KEGG   ENZYME: 3.4.21.10Help
Entry
EC 3.4.21.10                Enzyme                                 

Name
acrosin;
acrosomal proteinase;
acrozonase;
alpha-acrosin;
beta-acrosin;
upsilon-acrosin;
acrosomal protease;
acrosin amidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!
Comment
Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family)
History
EC 3.4.21.10 created 1972
Orthology
K01317  
acrosin
Genes
HSA: 
49(ACR)
PTR: 
458950(ACR)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
716579(ACR)
MCF: 
RRO: 
CJC: 
MMU: 
11434(Acr)
RNO: 
24163(Acr)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
606765(ACR)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
280711(ACR)
BOM: 
PHD: 
CHX: 
OAS: 
443195(ACR)
SSC: 
397098(ACR)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
GGA: 
MGP: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
102938123(Acrosin) 102938344(Acrosin)
PBI: 
GJA: 
XTR: 
LCM: 
CMK: 
EHX: 
AVA: 
 » show all
Taxonomy
Reference
1  [PMID:7043204]
  Authors
Muller-Esterl W, Fritz H.
  Title
Sperm Acrosin.
  Journal
Methods. Enzymol. 80 Pt C (1981) 621-32.
Reference
2  [PMID:2500154]
  Authors
Skoog MT, Mehdi S, Wiseman JS, Bey P.
  Title
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates.
  Journal
Biochim. Biophys. Acta. 996 (1989) 89-94.
Reference
3  [PMID:2114285]
  Authors
Keime S, Adham IM, Engel W.
  Title
Nucleotide sequence and exon-intron organization of the human proacrosin gene.
  Journal
Eur. J. Biochem. 190 (1990) 195-200.
  Sequence
[hsa:49]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9068-57-9

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