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infectious pancreatic necrosis birnavirus Vp4 peptidase;
infectious pancreatic necrosis virus protease;
IPNV Vp4 protease;
IPNV Vp4 peptidase;
NS protease;
NS-associated protease;
Vp4 protease
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Cleaves the (Ser/Thr)-Xaa-Ala!(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions
Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish [2]. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus [2]. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp [2]. Belongs in peptidase family S50.
EC created 2006
1  [PMID:2219718]
Manning DS, Leong JC.
Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus.
Virology. 179 (1990) 16-25.
2  [PMID:10666235]
Petit S, Lejal N, Huet JC, Delmas B.
Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus.
J. Virol. 74 (2000) 2057-66.
Dobos, P.
The molecular biology of infectious pancreatic necrosis virus (IPNV).
Annu. Rev. Fish Dis. 5 (1995) 25-54.
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