KEGG   ENZYME: 3.4.19.6Help
Entry
EC 3.4.19.6                 Enzyme                                 
Name
pyroglutamyl-peptidase II;
thyroliberinase;
pyroglutamyl aminopeptidase II;
, thyrotropin-releasing factor pyroglutamate aminopeptidase;
pyroglutamate aminopeptidase II;
pyroglutamyl peptidase II;
thyroliberin-hydrolyzing pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase;
thyrotropin-releasing hormone-degrading peptidase;
TRH aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of the N-terminal pyroglutamyl group from pGlu!His-Xaa tripeptides and pGlu!His-Xaa-Gly tetrapeptides
Comment
Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family)
Orthology
K01306  
pyroglutamyl-peptidase II
Genes
HSA: 
29953(TRHDE)
PTR: 
467071(TRHDE)
PPS: 
100977009(TRHDE)
GGO: 
101146939(TRHDE)
PON: 
100460431(TRHDE)
MCC: 
717653(TRHDE)
MMU: 
237553(Trhde)
RNO: 
366894(Trhde)
CFA: 
481166(TRHDE)
AML: 
FCA: 
101085556(TRHDE)
BTA: 
100336818(TRHDE)
SSC: 
100620702(TRHDE)
ECB: 
100057250(TRHDE)
MDO: 
100016797
OAA: 
100079276(TRHDE)
GGA: 
427868(TRHDE)
MGP: 
100550266(TRHDE)
TGU: 
100230387(TRHDE)
ACS: 
100551808
XTR: 
100489066
DRE: 
562409
TRU: 
101065693
OLA: 
101170139
 » show all
Taxonomy
Reference
1  [PMID:115687]
  Authors
Bauer K, Nowak P.
  Title
Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.
  Journal
Eur. J. Biochem. 99 (1979) 239-46.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:2862039]
  Authors
O'Connor B, O'Cuinn G.
  Title
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain.
  Journal
Eur. J. Biochem. 150 (1985) 47-52.
  Organism
Cavia porcellus
Reference
3
  Authors
Wilk, S. and Wilk, E.K.
  Title
Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme.
  Journal
Neurochem. Int. 15 (1989) 81-89.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
60063-88-9
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