KEGG   ENZYME: 3.4.21.109Help
Entry
EC 3.4.21.109               Enzyme                                 

Name
matriptase;
serine protease 14;
membrane-type serine protease 1;
MT-SP1;
prostamin;
serine protease TADG-15;
tumor-associated differentially-expressed gene 15 protein;
ST14;
breast cancer 80 kDa protease;
epithin;
serine endopeptidase SNC19
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
Comment
This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis [1,2]. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but It does not activate plasminogen, which shares high homology with HGF [1]. The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade [1,2]. Belongs in peptidase family S1A.
History
EC 3.4.21.109 created 2006
Orthology
K08670  
suppressor of tumorigenicity protein 14
Genes
HSA: 
6768(ST14)
PTR: 
100188950(ST14)
PPS: 
100969412(ST14)
GGO: 
101128044(ST14)
PON: 
100448596(ST14)
NLE: 
100583520(ST14)
MCC: 
718848(ST14)
MCF: 
102117178(ST14)
RRO: 
104656766(ST14)
CJC: 
100411816(ST14)
MMU: 
19143(St14)
RNO: 
114093(St14)
CGE: 
100755225(St14)
NGI: 
103749253(St14)
HGL: 
101697952(St14)
OCU: 
100101609(ST14)
TUP: 
102486454(ST14)
CFA: 
489278(ST14)
AML: 
100466959(ST14)
UMR: 
103660745(ST14)
FCA: 
101095767(ST14)
PTG: 
102953519(ST14)
BTA: 
767617(ST14)
BOM: 
102277353(ST14)
PHD: 
102328545(ST14)
CHX: 
102187300(ST14)
OAS: 
101119684(ST14)
SSC: 
100517843(ST14)
CFR: 
102503998(ST14)
BACU: 
102997802(ST14)
LVE: 
103071841(ST14)
ECB: 
100072676(ST14)
MYB: 
102241616(ST14)
MYD: 
102771965(ST14)
PALE: 
102887302(ST14)
MDO: 
100021603(ST14)
SHR: 
100930600(ST14)
OAA: 
100075025(ST14)
GGA: 
419731(ST14)
MGP: 
100547194(ST14)
CJO: 
107324168(ST14)
APLA: 
101797476(ST14)
TGU: 
100223474(ST14)
GFR: 
102045487(ST14)
FAB: 
101807159(ST14)
PHI: 
102099462(ST14)
CCW: 
104692158(ST14)
FPG: 
101919145(ST14)
FCH: 
102052997(ST14)
CLV: 
102084734(ST14)
AAM: 
106491009(ST14)
ASN: 
102369849(ST14)
AMJ: 
102566264(ST14)
PSS: 
102451977(ST14)
CMY: 
102929499(ST14)
ACS: 
100559139(st14)
PBI: 
103048713(ST14)
GJA: 
XLA: 
394363(st14-a)
XTR: 
448647(st14)
DRE: 
678603(st14a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
SKO: 
 » show all
Taxonomy
Reference
1  [PMID:10962009]
  Authors
Lee SL, Dickson RB, Lin CY.
  Title
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.
  Journal
J. Biol. Chem. 275 (2000) 36720-5.
Reference
2  [PMID:10373424]
  Authors
Lin CY, Anders J, Johnson M, Sang QA, Dickson RB.
  Title
Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.
  Journal
J. Biol. Chem. 274 (1999) 18231-6.
  Sequence
[hsa:6768]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
241475-96-7

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