KEGG   ENZYME: 3.4.21.10Help
Entry
EC 3.4.21.10                Enzyme                                 
Name
acrosin;
acrosomal proteinase;
acrozonase;
alpha-acrosin;
beta-acrosin;
upsilon-acrosin;
acrosomal protease;
acrosin amidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!
Comment
Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family)
Orthology
K01317  
acrosin
Genes
HSA: 
49(ACR)
PTR: 
458950(ACR)
PPS: 
GGO: 
PON: 
MCC: 
716579(ACR)
MMU: 
11434(Acr)
RNO: 
24163(Acr)
CFA: 
606765(ACR)
AML: 
FCA: 
101083949(ACR)
BTA: 
280711(ACR)
SSC: 
397098(ACR)
ECB: 
100057028
SHR: 
100916052
GGA: 
426864(ACR)
MGP: 
692129(ACR)
TGU: 
100226600 100229676 100230182
ACS: 
100558182
XTR: 
100495399
AVA: 
Ava_1781 Ava_4160
 » show all
Taxonomy
Reference
1  [PMID:7043204]
  Authors
Muller-Esterl W, Fritz H.
  Title
Sperm Acrosin.
  Journal
Methods. Enzymol. 80 Pt C (1981) 621-32.
Reference
2  [PMID:2500154]
  Authors
Skoog MT, Mehdi S, Wiseman JS, Bey P.
  Title
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.
  Journal
Biochim. Biophys. Acta. 996 (1989) 89-94.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:2114285]
  Authors
Keime S, Adham IM, Engel W.
  Title
Nucleotide sequence and exon-intron organization of the human proacrosin gene.
  Journal
Eur. J. Biochem. 190 (1990) 195-200.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-57-9
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