KEGG   ENZYME: 3.4.21.115Help
Entry
EC 3.4.21.115               Enzyme                                 

Name
infectious pancreatic necrosis birnavirus Vp4 peptidase;
infectious pancreatic necrosis virus protease;
IPNV Vp4 protease;
IPNV Vp4 peptidase;
NS protease;
NS-associated protease;
Vp4 protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves the (Ser/Thr)-Xaa-Ala!(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions
Comment
Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish [2]. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus [2]. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp [2]. Belongs in peptidase family S50.
History
EC 3.4.21.115 created 2006
Reference
1  [PMID:2219718]
  Authors
Manning DS, Leong JC.
  Title
Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus.
  Journal
Virology. 179 (1990) 16-25.
Reference
2  [PMID:10666235]
  Authors
Petit S, Lejal N, Huet JC, Delmas B.
  Title
Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus.
  Journal
J. Virol. 74 (2000) 2057-66.
Reference
3
  Authors
Dobos, P.
  Title
The molecular biology of infectious pancreatic necrosis virus (IPNV).
  Journal
Annu. Rev. Fish Dis. 5 (1995) 25-54.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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