJ:	Y75_p0801(iaaA)
ECD:	ECDH10B_0897(iaaA)
EBW:	BWG_0681(iaaA)
ECOK:	ECMDS42_0679(iaaA)
ECE:	Z1051m
EOJ:	ECO26_0955(iaaA)
EOI:	ECO111_0896(iaaA)
EOH:	ECO103_0872(iaaA)
ECG:	E2348C_0779(iaaA)
EOK:	G2583_1056(iaaA)
ELR:	ECO55CA74_05135
ECC:	c0913(ybiK)
ECP:	ECP_0841
ECI:	UTI89_C0831(ybiK)
ECV:	APECO1_1265(iaaA)
ECX:	EcHS_A0886
ECW:	EcE24377A_0899
ECM:	EcSMS35_0853 EcSMS35_1111
ECY:	ECSE_0886
ECR:	ECIAI1_0867(iaaA)
ECQ:	ECED1_0792(iaaA)
ECK:	EC55989_0873(iaaA)
ECT:	ECIAI39_0805(iaaA)
EOC:	CE10_0849(iaaA)
EUM:	ECUMN_1016(iaaA)
ECZ:	ECS88_0845(iaaA)
ELO:	EC042_0917(iaaA)
ELN:	NRG857_03715
ELH:	ETEC_0895
ESE:	ECSF_0752
ESO:	O3O_08085
ESM:	O3M_17180
ESL:	O3K_17205
ECL:	EcolC_2816
EBR:	ECB_00795(ybiK)
EBD:	ECBD_2795
EKO:	EKO11_3057
EKF:	KO11_19630(iaaA)
EAB:	ECABU_c08690(ybiK)
EDH:	EcDH1_2814
EDJ:	ECDH1ME8569_0781(iaaA)
EIH:	ECOK1_0830
ENA:	ECNA114_0770(ybiK)
ELU:	UM146_13510
EUN:	UMNK88_869
ELW:	ECW_m0886(iaaA)
ELL:	WFL_04310(iaaA)
ELC:	i14_0877(ybiK)
ELD:	i02_0877(ybiK)
ELP:	P12B_c0813(ybiK)
EBL:	ECD_00795(ybiK)
EBE:	B21_00812(iaaA)
ELF:	LF82_1081(iaaA)
ECOA:	APECO78_07810
STY:	STY0886(ybiK)
STT:	t2042(ybiK)
SEX:	STBHUCCB_21580
SENT:	TY21A_10365
STM:	STM0847(ybiK)
SEO:	STM14_990(ybiK)
SEV:	STMMW_08981
SEY:	SL1344_0823(ybiK)
SEM:	STMDT12_C09020
SEJ:	STMUK_0852(ybiK)
SEB:	STM474_0872(ybiK)
SEF:	UMN798_0920(ybiK)
SETU:	STU288_10170
SPT:	SPA1908(ybiK)
SEK:	SSPA1778
SPQ:	SPAB_02650
SEI:	SPC_0844(ybiK)
SEC:	SC0842(ybiK)
SEH:	SeHA_C0977
SHB:	SU5_01515
SEE:	SNSL254_A0915
SEW:	SeSA_A0998
SEA:	SeAg_B0888
SED:	SeD_A0948
SEG:	SG0828(ybiK)
SEL:	SPUL_2124(ybiK)
SET:	SEN0793(ybiK)
SENJ:	CFSAN001992_07205
SFL:	SF0778(ybiK)
SFX:	S0821(ybiK)
SFV:	SFV_0811(ybiK)
SFE:	SFxv_0848(iaaA)
SSN:	SSON_0810(ybiK)
SSJ:	SSON53_04450
SBO:	SBO_0718(ybiK)
SBC:	SbBS512_E2520
SDY:	SDY_0759(ybiK)
ECA:	ECA0132
PCT:	PC1_4114
PCC:	PCC21_001290
PWA:	Pecwa_4403
PEC:	W5S_4555
ETA:	ETA_21920(ybiK)
EPY:	EpC_23240(ybiK)
EPR:	EPYR_02514(ybiK)
EAM:	EAMY_1288(ybiK)
EAY:	EAM_1285
EBI:	EbC_14450
ERJ:	EJP617_23980(ybiK)
ENT:	Ent638_1322
ENC:	ECL_02891
ENO:	ECENHK_07160
ECLO:	ENC_18840
ESC:	Entcl_2988
EEC:	EcWSU1_01386(iaaA)
ENL:	A3UG_07055
EAS:	Entas_1316
EAE:	EAE_14740
EAR:	ST548_p6039
KPN:	KPN_00861(ybiK)
KPU:	KP1_1820(ybiK)
KPM:	KPHS_16950
KPP:	A79E_3379
KPE:	KPK_3705
KPO:	KPN2242_07125
KVA:	Kvar_3517
KOX:	KOX_15245
CKO:	CKO_02281
CRO:	ROD_08331(iaaA)
SPE:	Spro_1549
SRR:	SerAS9_1518
SRS:	SerAS12_1518
SRA:	SerAS13_1519
SMAF:	D781_1459
SMW:	SMWW4_v1c15330(iaaA)
PMR:	PMI1222
DDA:	Dd703_0141
DDC:	Dd586_0133
DDD:	Dda3937_03246(iaaA)
DZE:	Dd1591_3976
PAM:	PANA_1295(ybiK)
PLF:	PANA5342_2987(ybiK)
PAJ:	PAJ_0616(ybiK)
PAQ:	PAGR_g2863
PVA:	Pvag_0675(ybiK)
PAO:	Pat9b_1268
RAH:	Rahaq_1405
RAQ:	Rahaq2_1462
RAA:	Q7S_06780
PSI:	S70_08325
ROR:	RORB6_10880
EBF:	D782_2989
XCC:	XCC0229(ansA)
XCB:	XC_0239
XCV:	XCV0254
XCP:	XCR_4294
XAC:	XAC0248(ansA)
XAX:	XACM_0234
XAO:	XAC29_01275
XCI:	XCAW_00647
SML:	Smlt0887
SMT:	Smal_0741
BUJ:	BurJV3_0747
SMZ:	SMD_0766
PSU:	Psesu_0165
PSD:	DSC_05370
RHD:	R2APBS1_0886
VCH:	VC2603
VCE:	Vch1786_I2098
VCJ:	VCD_001760
VCO:	VC0395_A2181
VCR:	VC395_2716
VCM:	VCM66_2523
VCI:	O3Y_12465
VCL:	VCLMA_A2299
VVU:	VV1_1328
VVY:	VV3040
VVM:	VVMO6_00272
VPA:	VP2781
VPB:	VPBB_2637
VHA:	VIBHAR_00065
VSP:	VS_2845
VEX:	VEA_002289
VEJ:	VEJY3_14215
VFU:	vfu_A00659
VAN:	VAA_02662
SON:	SO_2115(iaaA)
SFR:	Sfri_1445
SAZ:	Sama_1617
SBL:	Sbal_1904
SBM:	Shew185_1930
SBN:	Sbal195_1937
SBP:	Sbal223_2389
SBT:	Sbal678_1976
SBS:	Sbal117_2023
SBB:	Sbal175_2449
SLO:	Shew_2171
SPC:	Sputcn32_1898
SHP:	Sput200_2093
SSE:	Ssed_2508
SPL:	Spea_2435
SHE:	Shewmr4_1837
SHM:	Shewmr7_2140
SHN:	Shewana3_1895
SHW:	Sputw3181_2110
SHL:	Shal_1845
SWD:	Swoo_2686
SWP:	swp_2782
SVO:	SVI_2456
ILO:	IL1368
CPS:	CPS_4722
PHA:	PSHAa1143(iaaA)
PSM:	PSM_A1880(iaaA)
AMC:	MADE_1008490
AMAC:	MASE_07680
AMB:	AMBAS45_08265
AMG:	AMEC673_07730
AMK:	AMBLS11_07695
AMAA:	amad1_08885
FBL:	Fbal_1441
LLO:	LLO_2535(iaaA)
NHL:	Nhal_1058
TGR:	Tgr7_0555
TKM:	TK90_1369
TNI:	TVNIR_2081(iaaA_[H])
HCH:	HCH_06718
KKO:	Kkor_1734
CVI:	CV_4047
LHK:	LHK_00847
PSE:	NH8B_2671
RSO:	RSc1378
RSC:	RCFBP_20054(iaaA)
RSL:	RPSI07_1989(iaaA)
RSN:	RSPO_c01979(iaaA)
RPI:	Rpic_1251
RPF:	Rpic12D_1317
REU:	Reut_A1928
REH:	H16_A2102(ansB)
RME:	Rmet_1406(ansB)
CTI:	RALTA_A1728(iaaA)
CNC:	CNE_1c20340(ansB3)
BMA:	BMAA0973
BMV:	BMASAVP1_0405
BML:	BMA10229_0236
BMN:	BMA10247_A1362
BPS:	BPSS1308
BPM:	BURPS1710b_A0326(ansA)
BPL:	BURPS1106A_A1771
BPD:	BURPS668_A1856
BPZ:	BP1026B_II1391
BPQ:	BPC006_II1756
BTE:	BTH_II1111
BTD:	BTI_3802(iaaA)
BVI:	Bcep1808_4718
BUR:	Bcep18194_B1869
BCN:	Bcen_4205
BCH:	Bcen2424_4161
BCM:	Bcenmc03_3355
BCJ:	BCAM1291
BAM:	Bamb_3569
BAC:	BamMC406_4050
BMU:	Bmul_4428
BMJ:	BMULJ_04081(ansA)
BCT:	GEM_4455
BXE:	Bxe_A0834
BPH:	Bphy_4227
BPY:	Bphyt_3132
BUG:	BC1001_2779
BGE:	BC1002_2373
BGF:	BC1003_2717
BYI:	BYI23_B009180
BUK:	MYA_4504
BPX:	BUPH_03318
BPE:	BP2398
BPC:	BPTD_2355
BPER:	BN118_2603
BPA:	BPP3263
BPAR:	BN117_3227
BBR:	BB3714
BBM:	BN115_3386
BBH:	BN112_4701
BPT:	Bpet1792
BAV:	BAV1157
AXY:	AXYL_01599(iaaA)
TEQ:	TEQUI_0381
TEA:	KUI_1371
TEG:	KUK_0302
TAS:	TASI_1356
TAT:	KUM_1032
AKA:	TKWG_03795
RFR:	Rfer_3101
POL:	Bpro_0141
AAV:	Aave_1656
AAA:	Acav_1686
VEI:	Veis_4589
DAC:	Daci_3603
DEL:	DelCs14_3195
VAP:	Vapar_3001
VPE:	Varpa_2625
ADN:	Alide_4414
ADK:	Alide2_4741
HSE:	Hsero_1841
CFU:	CFU_0597(ansA)
NIT:	NAL212_2859
NII:	Nit79A3_2958
NMU:	Nmul_A2166
AZA:	AZKH_p0417
CJD:	JJD26997_1791
CCO:	CCC13826_2319
CLA:	Cla_1393(ansB)
DVU:	DVU2242
DVL:	Dvul_1000
DVM:	DvMF_0839
DVG:	Deval_2088
DDE:	Dde_2284
DTO:	TOL2_C09870
ADE:	Adeh_2366
ACP:	A2cp1_1593
AFW:	Anae109_1503
ANK:	AnaeK_1498
MXA:	MXAN_1160
MFU:	LILAB_02805
MSD:	MYSTI_01208
CCX:	COCOR_01115(iaaA)
SUR:	STAUR_1777
SCL:	sce3033 sce3769
HOH:	Hoch_0724
MCI:	Mesci_6097
ATU:	Atu3044(asg)
AVI:	Avi_7322(asg)
AGR:	AGROH133_11382
RLG:	Rleg_5802
OAN:	Oant_3084
AZC:	AZC_2990
MRD:	Mrad2831_3245
MSC:	BN69_1921
CCR:	CC_0097 CC_0576
CCS:	CCNA_00096 CCNA_00612
CAK:	Caul_1122
CSE:	Cseg_0092
PZU:	PHZ_c2832
BSB:	Bresu_0540 Bresu_0706
AEX:	Astex_0920 Astex_3303
OAR:	OA238_c34300(iaaA)
MMR:	Mmar10_1162
HNE:	HNE_1675 HNE_3324
HBA:	Hbal_1330 Hbal_2313
SAL:	Sala_2824
SWI:	Swit_2127
SPHM:	G432_08315
SCH:	Sphch_3427
SSY:	SLG_25580
ELI:	ELI_10330
ACR:	Acry_1716
AMV:	ACMV_17610(iaaA)
GDI:	GDI_3138
GDJ:	Gdia_3233
RCE:	RC1_1422(aspG)
AZL:	AZL_a08250(ansB)
ALI:	AZOLI_p20293(iaaA)
PTH:	PTH_1687
KSE:	Ksed_01470
SKE:	Sked_13940
PAC:	PPA2114
PAK:	HMPREF0675_5169
PAV:	TIA2EST22_10290 TIA2EST22_10295
PAX:	TIA2EST36_10270 TIA2EST36_10275
PAZ:	TIA2EST2_10230 TIA2EST2_10235
PAD:	TIIST44_03280
PCN:	TIB1ST10_10735
PACC:	PAC1_10730 PAC1_10735
PRA:	PALO_00530
MMAR:	MODMU_4021(iaaA)
BLO:	BL1142
BLJ:	BLD_0900
BLF:	BLIF_0487
BLL:	BLJ_0545
BLB:	BBMN68_904
BLM:	BLLJ_0470
BLK:	BLNIAS_02082
BLG:	BIL_13740
BAD:	BAD_1173
BBI:	BBIF_1156
BBP:	BBPR_1204
BBF:	BBB_1139(iaaA)
AFO:	Afer_1070
ABA:	Acid345_0550
ACA:	ACP_1906
ACM:	AciX9_3717
GMA:	AciX8_0036
CTM:	Cabther_B0438
BVU:	BVU_0189
PDI:	BDI_1755
SRU:	SRU_2761(asg)
SRM:	SRM_01487(ansA) SRM_02972
RMR:	Rmar_1612
RMG:	Rhom172_1191
CPI:	Cpin_1576
NKO:	Niako_3196
PSN:	Pedsa_1170
SHG:	Sph21_0527
SCN:	Solca_3257
EVI:	Echvi_0716
DFE:	Dfer_0246 Dfer_0516
SLI:	Slin_4155
LBY:	Lbys_1513
RSI:	Runsl_4261
FAE:	FAES_1629
MTT:	Ftrac_1373 Ftrac_1567
GFO:	GFO_0747(ybiK) GFO_3399
ZPR:	ZPR_0296
CAT:	CA2559_03725
KDI:	Krodi_1280
LAN:	Lacal_0910
ASL:	Aeqsu_0962 Aeqsu_1097
PTQ:	P700755_001535
NDO:	DDD_1523 DDD_3458(ybiK)
POM:	MED152_08310(ansA)
FBA:	FIC_01466
OHO:	Oweho_1418
OTE:	Oter_4294
RBA:	RB7985(ansA)
PLM:	Plim_1012
PBS:	Plabr_2964
CYC:	PCC7424_5681
CYN:	Cyan7425_4448
AMR:	AM1_1092
GLP:	Glo7428_2957
CMP:	Cha6605_4518
NPU:	Npun_F0225
ONI:	Osc7112_5735
IAL:	IALB_2632
RRS:	RoseRS_0104
RCA:	Rcas_0343 Rcas_4430
CAU:	Caur_3511
CAG:	Cagg_0874
CHL:	Chy400_3787
HAU:	Haur_2511 Haur_2882
TRO:	trd_A0521
STI:	Sthe_2484
CAP:	CLDAP_39180
DDR:	Deide_2p01270
DMR:	Deima_1716
DPD:	Deipe_1282
TRA:	Trad_0502
OPR:	Ocepr_1219
MPG:	Theba_1845 Theba_2259
NDE:	NIDE4324(iaaA)
LFC:	LFE_1146
LFI:	LFML04_1309
CEX:	CSE_05930
TTR:	Tter_0353
MOX:	DAMO_2128(asrgl)
HSL:	OE3633R(aga)
HHI:	HAH_0648(ans)
HWC:	Hqrw_3554(asnA)
HLA:	Hlac_2332
HUT:	Huta_0415
HMU:	Hmuk_1507
NMG:	Nmag_2941
HVO:	HVO_2589
HME:	HFX_2614
HJE:	HacjB3_06535
HBO:	Hbor_09920
HXA:	Halxa_1849
NGE:	Natgr_1117
HRU:	Halru_0941
NOU:	Natoc_0385
PHO:	PH0232
PAB:	PAB0145(asnA-2)
PFU:	PF0142
PFI:	PFC_07490
PYN:	PNA2_0744
PYA:	PYCH_16850
PYS:	Py04_0296
TKO:	TK2246
TON:	TON_1392
TGA:	TGAM_1414(asnA)
TSI:	TSIB_0276
TBA:	TERMP_00945
THE:	GQS_08620
THA:	TAM4_1476
THM:	CL1_1333
ABI:	Aboo_0974
ACF:	AciM339_1132
SMR:	Smar_1517
SHC:	Shell_0927
DKA:	DKAM_0544
DMU:	Desmu_0593
DFD:	Desfe_0580
TAG:	Tagg_0484
IAG:	Igag_0237
THG:	TCELL_0913
HBU:	Hbut_0399
PFM:	Pyrfu_1579
SSO:	SSO2350(ansA-like)
SOL:	Ssol_0162
STO:	ST1827
SAI:	Saci_0402
SACN:	SacN8_01980
SACR:	SacRon12I_01975
SIS:	LS215_0178
SIA:	M1425_0147
SIM:	M1627_0147
SID:	M164_0166
SIY:	YG5714_0151
SIN:	YN1551_2750
SII:	LD85_0151
SIH:	SiH_0151
SIR:	SiRe_0147
SIC:	SiL_0138
MSE:	Msed_0685
MCN:	Mcup_1403
AHO:	Ahos_2150
PAI:	PAE3083
PIS:	Pisl_0908
PCL:	Pcal_0970
PAS:	Pars_1892
PYR:	P186_0491
POG:	Pogu_0233
TNE:	Tneu_1423
CMA:	Cmaq_1774
TUZ:	TUZN_1973
TTN:	TTX_1564(ybiK)
VDI:	Vdis_1752
VMO:	VMUT_0199
TPE:	Tpen_0841
ASC:	ASAC_0803
CLG:	Calag_0349
FFO:	FFONT_1266
CSY:	CENSYa_0248 CENSYa_1419
NGA:	Ngar_c32850
KCR:	Kcr_0879
HAH:	Halar_2873

» show all

Reference

Authors

Haley, E.E.

Title

beta-Aspartyl peptidase from rat liver.

Journal

Methods Enzymol. 19 (1970) 737-741.

Other DBs

ExplorEnz - The Enzyme Database:

3.4.19.5

IUBMB Enzyme Nomenclature:

3.4.19.5

ExPASy - ENZYME nomenclature database:

3.4.19.5

BRENDA, the Enzyme Database:

3.4.19.5

CAS:

37288-74-7

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Ontology (2)   
   KEGG BRITE (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2769)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (659)   
   KEGG DGENES (27)   
   KEGG EGENES (413)   
   KEGG MGENES (1669)   
Protein sequence (2326)   
   UniProt (1212)   
   PRF (4)   
   RefSeq(pep) (1102)   
   PDBSTR (8)   
DNA sequence (1399)   
   RefSeq(nuc) (1098)   
   GenBank (151)   
   EMBL (150)   
3D Structure (3)   
   PDB (3)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (6504)   

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